Optimal vitamin D status and serum parathyroid hormone concentrations in African American women

Aloia, John F.; Talwar, Sonia A; Pollack, Simcha; Feuerman, Martin; Yeh, James K.

doi:10.1093/ajcn/84.3.602

Cited by 157 publications

(139 citation statements)

References 66 publications

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“…Further, our estimate is similar to estimates obtained in other populations and the same as the global estimate for the optimal 25-hydroxyvitamin D concentration of 450 nmol/l suggested by Lips, (2004). Aloia et al, (2006) recently conducted a systematic review that included 31 studies that reported a 25-hydroxyvitamin D threshold for PTH suppression. There was a wide range of thresholds for 25-hydroxyvitamin D of 25 to 122 nmol/l with those using the radio-immuno assay for vitamin D analysis clustered around 40-50 nmol/l.…”

Section: Vitamin D and Pth In Southeast Asian Women Tj Green Et Alsupporting

confidence: 87%

“…Poor calcium absorption owing to vitamin D insufficiency results in a compensatory rise in parathyroid hormone leading to accelerated bone loss (Aloia et al, 2006;Bischoff-Ferrari et al, 2006). Cutoffs that define vitamin D insufficiency are based primarily on the concentration of 25-hydroxyvitamin D above which there is no further suppression of parathyroid hormone (PTH), somewhere between 25 and 122 nmol/l (Aloia et al, 2006). However, these cutoffs have been based largely on studies in older Europeans and only one was carried out in women of child-bearing age (Aloia et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

“…Cutoffs that define vitamin D insufficiency are based primarily on the concentration of 25-hydroxyvitamin D above which there is no further suppression of parathyroid hormone (PTH), somewhere between 25 and 122 nmol/l (Aloia et al, 2006). However, these cutoffs have been based largely on studies in older Europeans and only one was carried out in women of child-bearing age (Aloia et al, 2006). Furthermore, in these studies the PTH suppressing effect of 25-hydroxyvitamin D has been found to differ with calcium intake (Aloia et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

“…However, these cutoffs have been based largely on studies in older Europeans and only one was carried out in women of child-bearing age (Aloia et al, 2006). Furthermore, in these studies the PTH suppressing effect of 25-hydroxyvitamin D has been found to differ with calcium intake (Aloia et al, 2006). Generally, at lower calcium intakes a higher concentration of 25-hydroxyvitamin D was required to cause maximal suppression of PTH.…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D status and its association with parathyroid hormone concentrations in women of child-bearing age living in Jakarta and Kuala Lumpur

et al. 2007

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Objective: To describe the vitamin D status of women living in two Asian cities, -Jakarta (61S) and , to examine the association between plasma 25-hydroxyvitamin D and parathyroid hormone (PTH) concentrations, and to determine a threshold for plasma 25-hydroxyvitamin D above which there is no further suppression of PTH. Also, to determine whether dietary calcium intake influences the relationship between PTH and 25-hydroxyvitamin D. Design: Cross-sectional. Setting: Jakarta, Indonesia and Kuala Lumpur, Malaysia. Participants: A convenience sample of 504 non-pregnant women 18-40 years. Main measures: Plasma 25-hydroxyvitamin D and PTH. Results: The mean 25-hydroxyvitamin D concentration was 48 nmol/l. Less than 1% of women had a 25-hydroxyvitamin D concentration indicative of vitamin D deficiency (o17.5 nmol/l); whereas, over 60% of women had a 25-hydroxyvitamin D concentration indicative of insufficiency (o50 nmol/l). We estimate that 52 nmol/l was the threshold concentration for plasma 25-hydroxyvitamin D above which no further suppression of PTH occurred. Below and above this concentration the slopes of the regression lines were À0.18 (different from 0; P ¼ 0.003) and À0.01 (P ¼ 0.775), respectively. The relation between vitamin D status and parathyroid hormone concentration did not differ between women with low, medium or high calcium intakes (P ¼ 0.611); however, even in the highest tertile of calcium intake, mean calcium intake was only 657 mg/d. Conclusion: On the basis of maximal suppression of PTH we estimate an optimal 25-hydroxyvitamin D concentration of B 50 nmol/l. Many women had a 25-hydroxyvitamin D below this concentration and may benefit from improved vitamin D status.

