Optimization and analysis of microwave-assisted extraction of bioactive compounds from Mimosa pudica L. using RSM &amp; ANFIS modeling

Vinothapooshan, G.; Gurumani, Vijaya; Kunjiappan, Selvaraj; Panneerselvam, Theivendran; Somasundaram, Balasubramanian; Kannan, S.; Chowdhury, Anindita; Saravanan, Govindraju; Bhattacharjee, Chiranjib

doi:10.1007/s11694-017-9634-y

Cited by 44 publications

(17 citation statements)

References 29 publications

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“…In the literature, there are two types of mathematical models dedicated to microwave extraction: theoretical models based on chemical engineering principles about solid–liquid diffusion [ 39 , 40 , 41 , 42 ] and empirical statistical models based mostly on Response Surface Methodology (RSM) [ 17 , 31 , 43 , 44 , 45 ] but also on Adaptive Neuro-Fuzzy Inference System (ANFIS) statistical methodology [ 46 , 47 ].…”

Section: Discussionmentioning

confidence: 99%

Optimization of Vacuum-Microwave-Assisted Extraction of Natural Polyphenols and Flavonoids from Raw Solid Waste of the Orange Juice Producing Industry at Industrial Scale

et al. 2021

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Orange pomace (OP) is a solid waste produced in bulk as a byproduct of the orange juice industry and accounts for approximately 50% of the quantity of the fruits processed into juice. In numerous literature references there is information about diverse uses of orange pomace for the production of high-added-value products including production of natural antioxidant and antimicrobial extracts rich in polyphenols and flavonoids which can substitute the hazardous chemical antioxidants/antimicrobials used in agro-food and cosmetics sectors. In this work and for the first time, according to our knowledge, the eco-friendly aqueous vacuum microwave assisted extraction of orange pomace was investigated and optimized at real industrial scale in order to produce aqueous antioxidant/antimicrobial extracts. A Response Surface Optimization methodology with a multipoint historical data experimental design was employed to obtain the optimal values of the process parameters in order to achieve the maximum rates of extraction of OP total polyphenols and/or total flavonoids for economically optimum production at industrial scale. The three factors used for the optimization were: (a) microwave power (b) water to raw pomace ratio and (c) extraction time. Moreover, the effectiveness and statistical soundness of the derived cubic polynomial predictive models were verified by ANOVA.

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Section: Discussionmentioning

confidence: 99%

Optimization of Vacuum-Microwave-Assisted Extraction of Natural Polyphenols and Flavonoids from Raw Solid Waste of the Orange Juice Producing Industry at Industrial Scale

et al. 2021

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“…Vacuum-microwave-assisted extraction is a typical paradigm of a solid–liquid extraction and many researchers have developed models for the prediction of the concentration or alternatively of the amount of the extracted bioactive compounds. In general, there are two types of mathematical models dedicated to microwave extraction: theoretical models based on chemical engineering principles of solid–liquid diffusion [ 52 , 53 , 54 , 55 ] and empirical statistical models based mostly on response surface methodology (RSM) [ 56 , 57 , 58 , 59 , 60 ] but also on adaptive neuro-fuzzy inference system (ANFIS) statistical methodology [ 61 , 62 ]. From the abovementioned models, the theoretical ones are not very useful in the case we need to obtain the optimum conditions for industrial-scale optimization of the VMAE extraction of bioactive phytochemicals.…”

Section: Discussionmentioning

confidence: 99%

Optimization of the Vacuum Microwave Assisted Extraction of the Natural Polyphenols and Flavonoids from the Raw Solid Waste of the Pomegranate Juice Producing Industry at Industrial Scale

