Optimal threshold in low-dose CT quantification of emphysema

Cao, Xianxian; Jin, Chenwang; Tan, Tao; Guo, Youmin

doi:10.1016/j.ejrad.2020.109094

Cited by 8 publications

(5 citation statements)

References 26 publications

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“…Notably, some Authors have suggested that thresholds higher than -950HU (e.g., −940HU, −930HU) should be preferred for quantifying emphysema at LDCT imaging [25, 26]. As such, it can be speculated that a simple adjustment of software thresholds for emphysema quantification might overcome potential limitations due to different radiation dose CT protocols.…”

Section: Discussionmentioning

confidence: 99%

Consistency of automated coronary calcium score and extent of emphysema with different CT scanners and radiation dose protocols in lung cancer screening

Ledda,

Milanese,

Balbi

et al. 2024

Preprint

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Objective. To assess the consistency of automated measurements of coronary artery calcification (CAC) burden and emphysema extent on computed tomography (CT) images acquired with different scanners and radiation dose protocols in a lung cancer screening (LCS) population. Materials and Methods. The analysis included two LCS cohorts, named inter-scanner cohort, whose subjects underwent two consecutive screening rounds with two different dual-source CT scanners, and inter-dose cohort, whose subjects underwent a low-dose CT scan and an ultra-low dose CT scan. Exclusion criteria for CAC measurements were software failure, previous history of CVD and/or of coronary stenting, whereas for emphysema assessment software failure only. CT images were retrospectively analyzed by a fully automated AI software for CAC scoring, using three predefined Agatston score categories (0-99, 100-399, and ≥ 400), and emphysema quantification, using the percentage of low attenuation areas (%LAA). Demographic and clinical data were obtained from the written questionnaire completed by each participant at the first visit. Agreement for CAC and %LAA categories was measured by the k-Cohen Index with Fleiss-Cohen weights (Kw) and 95% Confidence Interval (CI). Results. In the inter-scanner cohort, an overlap of CAC strata was observed in 218/245 (90%) volunteers with an almost perfect agreement (Kw= 0.91, 95%CI 0.88-0.95), while an overlap of %LAA strata in 182/256 (71%) volunteers, with a substantial agreement (Kw= 0.70, 95%CI 0.63-0.76). In the inter-dose cohort, an overlap of CAC strata was observed in 275/327 (84%) volunteers, with an almost perfect agreement (Kw= 0.86, 95%CI 0.82-0.90), while an overlap of %LAA strata was found in 204/356 (57%) volunteers, with a moderate agreement (Kw= 0.57, 95%CI 0.51-0.63). Conclusion. Automated CAC and emphysema quantification showed consistent results when applied on CT images acquired with different scanners and different radiation dose CT protocols in two LCS cohorts.

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Section: Discussionmentioning

confidence: 99%

Consistency of automated coronary calcium score and extent of emphysema with different CT scanners and radiation dose protocols in lung cancer screening

Ledda,

Milanese,

Balbi

et al. 2024

Preprint

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“…The Siberian Journal of Clinical and Experimental Medicine С учетом распространения программ скрининга рака легкого [47] появляется возможность денситометрического анализа низкодозной КТ (НДКТ). Однако подобный анализ сопряжен с риском девиации получаемых результатов из-за повышенного шума на изображениях [48] и может потребовать использования специфических для НДКТ пороговых значений рентгеновской плотности [49].…”

Section: сибирский журнал клинической и экспериментальной медициныunclassified

Possibilities of densitometry in the assessment of diffuse changes in the lung parenchyma

Suchilova,

Blokhin,

Kodenko

et al. 2023

SJCEM

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The data obtained from chest computed tomography (CT) can be analyzed not only visually, but also quantitatively. Quantitative assessment allows a more accurate and objective evaluation of the disease severity. Densitometry is the most researched way to quantify CT data – automatic analysis of lung densities expressed in Hounsfield units. This review is focused on the types of diseases that can be characterized by the formalization of the diagnostic task and application of densitometry, as well as on the limitations of the method and the ways to cope with them.

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“…한편 1988년에 처음 시도된 음영 마스크법(density mask method)이 점차 발전하여 최근까지도 활발히 이용되고 있는데, 이는 특정 복셀(voxel)의 하운스필드값(Hounsfield unit; 이하 HU)이 기준값 이하일 경우 폐기종에 이환된 것으로 보고 전체 폐실질에서 폐기종에 이환된 부위의 비율을 폐기종 지수로 수치화하는 방법이다( 14 ). 초기에는 그 기준값으로 −910 HU가 제시되었으나, 이후 −960 혹은 −970 HU가 제시되었으며( 15 ), 현재는 −950 HU가 가장 많이 쓰이고 있다( 16 ), 최근에는 폐암 검진에 쓰이는 저선량 CT에서 아시아인을 대상으로 할 때 −940 HU의 임상적 의미가 더 크다는 연구도 발표된 바 있다( 17 ).…”

Section: 폐기종의 시각적 분류unclassified

Pulmonary Emphysema: Visual Interpretation and Quantitative Analysis

김¹

2021

J Korean Soc Radiol

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폐기종은 만성 폐쇄성 폐질환을 유발하는 질환으로, CT는 폐기종을 정확하게 진단하는 데 가장 유용한 검사이다. 폐기종의 중증도는 시각적 분류 혹은 정량적 분석 등의 방법으로 평가할 수 있으며, 최근에는 딥러닝을 활용한 폐기종 연구도 다양하게 이루어지고 있다. 이러한 폐기종의 중증도 분류 방법은 다양한 연구에서 그 임상적 유용성을 입증받고 있으며, 한계점으로 지적되고 있는 측정의 신뢰성을 향상시키려는 노력 또한 이어지고 있다.

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Optimal threshold in low-dose CT quantification of emphysema

Cited by 8 publications

References 26 publications

Consistency of automated coronary calcium score and extent of emphysema with different CT scanners and radiation dose protocols in lung cancer screening

Consistency of automated coronary calcium score and extent of emphysema with different CT scanners and radiation dose protocols in lung cancer screening

Possibilities of densitometry in the assessment of diffuse changes in the lung parenchyma

Pulmonary Emphysema: Visual Interpretation and Quantitative Analysis

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