Optimization and Characterization of a Sphingomyelin/Cholesterol Liposome Formulation of Vinorelbine with Promising Antitumor Activity

Semple, Sean C.; Leone, Robert D.; Wang, Jinfang; Leng, Esther; Klimuk, Sandra K.; Eisenhardt, Merete L.; Yuan, Zuan-Ning; Edwards, Katarina; Maurer, Norbert; Hope, Michael J.; Cullis, Pieter R.; Ahkong, Quet-Fah

doi:10.1002/jps.20332

Cited by 93 publications

(45 citation statements)

References 39 publications

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“…The existence of aggregation for star-(PCL-b-PEG) 4 which was observed in the DLS data in our study, suggested that some star-shaped unimers interact with each other from their hydrophobic PCL sides via hydrophobic-hydrophobic or van der Waals attractions and this causes the occurrence of some particles other than spherical micelles [7,8]. As it has been well demonstrated, these large associations form in the organic solvent of polymeric materials with the adding of first drops of water [50] during the micelle preparation process.…”

Section: Discussionsupporting

confidence: 60%

“…The micelle size distributions of polymeric micelles of both star and Y-shaped polymers with a concentration of 20 mg/mL [8] were determined by DLS and is shown in Figure 9. The micellar size of particles made of star-shaped micelle has a bimodal distribution with a size of 59 and 278 nm and the micelles formed from Y-shaped polymer shows a monomodal distribution with the effective hydrodynamic diameter of 114 nm.…”

Section: Particle Size Determinationmentioning

confidence: 99%

“…The reason for existence of aggregation for star-(PCL-b-PEG) 4 is discussed in conclusion part of the paper. In a summary, it is possible that the star-shaped unimers interact with each other on the exposed hydrophobic PCL sides and make amorphous particles [7,8].…”

Section: Particle Size Determinationmentioning

confidence: 99%

“…This method is based on the changes in the spectroscopic properties of pyrene upon its transfer from aqueous environment to the nonpolar environment of the micellar core [8,47]. Introducing pyrene to a nonpolar environment (the core of the micelle) causes an increase in the intensity of the fluorescence maximum (I 1 ) in the emission spectrum of pyrene.…”

Section: Determination Of the Critical Micelle Concentration (Cmc)mentioning

confidence: 99%

“…Star-shaped block copolymers with a core consisting of hydrophobic inner branches and multiple hydrophilic poly(ethylene glycol) (PEG) tails have been synthesized in the range of 3 to 32 by Wang et al [7,8], Zheng et al [9] and some other groups [10][11][12][13][14][15][16]. The unimers with arm numbers of 16 or 32 have shown the high stability, drug delivery efficacy and physicochemical properties compared to unimers with a smaller arm number.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and Characterization of Biodegradable Amphiphilic Star and Y-Shaped Block Copolymers as Potential Carriers for Vinorelbine

et al. 2014

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Two amphiphilic block copolymers using hydrophobic poly(ε-caprolactone) (PCL) and hydrophilic poly(ethylene glycol) (PEG) were successfully synthesized. One of them is an (A-b-B) 4 type star polymer [(PCL-b-PEG) 4 ] and the other one is a Y-shaped PEG-(PCL) 2 . A star-shaped polymer (PCL-b-PEG) 4 was prepared by ring-opening polymerization (ROP) of ε-caprolactone continued by click reaction of (PCL-azide) 4 and PEG-alkyne. The synthesis of Y-shaped PEG-(PCL) 2 block copolymer was carried out via Diels-Alder click reaction of a furan protected maleimide end-functionalized PEG (PEG-MI) with an anthracene end-functionalized PCL following the ROP of ε-caprolactone. The characterization of micelles is carried out using both materials in aqueous media as drug delivery vehicles, which showed satisfying results and enhanced the cytotoxic effect of the OPEN ACCESSPolymers 2014, 6 215 anti-cancer drug vinorelbine (VLB). However, micelles consisted of Y-shaped unimers were found to be more convenient for delivery of hydrophobic drugs such as VLB because they formed in lower concentration, carrying a higher amount of drugs and owing a monomodal distribution. We concluded that the free tails of hydrophobic chains in Y-shaped block copolymer facilitate the assembly of amphiphilic material in water to form micelles.

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Section: Discussionsupporting

confidence: 60%

Section: Particle Size Determinationmentioning

confidence: 99%

Section: Particle Size Determinationmentioning

confidence: 99%

Section: Determination Of the Critical Micelle Concentration (Cmc)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Synthesis and Characterization of Biodegradable Amphiphilic Star and Y-Shaped Block Copolymers as Potential Carriers for Vinorelbine

et al. 2014

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Pharmacokinetics and in vivo drug release rates in liposomal nanocarrier development

Drummond

Noble

Hayes

et al. 2008

Journal of Pharmaceutical Sciences

256

217

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Nanomaterial Preparation by Extrusion through Nanoporous Membranes

Guo

Huang

Zhao

et al. 2018

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Template synthesis represents an important class of nanofabrication methods. Herein, recent advances in nanomaterial preparation by extrusion through nanoporous membranes that preserve the template membrane without sacrificing it, which is termed as "non-sacrificing template synthesis," are reviewed. First, the types of nanoporous membranes used in nanoporous membrane extrusion applications are introduced. Next, four common nanoporous membrane extrusion strategies: vesicle extrusion, membrane emulsification, precipitation extrusion, and biological membrane extrusion, are examined. These methods have been utilized to prepare a wide range of nanomaterials, including liposomes, emulsions, nanoparticles, nanofibers, and nanotubes. The principle and historical context of each specific technology are discussed, presenting prominent examples and evaluating their positive and negative features. Finally, the current challenges and future opportunities of nanoporous membrane extrusion methods are discussed.

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Optimization and Characterization of a Sphingomyelin/Cholesterol Liposome Formulation of Vinorelbine with Promising Antitumor Activity

Cited by 93 publications

References 39 publications

Synthesis and Characterization of Biodegradable Amphiphilic Star and Y-Shaped Block Copolymers as Potential Carriers for Vinorelbine

Synthesis and Characterization of Biodegradable Amphiphilic Star and Y-Shaped Block Copolymers as Potential Carriers for Vinorelbine

Pharmacokinetics and in vivo drug release rates in liposomal nanocarrier development

Nanomaterial Preparation by Extrusion through Nanoporous Membranes

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