Optimization and modeling of microwave-assisted extraction of curcumin and antioxidant compounds from turmeric by using natural deep eutectic solvents

Doldolova, Khadija; Bener, Mustafa; Lalikoğlu, Melisa; Aşçı, Yavuz Selim; Arat, Refik; Apak, Reşat

doi:10.1016/j.foodchem.2021.129337

Cited by 133 publications

(70 citation statements)

References 54 publications

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“…Doldolova et al [ 65 ] studied the curcumin and antioxidant extraction capacity of five different DESs from turmeric ( Curcuma longa ) utilizing microwave-assisted extraction. It is important to note that polyphenols are not the only antioxidants present in turmeric, as several other non-phenolic compounds also exhibit antioxidant activity [ 95 ].…”

Section: Phenolic Compound Extraction From Natural Sourcesmentioning

confidence: 99%

Latest Insights on Novel Deep Eutectic Solvents (DES) for Sustainable Extraction of Phenolic Compounds from Natural Sources

et al. 2021

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Phenolic compounds have long been of great importance in the pharmaceutical, food, and cosmetic industries. Unfortunately, conventional extraction procedures have a high cost and are time consuming, and the solvents used can represent a safety risk for operators, consumers, and the environment. Deep eutectic solvents (DESs) are green alternatives for extraction processes, given their low or non-toxicity, biodegradability, and reusability. This review discusses the latest research (in the last two years) employing DESs for phenolic extraction, solvent components, extraction yields, extraction method characteristics, and reviewing the phenolic sources (natural products, by-products, wastes, etc.). This work also analyzes and discusses the most relevant DES-based studies for phenolic extraction from natural sources, their extraction strategies using DESs, their molecular mechanisms, and potential applications.

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Section: Phenolic Compound Extraction From Natural Sourcesmentioning

confidence: 99%

Latest Insights on Novel Deep Eutectic Solvents (DES) for Sustainable Extraction of Phenolic Compounds from Natural Sources

et al. 2021

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“…The plant occurs naturally throughout many tropical and subtropical regions of the world and has been used in Ayurveda and traditional Chinese medicine for thousands of years to treat inflammatory disease(s) and bacterial infection(s) [ 32 , 33 ]. Since the first reported extraction and separation of CUR around 1815, novel, facile, efficient and sophisticated extraction procedures continue to be developed [ 26 , 34 , 35 , 36 ]. The most commonly reported extraction method for CUR from turmeric makes use of solvent extraction procedures followed by column chromatography.…”

Section: Origin Extraction and Therapeutic Properties Of Curcuminmentioning

confidence: 99%

“…Natural deep eutectic solvents (NADES) are gaining popularity as novel green materials used in the food, cosmetic and pharmaceutical industry. NADES exhibit unique solvation properties with associated low toxicity and have been used in the extraction of CUR [ 35 , 39 , 40 ]. When compared to CUR extracted using conventional extraction solvents the CUR extracted using NADES exhibited greater total antioxidant capacity and higher CUR payload [ 35 , 40 ].…”

Section: Origin Extraction and Therapeutic Properties Of Curcuminmentioning

confidence: 99%

“…NADES exhibit unique solvation properties with associated low toxicity and have been used in the extraction of CUR [ 35 , 39 , 40 ]. When compared to CUR extracted using conventional extraction solvents the CUR extracted using NADES exhibited greater total antioxidant capacity and higher CUR payload [ 35 , 40 ]. Apart from improving the solubility and stability of CUR [ 39 ] NADES extracts exhibited increased antioxidant activity possibly due to enhanced bioavailability resulting from the effect of NADES during antioxidant membrane transport [ 35 ].…”

Section: Origin Extraction and Therapeutic Properties Of Curcuminmentioning

confidence: 99%

“…When compared to CUR extracted using conventional extraction solvents the CUR extracted using NADES exhibited greater total antioxidant capacity and higher CUR payload [ 35 , 40 ]. Apart from improving the solubility and stability of CUR [ 39 ] NADES extracts exhibited increased antioxidant activity possibly due to enhanced bioavailability resulting from the effect of NADES during antioxidant membrane transport [ 35 ]. Furthermore, Soxhlet [ 41 ], ultrasound [ 42 ], microwave [ 43 ], pH-zone-refining [ 44 ] and supercritical carbon dioxide [ 45 ] extraction methods of CUR have been reported.…”

