Optimization and evaluation of ciprofloxacin-loaded collagen/chitosan scaffolds for skin tissue engineering

Tripathi, Satyavrat; Singh, B. N.; Singh, Divakar; Kumar, Gaurav; Srivastava, Pradeep

doi:10.1007/s13205-020-02567-w

Cited by 16 publications

(7 citation statements)

References 66 publications

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“…Collagen/CS scaffolds loaded with CPFX were prepared by freeze-drying. The scaffolds were highly biocompatible (fibroblast cells) and efficient against E. coli and S. aureus [ 320 ]. In a new approach, collagen/CS oxygenating scaffolds loaded with the same antibiotic were prepared with calcium peroxide as a chemical oxygen source [ 321 ].…”

Section: Antimicrobial Scaffolds For Tissue Engineeringmentioning

confidence: 99%

“…The approaches reported by the in vivo assays also showed good wound healing efficacy [ 293 , 299 , 302 , 303 ]. Finally, biocompatibility of antibacterial scaffolds prepared by combining strategies and alternative methods has been evaluated using fibroblasts (both human and murine) [ [307] , [308] , [309] , 312 , 314 , 320 ], fibroblast-like cells [ 316 , 321 , 322 ], epithelial cells [ 306 ], osteoblasts [ 312 ], and also Schwann cells [ 318 ] and red blood cells [ 322 ]. In vivo experiments showed the effectiveness of the technique in wound healing in the mouse model [ 307 , 316 ], absorbable sutures in a rabbit model [ 318 ] and a bacterial infection model performed on rats [ 322 ].…”

Section: Toxicological Aspectsmentioning

confidence: 99%

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Scaffolds in the microbial resistant era: Fabrication, materials, properties and tissue engineering applications

Serrano‐Aroca

Cano-Vicent

Serra

et al. 2022

Materials Today Bio

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Section: Antimicrobial Scaffolds For Tissue Engineeringmentioning

confidence: 99%

Section: Toxicological Aspectsmentioning

confidence: 99%

Scaffolds in the microbial resistant era: Fabrication, materials, properties and tissue engineering applications

Serrano‐Aroca

Cano-Vicent

Serra

et al. 2022

Materials Today Bio

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“…43,46 These components aim to, among other actions, reduce inflammatory conditions, provide antimicrobial activity or signal to specific pathways to aid in tissue regeneration. 16,40,42,43,46 In addition, some systems also use micro or nanoparticles as a mechanical reinforcing agent or target local biological activities such as antimicrobial activity. 16,47,48 Among the many formulations in existence, systems based on chitosan stand out due to the biological properties presented by this polymeric matrix, which grant significant improvements in healing time, as will be discussed in the following topics.…”

Section: Dressing Systems For Skin Regenerationmentioning

confidence: 99%

“…38 Many compositions have been evaluated for these systems, including various natural 16,39 and synthetic polymeric matrices 40,41 along with a large array of therapeutic agents that mainly include the use of biomolecules, 16,42 biomimetic components, 40,43 natural, 44,45 and synthetic actives. 43,46 These components aim to, among other actions, reduce inflammatory conditions, provide antimicrobial activity or signal to specific pathways to aid in tissue regeneration. 16,40,42,43,46 In addition, some systems also use micro or nanoparticles as a mechanical reinforcing agent or target local biological activities such as antimicrobial activity.…”

Section: Dressing Systems For Skin Regenerationmentioning

confidence: 99%

Dressing systems based on chitosan as active transport platforms in the treatment of burnt skin: Mini‐review

Muniz

Menezes

2022

Polymers for Advanced Techs

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Burns are one of the most common injuries worldwide, affecting thousands of people every year. These wounds, when more severe, can pose a risk to the individual's systemic health and lead to many hospital visits. Among the possible complications arising from cases of deep or generalized burns, sepsis, scar tissue contraction after inadequate healing, and burn shock caused by hypovolemia stand out. Burnt skin is extremely susceptible to bacteria and other pathogens, due to the loss of the protection provided by intact layers of skin, which can severely hinder its proper healing. Several strategies can be used to treat these injuries, among which, the use of hydrogel‐based dressings stands out because of the wet wound healing process. Thus, many studies have focused on the therapeutic effects of chitosan‐based hydrogels for better wound healing due to the good characteristics of this matrix, which include the high biocompatibility, antimicrobial activity, and ability to act as a carrier for the local delivery of actives. In this perspective, studies that explore hydrogel formulations containing chitosan showed the high versatility of these systems that have already been used as transport platforms for natural actives, biomolecules, synthetic antimicrobials, and even antimicrobial nanoparticles. The results of these studies indicate that the use of dressings based on hydrogels containing chitosan can accelerate the healing of wounds caused by burns in the animal model and achieve synergistic antimicrobial effects with some actives, indicating that chitosan hydrogels hold great promise in developing healing systems to regenerate burnt skin

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“…By adjusting the material ratio, the porosity, strength, and degradation rate can be regulated. [25][26] Therefore, chitosan, gelatin, and silica membranes were used to construct multilayer tissue engineering scaffolds carrying MFUS harvested from rat tail skin, providing space for MFUS growth on SD rats dorsal wound model. Under limited autologous skin source conditions, MFUS tissue-engineered skin that had complete skin structure and function was successfully constructed with the following results.…”

Section: Introductionmentioning

confidence: 99%

Chitosan/Gelatin Composite Nonwoven Fabric Scaffold Seeding Minimal Function Unit of Skin for Functional Skin Regeneration

Chang

Zhang

et al. 2022

Macromolecular Bioscience

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The construction of intact functional skin is a challenging field in tissue engineering. Traditional skin tissue engineering, using "seed cells" as a bioactive source for scaffolding materials maybe not efficient enough. Here a new strategy is shown for constructing functional tissue-engineered skin with Minimal Functional Unit of Skin (MFUS) as the source of bioactivity. Chitosan/gelatin non-woven fabric is used as the scaffold. MFUS is derived from autologous skin with full-thickness skin microstructure and complete functional skin unit harvesting. A mathematical model is used to calculate the MFUS Minimal Harvest Diameter and Angle (MHDA). Chitosan/gelatin non-woven fabric (CS+GEL) is porous and absorbable, with an elastic modulus meeting the requirement of skin engineering. It supports layered and 3D growth of MFUS. The degradation rate of chitosan, including filament diameter and density is evaluated in vivo. MFUS-engineered skin could reduce the density of local nerve fibers in the early stage, potentially reducing pain during wound healing, as well as could limit excessive fibroblast cell migration in the later stage, potentially reducing scar formation. This study proposes a new strategy for the clinical treatment of large full-thickness skin defects by constructing intact functional at minimal cost.

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Optimization and evaluation of ciprofloxacin-loaded collagen/chitosan scaffolds for skin tissue engineering

Cited by 16 publications

References 66 publications

Scaffolds in the microbial resistant era: Fabrication, materials, properties and tissue engineering applications

Scaffolds in the microbial resistant era: Fabrication, materials, properties and tissue engineering applications

Dressing systems based on chitosan as active transport platforms in the treatment of burnt skin: Mini‐review

Chitosan/Gelatin Composite Nonwoven Fabric Scaffold Seeding Minimal Function Unit of Skin for Functional Skin Regeneration

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