Optimization of curcumin nanoemulsion for intranasal delivery using design of experiment and its toxicity assessment

Sood, Sumeet; Jain, Kunal; Kuppusamy, Gowthamarajan

doi:10.1016/j.colsurfb.2013.09.030

Cited by 245 publications

(128 citation statements)

References 43 publications

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“…Prior to the preparation of nanoemulsions, selection of the proper surfactants/oil combinations was done based on conduction of preliminary solubility experiments and previously reported research work by other authors (Amri et al, 2014;Sood et al, 2014). Labrafac Lipophile and Labrafac PG were selected as the oily phases, and tween 80 and Cremophor RH 40 were selected as the surfactants for nanoemulsion preparation.…”

Section: Preparation Of Nanoemulsionsmentioning

confidence: 99%

“…Labrafac Lipophile and Labrafac PG were selected as the oily phases, and tween 80 and Cremophor RH 40 were selected as the surfactants for nanoemulsion preparation. The aforementioned excipients were safely utilized for transnasal delivery (Sood et al, 2014). Fifty milligrams of each of curcumin and resveratrol were added to glass vials containing appropriate amounts of oil/surfactant, as shown in Table 1.…”

Section: Preparation Of Nanoemulsionsmentioning

confidence: 99%

“…The co-utilization of the two polyphenols was reported to result in positive synergism in their antioxidant activity (Aftab & Vieira, 2010). Despite their reported efficacy, both drugs suffer from bioavailability problems, owing to their poor water solubility, instability and metabolism (Chen et al, 2013;Vanaja et al, 2013;Amri et al, 2014;Basavaraj & Betageri, 2014;Sood et al, 2014). The encapsulation of these two polyphenols using pharmaceutical carriers has provided a solution to these problems (Vanaja et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

“…The concept of nose to brain targeting in treatment of neurodegenerative disorders has benefited to a great deal from nanotechnology, provided that these nanocarriers overcome the rapid mucociliary clearance and poor nasal absorption (Sood et al, 2013(Sood et al, , 2014. Trans-nasal brain delivery of nanoparticles offers many advantages, such as ease of selfadministration, non-invasiveness as well as effective brain targeting.…”

Section: Introductionmentioning

confidence: 99%

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Development of an optimized hyaluronic acid-based lipidic nanoemulsion co-encapsulating two polyphenols for nose to brain delivery

Nasr

2015

Drug Delivery

171

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RESEARCH ARTICLEDevelopment of an optimized hyaluronic acid-based lipidic nanoemulsion co-encapsulating two polyphenols for nose to brain delivery Maha NasrDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt AbstractThe development of mucoadhesive lipidic nanoemulsion based on hyaluronic acid, co-encapsulating two polyphenols (resveratrol and curcumin) for the transnasal treatment of neurodegenerative diseases was attempted in the current manuscript. Nanoemulsions were prepared by the spontaneous emulsification method, and were characterized for their particle size, zeta potential, mucoadhesive strength and morphology. The selected formula was tested for its antioxidant potential, in vitro and ex vivo release of the two polyphenols, safety on nasal mucosa and in vivo quantification of the two drugs in rat brains. Its stability was tested by monitoring the change in particle size, zeta potential, drugs' content and antioxidant potential upon storage for 3 months. The optimized hyaluronic acid based nanoemulsion formula displayed a particle size of 115.2 ± 0.15 and a zeta potential of À23.9 ± 1.7. The formula displayed a spherical morphology and significantly higher mucoadhesive strength compared to its non mucoadhesive counterpart. In addition, the nanoemulsion was able to preserve the antioxidant ability of the two polyphenols and protect them from degradation. Diffusion controlled release of the two drugs was achievable till 6 hours, with an ex vivo flux across sheep nasal mucosa of 2.86 and 2.09 mg/cm 2 hr for resveratrol and curcumin, respectively. Moreover, the mucoadhesive nanoemulsion was safe on nasal mucosa and managed to increase the amounts of the two polypehnols in the brain (about 7 and 9 folds increase in AUC 0-7 h for resveratrol and curcumin, respectively). Hyaluronic acid based lipidic nanoemulsion proved itself as a successful carrier enhancing the solubility, stability and brain targetability of polyphenols.

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Section: Preparation Of Nanoemulsionsmentioning

confidence: 99%

Section: Preparation Of Nanoemulsionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Development of an optimized hyaluronic acid-based lipidic nanoemulsion co-encapsulating two polyphenols for nose to brain delivery

Nasr

2015

Drug Delivery

171

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“…The permeation profile was constructed by plotting amount of drug permeated per unit skin surface area (µg/cm 2 ) versus time (h). The steady state flux (Jss, mcg/ cm 2 h) was calculated from the slope of the linear portion of the plot using linear regression analysis [17].…”

Section: Sampling Arrangementmentioning

confidence: 99%

Design and Performance Verification of Newly Developed Disposable Static Diffusion Cell for Drug Diffusion/Permeability Studies

Yadav

Garg

Gulati

et al. 2018

Asian J Pharm Clin Res

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Objectives:The present study describes a disposable static diffusion cell for in vitro diffusion studies to achieve better results as compared to well existing Franz diffusion cell (FDC) in terms of the absence of bubbles, variable receptor compartment, ease of handling, and faster results. Materials and Methods:The cell consists of a cup-shaped donor compartment made of semi permeable that could be either cellophane membrane or, animal skin fitted to a rigid frame, which is supported on a plastic plate that contains a hole for the sample withdrawal. The receptor compartment is a separate unit, and it could be any container up to 500ml volume capacity. The most preferred receptor compartment is glass beaker. In the present study, goatskin was used as semi-permeable membrane and verification of its performance was carried out through diffusion studies using gel formulations of one each of the four-selected biopharmaceutical classification system (BCS) class drugs. Metronidazole, diclofenac sodium, fluconazole, and sulfadiazine were used as model drugs for BCS Class I, II, III, and IV, respectively. Results:The newly developed diffusion cell (NDDC) was found to provide faster and more reproducible results as compared to FDC. At the time interval of 24 h, the cell was found to exhibit a higher diffusion of metronidazole, diclofenac sodium, fluconazole, and sulfadiazine by 0.65, 0.65, 0.32, and 0.81 folds, respectively. The faster release obtained with NDDC was attributed to a larger surface area of skin as compared to that in FDC. Conclusion:It was concluded that better reproducibility of results could be achieved with NDDC.

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In Vitro , Ex Vivo and In Vivo Methods for Characterization of Bioadhesiveness of Drug Delivery Systems

Djekić

Mihalj

2020

Bioadhesives in Drug Delivery

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Optimization of curcumin nanoemulsion for intranasal delivery using design of experiment and its toxicity assessment

Cited by 245 publications

References 43 publications

Development of an optimized hyaluronic acid-based lipidic nanoemulsion co-encapsulating two polyphenols for nose to brain delivery

Development of an optimized hyaluronic acid-based lipidic nanoemulsion co-encapsulating two polyphenols for nose to brain delivery

Design and Performance Verification of Newly Developed Disposable Static Diffusion Cell for Drug Diffusion/Permeability Studies

In Vitro , Ex Vivo and In Vivo Methods for Characterization of Bioadhesiveness of Drug Delivery Systems

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