Optimization of Electrode Configuration and Pulse Strength in Irreversible Electroporation for Large Ablation Volumes Without Thermal Damage

Yang, Ye; Möser, Michael; Zhang, Edwin; Zhang, Wenjun; Zhang, Bing

doi:10.1115/1.4038791

Cited by 18 publications

(16 citation statements)

References 33 publications

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“…The general idea was to develop a more accurate mathematical model with which the IRE process can be simulated. This idea is viable, as supported by the literature, e.g., the study to make an optimal pre-clinic IRE treatment planning with a mathematical model [ 8 , 9 ], optimal design of IRE electrodes [ 10 , 11 ], and understanding of the synergistic effectiveness of IRE combined with other treatments [ 3 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Development of a statistical model for cervical cancer cell death with irreversible electroporation in vitro

et al. 2018

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PurposeThe aim of this study was to develop a statistical model for cell death by irreversible electroporation (IRE) and to show that the statistic model is more accurate than the electric field threshold model in the literature using cervical cancer cells in vitro.MethodsHeLa cell line was cultured and treated with different IRE protocols in order to obtain data for modeling the statistical relationship between the cell death and pulse-setting parameters. In total, 340 in vitro experiments were performed with a commercial IRE pulse system, including a pulse generator and an electric cuvette. Trypan blue staining technique was used to evaluate cell death after 4 hours of incubation following IRE treatment. Peleg-Fermi model was used in the study to build the statistical relationship using the cell viability data obtained from the in vitro experiments. A finite element model of IRE for the electric field distribution was also built. Comparison of ablation zones between the statistical model and electric threshold model (drawn from the finite element model) was used to show the accuracy of the proposed statistical model in the description of the ablation zone and its applicability in different pulse-setting parameters.ResultsThe statistical models describing the relationships between HeLa cell death and pulse length and the number of pulses, respectively, were built. The values of the curve fitting parameters were obtained using the Peleg-Fermi model for the treatment of cervical cancer with IRE. The difference in the ablation zone between the statistical model and the electric threshold model was also illustrated to show the accuracy of the proposed statistical model in the representation of ablation zone in IRE.ConclusionsThis study concluded that: (1) the proposed statistical model accurately described the ablation zone of IRE with cervical cancer cells, and was more accurate compared with the electric field model; (2) the proposed statistical model was able to estimate the value of electric field threshold for the computer simulation of IRE in the treatment of cervical cancer; and (3) the proposed statistical model was able to express the change in ablation zone with the change in pulse-setting parameters.

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Section: Introductionmentioning

confidence: 99%

Development of a statistical model for cervical cancer cell death with irreversible electroporation in vitro

et al. 2018

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“…The tumor tissue was set at the middle of the model and was 10.0 mm in length. The other regions were defined as normal tissue (Figure 1(A)) and were considered to have isotropic and homogeneous electrical and thermal properties, as obtained from previous studies [22,[34][35][36][37] and an open database [38] (Table 1). The parameters of the tumor were set similar to those of normal tissue due to lack of model data in literature.…”

Section: Models Of Digestive Tract and Electrodementioning

confidence: 99%

“…where V 0 is the potential difference across the electrodes. The outer boundary of the tissue were set as electrical insulating [24,34,35,41]. The initial temperature of the tissue and artery was set to 37 C (310.15 K), which is the normal physiological body temperature.…”

Section: Boundary and Initial Conditionsmentioning

confidence: 99%

“…The internal boundaries between the tissue and electrodes were defined as thermally continuous. The external boundaries of the tissue and electrodes were defined as adiabatic to confine the heat generated during IRE within the tissue completely, depending on which the upper limits of Joule heating can be calculated [24,35,48].…”

Section: Boundary and Initial Conditionsmentioning

confidence: 99%

“…The model and numerical analyses were constructed and executed using commercial COMSOL Multiphysics 5.4 software (COMSOL, Inc., Burlington, MA). A convergence test of the mesh model was performed to ensure validity and stability of the simulation [24,35]. The detailed data of the mesh model are summarized in the Supplementary Files.…”

Section: Numerical Analysismentioning

confidence: 99%

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Electrical and thermal analyses of catheter-based irreversible electroporation of digestive tract

Ren

Liu

Gao

et al. 2019

International Journal of Hyperthermia

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Introduction: Irreversible electroporation (IRE) combined with a catheter-based electrode during endoscopy is a potential alternative treatment method for digestive tract tumors. The aim of this study was to investigate the electrical injury (EI) and thermal injury (TI) to the digestive tract via numerical analyses and to evaluate the role and impact of electrode configurations and pulse settings on the efficacy and outcomes of IRE. Materials and methods: A finite element method was used to solve the numerical model. A digestive tract model having 4-mm-thick walls and two catheter-based electrode configuration models were constructed. The distributions of electric fields, temperature, electrical conductivity, tissue injury and limitation on the pulse number required for IRE were calculated and compared. Results: Electrode length is an important geometric parameter for electrodes in the monopolar model (MPM), while electrode spacing affects the outcomes in the bipolar model (BPM). Increasing the pulse voltage reduces the pulse number required for tissue ablation, while increasing the risk of TI. In total, there were 6 NT-IRE protocols, 12 thermal-IRE protocols and 30 TI protocols. All of the NT-IRE protocols were set in BPMs with a voltage of 0.50 kV. With increasing electrode spacing, the minimum pulse number decreased. However, thermal effects were inevitable in the MPM. Conclusions: The electrode configuration and pulse settings are adjusted to achieve NT-IRE synergistically. The BPM is more reliable for achieving NT-IRE in 4-mm-thick digestive wall. Future in vitro and in vivo studies are needed to support and validate this conclusion. ARTICLE HISTORY

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Comprehensive review on thermal aspects of nonthermal irreversible electroporation

Wijayanta

Kurata

2023

Heat Trans

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Irreversible electroporation (IRE) is an innovative cell ablation method based on the concept that the application of excessive electric pulses induces a lethal increase in the permeability of the cell membrane owing to nanoscale defects, resulting in a gentle form of necrotic cell death. Although the mechanism of cell death by IRE is primarily nonthermal, thermal effects are inevitable because electric pulses inherently generate Joule heat. The larger the applied voltage to treat a large target, the greater the Joule heating and the consequent temperature rise. Therefore, the temperature increase due to Joule heating during pulse application should be carefully controlled to minimize thermal damage. Research on IRE is an interdisciplinary endeavor incorporating health science for humanitarian relief and engineering. Therefore, this study provides a comprehensive review of the thermal aspects of IRE based on existing in vitro and in vivo experimental and numerical studies. The paper begins with an overview of IRE treatment covering the geometry and arrangement of electrodes, pulse parameters, and cell death mechanisms, followed by sections on thermal damage evaluation that summarize the significant work of experiments, analysis, and comparisons. Finally, thermal mitigation strategies, including electrode modification,

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Optimization of Electrode Configuration and Pulse Strength in Irreversible Electroporation for Large Ablation Volumes Without Thermal Damage

Cited by 18 publications

References 33 publications

Development of a statistical model for cervical cancer cell death with irreversible electroporation in vitro

Development of a statistical model for cervical cancer cell death with irreversible electroporation in vitro

Electrical and thermal analyses of catheter-based irreversible electroporation of digestive tract

Comprehensive review on thermal aspects of nonthermal irreversible electroporation

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