Optimization and Validation of the Spectrophotometric Methods for the Assay of Dexmedetomidine Hydrochloride in Pure and Dosage Forms

Roopa, K. P.; Basavaiah, K.; Jayanna, B.K.

doi:10.1007/s10812-019-00888-0

Cited by 6 publications

(1 citation statement)

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“…NBS is widely used as a good oxidizing agent for many organic compounds. We have previously demonstrated the applicability of NBS for the determination of such drugs as dexmedetomidine hydrochloride [33], phenylephrine hydrochloride and pyridoxine hydrochloride [34]. NBS was also used in the determination of many compounds including pizotifen maleate [35], metaprolal tartrate [36], ofloxacin [37], pantoprazole sodium [38], gemifloxacin mesylate and moxifloxacin HCl [39] as well as fluoroquinolone [40].…”

Section: Articlesmentioning

confidence: 99%

Determination of Solifenacin Succinate in Pure and Pharmaceutical Dosage forms by Spectrophotometry

Papanna¹,

Basavaiah

Gowda³

et al. 2021

J Anal Chem

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Four simple, precise and sensitive visible spectrophotometric methods were developed for the determination of solifenacin succinate in pure and pharmaceutical dosage forms. The proposed methods were based on the estimation of unreacted N-bromosuccinimide (NBS) with four dyes, namely, amaranth, safranin, aniline blue and rhodamine B, by the drug oxidation by known excess of NBS at laboratory temperature. Beer-Lambert's law revealed good correlation in the concentration ranges of 10-70, 20-80, 30-80, and 10-50 μg/mL for methods A, B, C and D, respectively. The developed methods were successfully applied to the determination of solifenacin succinate in commercially available dosage forms. Statistical comparison of the results showed insignificant difference between the proposed methods and reference method. The proposed methods offered the advantages of simplicity and economy that can be applied without the need for expensive instrumentation and reagents in quality control analysis.

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