2023
DOI: 10.1101/2023.07.01.547049
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Optimal Transport Method-Based Gene Filter (GF) Denoising Algorithm for Enhancing Spatially Resolved Transcriptomics Data

Abstract: The recent advancements in spatially resolved transcriptomics (SRT) technology have enabled the acquisition of gene expression data at near- or sub-single-cell resolution, along with simultaneous imaging of physical locations. Nevertheless, necessary experimental procedures such as tissue fixation, permeabilization, and tissue removal inevitably induce the diffusion of transcribed molecules. Consequently, this leads to the partial capture of ex-situ transcripts in SRT data, thereby introducing a considerable a… Show more

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