Optimization of a capillary electrophoresis method to determine the chiral purity of a drug

Rickard, Eugene C.; Bopp, Ronald J.

doi:10.1016/0021-9673(94)85161-1

Cited by 59 publications

(23 citation statements)

References 34 publications

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“…Cyclodextrins are the most popular chiral selectors because of their good selectivity, reasonable solubility and good UV transparency. Recent examples of the use of cyclodextrins are in the analysis of pharmaceuticals and herbicides [7,81. Other chiral selectors of promise are the proteins such as bovine serum albumin [9] and cellulase [lo], and the antibiotics Vancomycin [ll] and Ristocetin [12].…”

Section: Introductionmentioning

confidence: 99%

Chiral separation in capillary electrophoresis

Wren

1995

Electrophoresis

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Section: Introductionmentioning

confidence: 99%

Chiral separation in capillary electrophoresis

Wren

1995

Electrophoresis

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“…Experiments revealed that resolution and migration times were essentially constant when the sample concentration was low, but varied substantially at high sample concentrations, as can be seen in Figure 1. This phenomenon was also observed by Rickard and Bopp [24]. Wren and Rowe [3,4] derived an equation for optimization of selector concentration which is valid for an uncharged chiral selector only.…”

Section: Optimization Of the Separationmentioning

confidence: 66%

Separation of chiral basic drugs with sulfobutyl-β-cyclodextrin in capillary electrophoresis

et al. 1999

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SummarySeparation of the enantiomers of 22 chiral basic drugs not previously separated with sulfobutyl-fl-cyclodextrin (SBE-fl-CD) as a chiral selector has been investigated by capillary zone electrophoresis. By dissolving the drug in Britton-Robinson buffer then optimization of selector concentration, pH, and amount injected, the enantiomers of 19 drugs were successfully separated, two for the first time.

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“…According to this paper, several different CDs are suitable for the enantioseparation of DLX. As early as 1994, the drug manufacturer published a paper on the chiral analysis of DLX [60]. The separation was obtained using hydroxypropyl-b-CD as the selector and the authors claim that it is advantageous with respect to those obtained by chiral HPLC, due to the higher number of theoretical plates, smaller amounts of chiral additive needed and greater ruggedness.…”

Section: Serotonin and Norepinephrine Reuptake Inhibitorsmentioning

confidence: 98%

Advances in the enantioseparation of second‐generation antidepressant drugs by electrodriven methods

Mandrioli

Raggi

2006

Electrophoresis

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Stereochemistry is steadily increasing in importance in the development of new drugs, and the availability of pure enantiomer drugs can make therapy safer and more efficacious. In particular, almost all second-generation antidepressant drugs possess one or more chiral centres; however, only some of them are administered as single enantiomers. A fundamental part of the quality control of pharmaceutical formulations is the determination of enantiomeric excess and enantiomeric purity; this is also important for the therapeutic drug monitoring of depressed patients. For this purpose, efficient and reliable analytical methods are needed and electrodriven techniques (most of all CE, CEC and MEKC) are very efficient and inexpensive candidates for the role. In this review, the enantioselective electrodriven methods available for the analysis of second-generation antidepressant are presented and discussed. In particular, the following pharmacological classes of antidepressants will be considered: selective serotonin reuptake inhibitors (fluoxetine, citalopram, paroxetine, sertraline); norepinephrine reuptake inhibitors (reboxetine); serotonin and norepinephrine reuptake inhibitors (venlafaxine, milnacipran, duloxetine); and noradrenergic and specific serotonergic antidepressants (mirtazapine).

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Optimization of a capillary electrophoresis method to determine the chiral purity of a drug

Cited by 59 publications

References 34 publications

Chiral separation in capillary electrophoresis

Chiral separation in capillary electrophoresis

Separation of chiral basic drugs with sulfobutyl-β-cyclodextrin in capillary electrophoresis

Advances in the enantioseparation of second‐generation antidepressant drugs by electrodriven methods

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