Optimization of Diabetes by Herbal Medicine

Janapati, Yasodha Krishna; Junapudi, Sunil; Dachani, Sudharshan Reddy

doi:10.9734/bpi/tipr/v6/2277e

Cited by 2 publications

(3 citation statements)

References 81 publications

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“…2 Consequently, types of animal models for type 2 diabetes include models of beta cell loss and/or insulin resistance. 44,50,51 Obesity is prevalent in animal models of type 2 diabetes, mimicking the human scenario where obesity is directly associated with the development of type 2 diabetes. 29 4.2.1 | Genetically derived or spontaneous diabetic type 2 animals (obese model)…”

Section: In Vivo Models For Type 2 Diabetesmentioning

confidence: 99%

“…Insulin resistance and the beta cell's failure to produce insulin to compensate are hallmarks of type 2 diabetes 2 . Consequently, types of animal models for type 2 diabetes include models of beta cell loss and/or insulin resistance 44,50,51 . Obesity is prevalent in animal models of type 2 diabetes, mimicking the human scenario where obesity is directly associated with the development of type 2 diabetes 29 …”

Section: Animal Models For Diabetic Researchmentioning

confidence: 99%

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Progress in experimental models to investigate the in vivo and in vitro antidiabetic activity of drugs

Janapati,

Junapudi

2024

Anim Models and Exp Med

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Diabetes mellitus is one of the world's most prevalent and complex metabolic disorders, and it is a rapidly growing global public health issue. It is characterized by hyperglycemia, a condition involving a high blood glucose level brought on by deficiencies in insulin secretion, decreased activity of insulin, or both. Prolonged effects of diabetes include cardiovascular problems, retinopathy, neuropathy, nephropathy, and vascular alterations in both macro‐ and micro‐blood vessels. In vivo and in vitro models have always been important for investigating and characterizing disease pathogenesis, identifying targets, and reviewing novel treatment options and medications. Fully understanding these models is crucial for the researchers so this review summarizes the different experimental in vivo and in vitro model options used to study diabetes and its consequences. The most popular in vivo studies involves the small animal models, such as rodent models, chemically induced diabetogens like streptozotocin and alloxan, and the possibility of deleting or overexpressing a specific gene by knockout and transgenic technologies on these animals. Other models include virally induced models, diet/nutrition induced diabetic animals, surgically induced models or pancreatectomy models, and non‐obese models. Large animals or non‐rodent models like porcine (pig), canine (dog), nonhuman primate, and Zebrafish models are also outlined. The in vitro models discussed are murine and human beta‐cell lines and pancreatic islets, human stem cells, and organoid cultures. The other enzymatic in vitro tests to assess diabetes include assay of amylase inhibition and inhibition of α‐glucosidase activity.

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Section: In Vivo Models For Type 2 Diabetesmentioning

confidence: 99%

Section: Animal Models For Diabetic Researchmentioning

confidence: 99%

Progress in experimental models to investigate the in vivo and in vitro antidiabetic activity of drugs

Janapati,

Junapudi

2024

Anim Models and Exp Med

Self Cite

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“…Diabetes mellitus (DM) is one of the five leading causes of death in the world. 1 The prevalence of diabetes mellitus in the world continues to increase year by year. 2 Abnormal glucose and lipid metabolism in DM patients leads to hyperlipidemia; triglycerides and cholesterol increase significantly; and HDL decreases.…”

Section: Introductionmentioning

confidence: 99%

Combination of purple sweet potato (Ipomoea batatas L.) leaf extract with metformin on blood glucose and total cholesterol levels of albino rats induced by high-fat diet and streptozotocin

Saing,

Harahap,

Sitorus

2024

Int J Basic Clin Pharmacol

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Background: Diabetes mellitus is a metabolic disease characterized by hyperglycemia due to impaired insulin secretion, often accompanied by hypercholesterolemia. Metformin is a first-line antihyperglycemic drug that is often combined with other antihyperglycemic drugs. Purple sweet potato leaves have been widely studied to reduce glucose and cholesterol levels. Methods: This study was an experimental study using rats induced with a high-fat diet and streptozotocin, which were divided into 8 treatment groups, namely groups given CMC Na 0.5%, Metformin 45 mg/kg BW, Purple Sweet Potato Leaf Extract (SPLE) 200 mg/kg BW, SPLE 400 mg/kg BW, SPLE 800 mg/kg BW, SPLE 200 mg/kg BW with metformin 45 mg/kg BW, SPLE 400 mg/kg BW with metformin 45 mg/kg BW, and SPLE 800 mg/kg BW with metformin 45 mg/kg BW. Results: After treatment for 28 days with SPLE doses of 200 mg, 400 mg, and 800 mg/kg BW, both single doses and combinations with metformin showed a decrease in fasting blood glucose levels and total cholesterol, which were statistically significantly different (p<0.05) between treatment groups using the one-way ANOVA. The combination of SPLE 800 mg/kg BW with metformin normalized blood glucose levels of 93.50±4.93 mg/dl.Conclusion: The combination of purple sweet potato leaf extract with metformin is more effective in reducing blood glucose and total cholesterol levels compared to the single administration of metformin and SPLE.

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Optimization of Diabetes by Herbal Medicine

Cited by 2 publications

References 81 publications

Progress in experimental models to investigate the in vivo and in vitro antidiabetic activity of drugs

Progress in experimental models to investigate the in vivo and in vitro antidiabetic activity of drugs

Combination of purple sweet potato (Ipomoea batatas L.) leaf extract with metformin on blood glucose and total cholesterol levels of albino rats induced by high-fat diet and streptozotocin

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