Optimising Wellbeing in Patients with Diabetic Foot Ulcers

McIntosh, Caroline; Ivory, John D.; Gethin, Georgina; MacGilchrist, Claire

doi:10.35279/jewma201905.02

Cited by 8 publications

(9 citation statements)

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“…Pure cultures of individual strains were stored at −80 °C using Microbank vials (Pro-Lab, Bromborough, UK). Strains were numbered according to participant number [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] followed by sequential numbering for each successive strain obtained from that DFI (e.g. 5.1, 5.2, 5.3 representing the first three strains obtained from DFI 5).…”

Section: Obtaining Individual Strains From Polymicrobial Dfi Tissue H...mentioning

confidence: 99%

“…Diabetic foot ulcers (DFU) are a common and serious complication of diabetes with up to 25 % of diabetic individuals experiencing a DFU in their lifetime [3]. Living with DFUs can have a significant physical, social and psychological impact on individuals [4]. DFUs can limit mobility, ability to work and ultimately may become life threatening.…”

Section: Introductionmentioning

confidence: 99%

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In vitro efficacy of antibiotic loaded calcium sulfate beads (Stimulan Rapid Cure) against polymicrobial communities and individual bacterial strains derived from diabetic foot infections

Fletcher

Porter

Boulton

et al. 2022

Journal of Medical Microbiology

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Introduction. Diabetic foot infection (DFI) is the main reason for diabetes-related hospitalisation and is a major cause of diabetes-related amputation. DFIs are often complicated by ischaemia in the affected limb, the presence of polymicrobial biofilms and increasingly the occurrence of antibiotic resistant bacteria. Hypothesis/Gap statement. Antibiotic loaded beads could inhibit the growth of polymicrobial DFI communities with differing compositions in vitro. Aim. This study investigates the in vitro efficacy of antibiotic loaded calcium sulfate beads (Stimulan Rapid Cure, Biocomposites Ltd., UK) against polymicrobial DFI communities and individual bacterial strains derived from DFIs. Methodology. Debrided tissue obtained from the base of infected diabetic foot ulcers was homogenised and spread over the surface of Columbia blood agar (CBA) and fastidious anaerobe agar (FAA) plates. Calcium sulfate beads containing a combination of vancomycin and gentamicin were then placed on the surface of the agar and following incubation, zones of inhibition (ZOI) were measured. For individual bacterial strains isolated from the infected tissue, calcium sulfate beads containing vancomycin, gentamicin, flucloxacillin or rifampicin and beads containing a combination of vancomycin and gentamicin or flucloxacillin and rifampicin were tested for their ability to inhibit growth. Results. Calcium sulfate beads loaded with a combination of vancomycin and gentamicin were able to inhibit bacterial growth from all polymicrobial tissue homogenates tested, with ZOI diameters ranging from 15 to 40 mm. In the case of individual bacterial strains, beads containing combinations of vancomycin and gentamicin or flucloxacillin and rifampicin were able to produce ZOI with Gram-positive facultatitive anaerobic strains such as Staphylococcus aureus and Enterococcus faecalis , Gram-negative facultative anaerobic strains such as Pseudomonas aeruginosa and obligate anaerobic strains such as Finegoldia magna even where acquired resistance to one of the antibiotics in the combination was evidenced. Conclusion. The local use of calcium sulfate beads containing a combination of two antibiotics demonstrated high efficacy against polymicrobial DFI communities and individual DFI bacterial strains in in vitro zone of inhibition tests. These results show promise for clinical application, but further research and clinical studies are required.

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Section: Obtaining Individual Strains From Polymicrobial Dfi Tissue H...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In vitro efficacy of antibiotic loaded calcium sulfate beads (Stimulan Rapid Cure) against polymicrobial communities and individual bacterial strains derived from diabetic foot infections

Fletcher

Porter

Boulton

et al. 2022

Journal of Medical Microbiology

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“…Tabel 2 menunjukan mayoritas responden memiliki lama menderita luka ≥45 hari ada 46 responden dengan persentase 57,5%. Proses penyembuhan luka yang lambat membuat lama menderita diabetic foot ulcer memanjang berdampak gejala fisik berupa nyeri, ketidaknyamanan, isolasi sosial, dan penurunan mobilitas (13). Gejala fisik ini Tabel 1.…”

Section: Hasil Dan Pembahasanunclassified

“…Proses penyembuhan luka yang lambat membuat lama menderita diabetic foot ulcer memanjang berdampak gejala fisik berupa nyeri, ketidaknyamanan, isolasi sosial, dan penurunan mobilitas kemudian gejala fisik ini dapat menghasilkan keadaan emosional negatif, seperti kecemasan dan depresi, yang mempengaruhi citra tubuh dan harga diri seseorang, pada akhirnya mempengaruhi seluruh kesejahteraan psikologis mereka (13).…”

Section: Hasil Dan Pembahasanunclassified

Hubungan Lama Menderita Luka dengan Harga Diri Pasien Diabetic Foot Ulcer

Wulandari

Diani

Lestari

2021

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“…Specifically, it occurs in T2DM patients with leg injuries. Patients will get an impact in addition to physical and psychological health disorders, called spiritual well-being disorders (McIntosh. C., Ivory.…”

Section: Introductionmentioning

confidence: 99%

Differences In Level Of Spiritual Well-Being Of Patients With Type 2 Diabetes Mellitus In Urban And Rural Areas

Suyanto¹,

Astuti²

2022

jkg

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Background: Patients with Type 2 Diabetes Mellitus (T2DM) require a prolonged treatment time so that their condition can get worse. This incident is related chiefly to spiritual well-being disorders such as boredom and hopelessness, which results in decreased Diabetes management. The study aims to analyze differences in the spiritual well-being level of T2DM patients in urban and rural areas. Methods: Quasi-experimental method with a two-group pre-post-test design without control was employed in this study. The population in the rural area were T2DM patients in Matesih Subdistrict, and the population in the urban area were members of the Persadia Ngringo unit whose. Samples were taken using purposive sampling, obtaining 120 people. Data were collected using the SWBS questionnaire made by Ellison and modified with a validity of 0.803 and reliability of 0.911. After the pretest was carried out, the respondents were given a pocketbook and lectures on how to maintain spiritual well-being. Then, a posttest was conducted, obtaining normality of 0.93, causing the data to be analyzed using a t-test. Results: The spiritual well-being of people with T2DM in villages was 40% higher than those living in cities. The results of the t-test obtained a significant value of 0.04. Conclusion: There are differences in the spiritual well-being of T2DM patients in urban and rural areas. Attention and support to the spiritual well-being of T2DM patients should be given to carry out diabetes management properly.

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Optimising Wellbeing in Patients with Diabetic Foot Ulcers

Abstract: Living with diabetic foot ulceration can have a significant impact on a person’s physical and psychological health. All members of the multidisciplinary team have a responsibility to consider the importance of wellbeing assessment and to be mindful of a number of suggested approaches.

Cited by 8 publications

References 0 publications

In vitro efficacy of antibiotic loaded calcium sulfate beads (Stimulan Rapid Cure) against polymicrobial communities and individual bacterial strains derived from diabetic foot infections

In vitro efficacy of antibiotic loaded calcium sulfate beads (Stimulan Rapid Cure) against polymicrobial communities and individual bacterial strains derived from diabetic foot infections

Hubungan Lama Menderita Luka dengan Harga Diri Pasien Diabetic Foot Ulcer

Differences In Level Of Spiritual Well-Being Of Patients With Type 2 Diabetes Mellitus In Urban And Rural Areas

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