Objective. To compare and analyze the clinical efficacy of proximal femoral nail anti-rotation (PFNA) and percutaneous compression plate (PCCP) for minimally invasive treatment of femoral intertrochanteric fractures. Methods. A retrospective analysis of 98 patients with femoral intertrochanteric fractures admitted to our hospital from January 2019 to December 2020 was used as the research object, and they were divided into PFNA group and PCCP group according to different treatment methods, with 51 cases and 47 cases. The intraoperative and postoperative indicators were compared between the two groups of patients. Results. There was no significant difference in the operative time, postoperative fracture healing time, and Harris score of hip joint function between the two groups (t = −1.43, 1.86, 1.63;
P
>
0.05
). Compared with the PFNA group, the intraoperative blood loss and postoperative drainage volume in the PCCP group were lower than those in the PFNA group (t = 11.38, 9.66;
P
<
0.05
). Compared with the PFNA group, the time of weight-bearing in the PCCP group was longer than that in the PFNA group (t = −2.23,
P
<
0.05
). The total incidence of postoperative complications was 7.84% in the PFNA group and 10.64% in the PCCP group, and there was no significant difference between the two groups (
P
>
0.05
). Conclusion. The PFNA and PCCP are both effective measures for the clinical treatment of intertrochanteric fractures, and internal fixation should be reasonably selected according to the specific conditions of the patients.