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Section: Vitamin D and Pth In Southeast Asian Women Tj Green Et Alsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Vitamin D status and its association with parathyroid hormone concentrations in women of child-bearing age living in Jakarta and Kuala Lumpur

et al. 2007

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“…However, this relation was generally not linear: PTH decreases until the 25VTD reaches a value threshold above which the PTH plateaus. These studies were recently listed and commented by Aloia et al (24). The reported thresholds varied coarsely between 16 and 44 ng/mL (40 and 110 nmol/L) according to the methodology used to evaluate the relation between 25VTD and PTH but also according to the studied population.…”

Section: Vitamin D Deficiency and ''Desirable'' Serum Valuesmentioning

confidence: 99%

Vitamin D: current status and perspectives

Cavalier

Chapelle

Souberbielle

2009

Clinical Chemistry and Laboratory Medicine

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The role of vitamin D in maintaining bone health has been known for decades. Recently, however, the discovery that many tissues expressed the vitamin D receptor and were able to transform the 25-OH vitamin D into its most active metabolite, 1,25-(OH) 2 vitamin D, has led to a very promising future for this ''old'' molecule. Indeed, observational studies, and more and more interventional studies, are raising the importance of a significant vitamin D supplementation for not-only skeletal benefits. Among them, 25-OH vitamin D has been found to play an important role in prevention of cancers, auto-immune diseases, cardiovascular diseases, diabetes, and infections. Vitamin D deficiency, defined as serum 25-OH vitamin D levels -30 ng/mL, is very common in our population. The cost/benefit ratio and some recently published studies are clearly now in favor of a controlled and efficient vitamin D supplementation in these patients presenting a 25-OH vitamin D level -30 ng/mL. More attention should also be focused on pregnant and lactating women, as well as children and adolescents. Clin Chem Lab Med 2009;47:120-7.

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Effect of High-Dose vs Standard-Dose Wintertime Vitamin D Supplementation on Viral Upper Respiratory Tract Infections in Young Healthy Children

Aglipay

Birken

Parkin

et al. 2017

JAMA

123

114

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for the TARGet Kids! Collaboration IMPORTANCE Epidemiological studies support a link between low 25-hydroxyvitamin D levels and a higher risk of viral upper respiratory tract infections. However, whether winter supplementation of vitamin D reduces the risk among children is unknown. OBJECTIVE To determine whether high-dose vs standard-dose vitamin D supplementation reduces the incidence of wintertime upper respiratory tract infections in young children. DESIGN, SETTING, AND PARTICIPANTS A randomized clinical trial was conducted during the winter months between September 13, 2011, and June 30, 2015, among children aged 1 through 5 years enrolled in TARGet Kids!, a multisite primary care practice-based research network in Toronto, Ontario, Canada.INTERVENTIONS Three hundred forty-nine participants were randomized to receive 2000 IU/d of vitamin D oral supplementation (high-dose group) vs 354 participants who were randomized to receive 400 IU/d (standard-dose group) for a minimum of 4 months between September and May.MAIN OUTCOME MEASURES The primary outcome was the number of laboratory-confirmed viral upper respiratory tract infections based on parent-collected nasal swabs over the winter months. Secondary outcomes included the number of influenza infections, noninfluenza infections, parent-reported upper respiratory tract illnesses, time to first upper respiratory tract infection, and serum 25-hydroxyvitamin D levels at study termination. RESULTSAmong 703 participants who were randomized (mean age, 2.7 years, 57.7% boys), 699 (99.4%) completed the trial. The mean number of laboratory-confirmed upper respiratory tract infections per child was 1.05 (95% CI, 0.91-1.19) for the high-dose group and 1.03 (95% CI, 0.90-1.16) for the standard-dose group, for a between-group difference of 0.02 (95% CI, −0.17 to 0.21) per child. There was no statistically significant difference in number of laboratory-confirmed infections between groups (incidence rate ratio [RR], 0.97; 95% CI, 0.80-1.16). There was also no significant difference in the median time to the first laboratory-confirmed infection: 3.95 months (95% CI, 3.02-5.95 months) for the high-dose group vs 3.29 months (95% CI, 2.66-4.14 months) for the standard-dose group, or number of parent-reported upper respiratory tract illnesses between groups (625 for high-dose vs 600 for standard-dose groups, incidence RR, 1.01; 95% CI, 0.88-1.16). At study termination, serum 25-hydroxyvitamin D levels were 48.7 ng/mL (95% CI, 46.9-50.5 ng/mL) in the high-dose group and 36.8 ng/mL (95% CI, 35.4-38.2 ng/mL) in the standard-dose group.CONCLUSIONS AND RELEVANCE Among healthy children aged 1 to 5 years, daily administration of 2000 IU compared with 400 IU of vitamin D supplementation did not reduce overall wintertime upper respiratory tract infections. These findings do not support the routine use of high-dose vitamin D supplementation in children for the prevention of viral upper respiratory tract infections.

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Optimal vitamin D status and serum parathyroid hormone concentrations in African American women

Abstract: Although a threshold for 25(OH)D can be identified, we suggest that it should not be used to recommend optimal vitamin D status.

Cited by 157 publications

References 66 publications

Vitamin D status and its association with parathyroid hormone concentrations in women of child-bearing age living in Jakarta and Kuala Lumpur

Vitamin D status and its association with parathyroid hormone concentrations in women of child-bearing age living in Jakarta and Kuala Lumpur

Vitamin D: current status and perspectives

Effect of High-Dose vs Standard-Dose Wintertime Vitamin D Supplementation on Viral Upper Respiratory Tract Infections in Young Healthy Children

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