Optimal Sampling Sites and Methods for Detection of Pathogens Possibly Causing Community-Acquired Lower Respiratory Tract Infections

Loens, Katherine; Heirstraeten, Liesbet Van; Malhotra-Kumar, S.; Goossens, Herman; Ieven, Margareta

doi:10.1128/jcm.02037-08

Cited by 138 publications

(132 citation statements)

References 103 publications

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“…Depending on the organism, distinct diff erences are seen when comparing diff erent specimens by use of conventional diagnostic microbiology. 140 However, with more sensitive molecular methods, such as nucleic amplifi cation systems, the diff erences in recovery rates between the respiratory specimens might be more subtle.…”

Section: What Samples Should Be Used?mentioning

confidence: 99%

Antibiotic resistance—the need for global solutions

Laxminarayan

Dusé

Wattal

et al. 2013

The Lancet Infectious Diseases

3,580

2,602

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The causes of antibiotic resistance are complex and include human behaviour at many levels of society; the consequences aff ect everybody in the world. Similarities with climate change are evident. Many eff orts have been made to describe the many diff erent facets of antibiotic resistance and the interventions needed to meet the challenge. However, coordinated action is largely absent, especially at the political level, both nationally and internationally. Antibiotics paved the way for unprecedented medical and societal developments, and are today indispensible in all health systems. Achievements in modern medicine, such as major surgery, organ transplantation, treatment of preterm babies, and cancer chemotherapy, which we today take for granted, would not be possible without access to eff ective treatment for bacterial infections. Within just a few years, we might be faced with dire setbacks, medically, socially, and economically, unless real and unprecedented global coordinated actions are immediately taken. Here, we describe the global situation of antibiotic resistance, its major causes and consequences, and identify key areas in which action is urgently needed.

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Section: What Samples Should Be Used?mentioning

confidence: 99%

Antibiotic resistance—the need for global solutions

Laxminarayan

Dusé

Wattal

et al. 2013

The Lancet Infectious Diseases

3,580

2,602

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“…Since a good-quality sputum sample is difficult to obtain, particularly from older patients [30], pathogen screening was performed mainly on nasopharyngeal swab specimens. Another limitation is that sampling was not conducted on a more frequent (weekly) basis; thus, the time of the second rhinovirus infection cannot be precisely determined.…”

Section: Discussionmentioning

confidence: 99%

Prolonged shedding of rhinovirus and re-infection in adults with respiratory tract illness

et al. 2014

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Rhinovirus infections occur frequently throughout life and have been reported in about onethird of asymptomatic cases. The clinical significance of sequential rhinovirus infections remains unclear.To determine the incidence and clinical relevance of sequential rhinovirus detections, nasopharyngeal samples from 2485 adults with acute cough/lower respiratory illness were analysed. Patients were enrolled prospectively by general practitioners from 12 European Union countries during three consecutive years (2007)(2008)(2009)(2010). Nasopharyngeal samples were collected at the initial general practitioner consultation and 28 days thereafter and symptom scores were recorded by patients over that period.Rhinovirus RNA was detected in 444 (18%) out of 2485 visit one samples and in 110 (4.4%) out of 2485 visit two respiratory samples. 21 (5%) of the 444 patients had both samples positive for rhinovirus. Genotyping of both virus detections was successful for 17 (81%) out of 21 of these patients. Prolonged rhinovirus shedding occurred in six (35%) out of 21 and re-infection with a different rhinovirus in 11 (65%) out of 21. Rhinovirus re-infections were significantly associated with chronic obstructive pulmonary disease (p50.04) and asthma (p50.02) and appeared to be more severe than prolonged infections.Our findings indicate that in immunocompetent adults rhinovirus re-infections are more common than prolonged infections, and chronic airway comorbidities might predispose to more frequent rhinovirus re-infections. @ERSpublications Chronic airway comorbidities might predispose to more frequent rhinovirus re-infections in immunocompetent adults

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“…Чувствительность бактериологического метода исследования крови низка [15]. Так, по данным K. Loens et al (2009), бактериологическое исследова ние крови высокоспецифично, но положительный результат отмечается в небольшом числе случаев (4-18 %) [16].…”

Section: пульмонология 5'2014unclassified

“…Так, по данным K. Loens et al (2009), бактериологическое исследова ние крови высокоспецифично, но положительный результат отмечается в небольшом числе случаев (4-18 %) [16]. В работе D.Lakhani и P.Muley (2013) гемокультуры были выделены у 6,1 % детей, посту пивших в стационар по поводу тяжелой ВП [15]. В исследовании A.Mendoza Paredes et al (2013), прове денном у детей (n = 535) до 3 лет, госпитализирован ных по поводу пневмонии и полностью привитых по возрасту (в т. ч. пневмококковой и гемофильной вакцинами), процент положительных гемокультур составил 2,2 %.…”

Section: пульмонология 5'2014unclassified

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Etiologic diagnosis of communityacquired pneumonia in children

Протасова¹,

Перьянова²,

Ильенкова³

2014

Pulʹmonologiâ (Mosk.)

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ГБОУ ВПО "Красноярский государственный медицинский университет им. проф. В.Ф.Войно Ясенецкого" Минздрава России: 660022, Красноярск, ул. Партизана Железняка, 1 РезюмеПредставлен обзор современных методов этиологической диагностики внебольничной пневмонии у детей по результатам проведенных в последние годы исследований. Приведены данные о чувствительности и специфичности различных методов диагностики. Проанали зированы достоинства и недостатки традиционных методов микробиологической диагностики. Представлены возможности примене ния молекулярных методов исследования как наиболее информативных, быстрых и простых в применении. Ключевые слова: внебольничная пневмония, дети, этиология, бактериологический метод, молекулярно генетические методы. SummaryThe paper represents a systematic review of current etiological diagnostic methods in childhood community acquired pneumonia based on studies and guidelines of recent years. The authors compare sensitivity and specificity of different diagnostic methods, advantages and limitations of differ ent routine microbiological diagnostic approaches. According to most opinions molecular methods are very valuable, quick and easy to use but should be combined with culturing and other routine tests for better interpretation of results.

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Optimal Sampling Sites and Methods for Detection of Pathogens Possibly Causing Community-Acquired Lower Respiratory Tract Infections

Cited by 138 publications

References 103 publications

Antibiotic resistance—the need for global solutions

Antibiotic resistance—the need for global solutions

Prolonged shedding of rhinovirus and re-infection in adults with respiratory tract illness

Etiologic diagnosis of communityacquired pneumonia in children

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