Optimization of cisplatin for the treatment of hormone-dependent tumoral diseases

Synthesis, characterization, structure, molecular modeling studies and biological activity of sterically crowded Pt(II) complexes containing bis(imidazole) ligands

“…This activity may be related to a combination of different factors: i) the presence of the Joseph ligand may balance the positive charge of 15 resulting in a final log k′ 0 higher than those of the reference compounds cisplatin, carboplatin and oxaliplatin; ii) Pt cationic species may act as substrates for the organic cationic transporters increasing their cellular accumulation bypassing the passive diffusion through the (hydrophobic) cell membrane [30,54]; and iii) inside the cell, the aquated cationic 15 is already in its activated form and may readily react with its final target, the polyanionic DNA [55]. …”

Macrocyclic Complexes: A New Way Forward Into the Medicinal World.

“…has placed coordination chemistry of metal-based drugs in the frontline in the fight against cancer. Although highly effective in treating a variety of cancers, the cure with cis-platin is still limited by dose-limiting side effects (Jung et al, 2007) and inherited or acquired resistance phenomena, only partially amended by employment of new platinum drugs (Gust et al, 2009). These problems have stimulated an extensive search and prompted chemists to develop alternative strategies, based on different metals, with improved pharmacological properties and aimed at different targets.…”

Synthesis, crystal structure, and antitumour activities of cobalt(II) complex based on 2,6-bis(1-phenylbenzimidazol-2-yl)pyridine

“…The cure with cisplatin is still limited by dose limiting side effects and inherited or acquired resis tance phenomena, only partially amended by employ ment of new platinum drugs [3][4][5]. Intensive efforts have been made to develop new metal complexes that are effective against cancer cells either by changing the metal or the ligand type.…”