Section: Origin Extraction and Therapeutic Properties Of Curcuminmentioning

confidence: 99%

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Enhancement of Biological and Pharmacological Properties of an Encapsulated Polyphenol: Curcumin

et al. 2021

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There is a dearth of natural remedies available for the treatment of an increasing number of diseases facing mankind. Natural products may provide an opportunity to produce formulations and therapeutic solutions to address this shortage. Curcumin (CUR), diferuloylmethane; I,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione is the major pigment in turmeric powder which has been reported to exhibit a number of health benefits including, antibacterial, antiviral, anti-cancer, anti-inflammatory and anti-oxidant properties. In this review, the authors attempt to highlight the biological and pharmacological properties of CUR in addition to emphasizing aspects relating to the biosynthesis, encapsulation and therapeutic effects of the compound. The information contained in this review was generated by considering published information in which evidence of enhanced biological and pharmacological properties of nano-encapsulated CUR was reported. CUR has contributed to a significant improvement in melanoma, breast, lung, gastro-intestinal, and genito-urinary cancer therapy. We highlight the impact of nano-encapsulated CUR for efficient inhibition of cell proliferation, even at low concentrations compared to the free CUR when considering anti-proliferation. Furthermore nano-encapsulated CUR exhibited bioactive properties, exerted cytotoxic and anti-oxidant effects by acting on endogenous and cholinergic anti-oxidant systems. CUR was reported to block Hepatitis C virus (HCV) entry into hepatic cells, inhibit MRSA proliferation, enhance wound healing and reduce bacterial load. Nano-encapsulated CUR has also shown bioactive properties when acting on antioxidant systems (endogenous and cholinergic). Future research is necessary and must focus on investigation of encapsulated CUR nano-particles in different models of human pathology.

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An antioxidative potential‐based comparison of different peanut extraction methods, optimized through response surface methodology

Jitrangsri,

Chaidedgumjorn,

Satiraphan

2023

Journal of Chemometrics

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In this research, response surface methodology was employed in order to find the most efficient conditions to produce peanut extracts with the highest antioxidative potential (by DPPH, ABTS, FRAP, and ORAC tests) from ultrasound‐assisted (UAE) and microwave‐assisted (MAE) extractions. The optimal conditions for UAE were 75 ml of 30%v/v ethanol as extraction solvent, extraction temperature of 65°C, and 180 min extraction time. Optimal conditions for MAE were 15 ml of 30%v/v ethanol as extraction solvent, extraction temperature of 80°C, and 90 s extraction time. The generated models presented a reliable antioxidative response by showing non‐difference between experimental and predicted values within a 95% confidence level. Characteristics such as antioxidant activities, TPC, resveratrol, and TFC were used to compare the effectiveness of the obtained extracts and the SLE extract from our previous work. The UAE extract displayed higher extraction efficiency than that of MAE in terms of higher levels of all responses (p < 0.05). Slightly lower antioxidant values of MAE might be due to the limited solvent volume used, which was five times less than that of UAE. Moreover, the high efficacy of MAE was confirmed by its extraction time, which was 120 times shorter than that of UAE. Ultimately, the correlation analysis implied that the antioxidant activity of peanut extracts was contributed by TPC rather than resveratrol or TFC, and the revealed TPC in this study was higher than previous reports.

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Optimization and modeling of microwave-assisted extraction of curcumin and antioxidant compounds from turmeric by using natural deep eutectic solvents

Cited by 133 publications

References 54 publications

Latest Insights on Novel Deep Eutectic Solvents (DES) for Sustainable Extraction of Phenolic Compounds from Natural Sources

Latest Insights on Novel Deep Eutectic Solvents (DES) for Sustainable Extraction of Phenolic Compounds from Natural Sources

Enhancement of Biological and Pharmacological Properties of an Encapsulated Polyphenol: Curcumin

An antioxidative potential‐based comparison of different peanut extraction methods, optimized through response surface methodology

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