Optimization of carbon source and carbon/nitrogen ratio for cordycepin production by submerged cultivation of medicinal mushroom Cordyceps militaris

Mao, Xian-Bing; Eksriwong, Titiporn; Chauvatcharin, Somchai; Zhong, Jian‐Jiang

doi:10.1016/j.procbio.2004.06.046

Cited by 165 publications

(106 citation statements)

References 21 publications

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“…For using the mycelial biomasses, it is necessary to prove that they are similar to the mushroom. Some studies have already shown that the mycelial biomasses of different medicinal fungi possess pharmacologic properties comparable to those of the mushroom [72][73][74][75][76][77]. Around 15% of the bioactives are presently derived from mycelial extracts of mushrooms [11], but this fraction tends to increase considering the positive results that were obtained by several research groups and the great number of investigators working in this field.…”

Section: Obtainment Of Fungi Extracts: Basidioma or Ascoma Versus Mycmentioning

confidence: 99%

Hepatoprotective Effects of Mushrooms

et al. 2013

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Abstract:The particular characteristics of growth and development of mushrooms in nature result in the accumulation of a variety of secondary metabolites such as phenolic compounds, terpenes and steroids and essential cell wall components such as polysaccharides, β-glucans and proteins, several of them with biological activities. The present article outlines and discusses the available information about the protective effects of mushroom extracts against liver damage induced by exogenous compounds. Among mushrooms, Ganoderma lucidum is indubitably the most widely studied species. In this review, however, emphasis was given to studies using other mushrooms, especially those presenting efforts of attributing hepatoprotective activities to specific chemical components usually present in the mushroom extracts.

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Section: Obtainment Of Fungi Extracts: Basidioma or Ascoma Versus Mycmentioning

confidence: 99%

Hepatoprotective Effects of Mushrooms

et al. 2013

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“…More than 10 million metric tons of edible and medicinal mushrooms are cultivated annually worldwide. Products from cultivated mushrooms have been used extensively as food additives, health foods, and for medicinal purposes to treat cancers and circulatory disorders (Kim et al, 2003;Mao et al, 2005;Park et al, 2001). Improvements in mushroom cultivation technology have brought countless benefits to commercial production and laboratory applications of mushroom.…”

Section: Functional Mushroomsmentioning

confidence: 99%

Fibrinolytic Enzymes from Medicinal Mushrooms

Lu¹,

Chen²

2012

Protein Structure

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“…Glucose was found to be significant and yeast extract non-significant, which was similar to the results obtained in this study. In a similar study done by Mao et al [18], on Cordyceps militaris, central composite design was conducted to locate the optimum concentrations of glucose and peptone for cordycepin production.…”

Section: Central Composite Designmentioning

confidence: 99%

Statistical optimization of culture conditions for enhanced mycelial biomass production using Ganoderma lucidum

2018

J App Biol Biotech

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The study aimed at optimizing the mycelial biomass production of Ganoderma lucidum by submerged fermentation. Plackett-Burman design was used to screen the important growth conditions coupled with central composite design to study the interaction of various variables with one another. Using Plackett-Burman design, temperature, yeast extract concentration, and glucose concentration were found to be significant variables contributing the most to biomass production. The R 2 value of the model was 0.9623 which indicated that the model is good. These three variables were used for further optimization studies by central composite design. Through central composite design, temperature and glucose concentration were found to be the most significant factors affecting the mycelial biomass of G. lucidum. The overall model was found to be statistically significant with a P < 0.0001. Statistical optimization was found to be an effective tool as it helped to increase the biomass production significantly.

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Optimization of carbon source and carbon/nitrogen ratio for cordycepin production by submerged cultivation of medicinal mushroom Cordyceps militaris

Cited by 165 publications

References 21 publications

Hepatoprotective Effects of Mushrooms

Hepatoprotective Effects of Mushrooms

Fibrinolytic Enzymes from Medicinal Mushrooms

Statistical optimization of culture conditions for enhanced mycelial biomass production using Ganoderma lucidum

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