et al. 2021

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Pomegranate pomace (PP) is the solid waste produced in bulk by the pomegranate juice industry which is rich in polyphenols and flavonoids that can replace the hazardous chemical antioxidants/antimicrobials currently used in the agro-food and cosmetics sectors. In the present work, the vacuum microwave assisted extraction (VMAE) of natural antioxidants from raw pomegranate pomace was investigated and successfully optimized at an industrial scale. For the optimization of PP VMAE a novel, highly accurate response surface methodology (RSM) based on a comprehensive multi-point historical design was employed. The optimization showed that the maximum recovery of PP total polyphenols as well as total PP flavonoids were obtained at microwave power = 4961.07 W, water to pomace ratio = 29.9, extraction time = 119.53 min and microwave power = 4147.76 W, water to pomace ratio = 19.32, extraction time = 63.32 min respectively. Moreover, the optimal VMAE conditions on economic grounds were determined to be: microwave power = 2048.62 W, water to pomace ratio = 23.11, extraction time = 15.04 min and microwave power = 4008.62 W, water to pomace ratio = 18.08, extraction time = 15.29 min for PP total polyphenols and PP total flavonoids respectively. The main conclusion of this study is that the VMAE extraction can be successfully used at industrial scale to produce, in economic manner, high added value natural extracts from PP pomace.

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“…This tool describes the interactional effects between a set of data and can be used to generate models for the prediction of the responses [ 25 ]. Previous RSM-based optimization of M. pudica extraction methods used methanol as the sole solvent while incorporating microwave-assisted extraction to obtain maximum antioxidative compounds [ 26 ]. Although the results seemed promising, other solvents, such as ethanol, have yet to be tuned using the same optimization method.…”

Section: Introductionmentioning

confidence: 99%

Response Surface Optimization of Extraction Conditions and In Vitro Antioxidant and Antidiabetic Evaluation of an Under-Valued Medicinal Weed, Mimosa pudica

Baharuddin

Roslan

Bawzer

et al. 2021

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Mimosa pudica Linn is a well-known perennial herb and is traditionally used in ayurvedic medicine for the treatment of various illnesses. Despite its abundance in nature, the therapeutic potential of this invasive weed is deemed to be underappreciated in Malaysia. Previous studies have found an abundance of bioactive compounds associated with potent antioxidant properties in all parts of the plant. However, the optimum parameters required for the extraction of antioxidant compounds are still unknown. Therefore, the present study aimed to optimize the solvent extraction parameters of M. pudica using response surface methodology to enrich the accumulation of antioxidant compounds in the extracts. The effects of the optimized M. pudica extracts were then evaluated on the cell viability and glucose uptake ability in a 3T3-L1 adipocyte cell line. The highest total phenolic (91.98 mg of gallic acid equivalent per g of the dry extract) and total flavonoid content (606.31 mg of quercetin equivalent per g of the dry extract) were recorded when using 100% ethanol that was five-fold and three-fold higher, respectively, as compared to using 50% ethanol. The extract concentration required to achieve 50% of antioxidant activity (IC50 value) was 42.0 µg/mL using 100% ethanol as compared to 975.03 µg/mL using 50% ethanol. The results indicated that the use of 100% ethanol solvent had the greatest impact on the accumulation of antioxidant compounds in the extract (p < 0.05). Cell viability assay revealed that all extract concentration treatments recorded a viability level of above 50%. Glucose uptake assay using 2-NBDG analog showed that the cells treated with 50 µg/mL extract combined with insulin were five-fold higher than the control group. Given the high antioxidant and antidiabetic properties of this plant, M. pudica can be easily highlighted as a plant subject of interest, which warrants further investigation for nutraceutical prospects.

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Optimization and analysis of microwave-assisted extraction of bioactive compounds from Mimosa pudica L. using RSM & ANFIS modeling

Cited by 44 publications

References 29 publications

Optimization of Vacuum-Microwave-Assisted Extraction of Natural Polyphenols and Flavonoids from Raw Solid Waste of the Orange Juice Producing Industry at Industrial Scale

Optimization of Vacuum-Microwave-Assisted Extraction of Natural Polyphenols and Flavonoids from Raw Solid Waste of the Orange Juice Producing Industry at Industrial Scale

Optimization of the Vacuum Microwave Assisted Extraction of the Natural Polyphenols and Flavonoids from the Raw Solid Waste of the Pomegranate Juice Producing Industry at Industrial Scale

Response Surface Optimization of Extraction Conditions and In Vitro Antioxidant and Antidiabetic Evaluation of an Under-Valued Medicinal Weed, Mimosa pudica

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