Optimization of extraction process and characterization of water-soluble polysaccharide (Galactomannan) from Algerian biomass; <i>Citrullus colocynthis</i> seeds

Kouadri, Imane; Layachi, Abdelheq; Makhlouf, Azzedine; Satha, Hamid

doi:10.1080/1023666x.2018.1455343

Cited by 19 publications

(22 citation statements)

References 72 publications

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“…The pattern of KCFP had a broad diffraction peak at approximately 2θ = 22° and a shoulder peak at 2θ = 13° ( Figure 1D ), indicating an amorphous nature. The XRD pattern showed no sharp peaks, which indicated that KCFP does not contain crystalline impurities ( 14 ).…”

Section: Resultsmentioning

confidence: 99%

Physicochemical Characterization and Antioxidant and Hypolipidaemic Activities of a Polysaccharide From the Fruit of Kadsura coccinea (Lem.) A. C. Smith

et al. 2022

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Kadsura coccinea fruit, a novel fruit resource, has attracted wide interest, but the physicochemical characteristics and biological activities of its polysaccharides remain unclear. This study investigated the physicochemical properties of a polysaccharide extracted from K. coccinea fruit polysaccharide (KCFP) and evaluated its antioxidant and hypolipidaemic activities in vitro and in vivo. KCFP is an amorphous, thermally stable pectin heteropolysaccharide with an average molecular weight of 204.6 kDa that is mainly composed of mannose, rhamnose, glucose, galactose, xylose, arabinose, galacturonic acid (molar percentage >70%) and glucuronic acid. 2,2-Diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) free radical scavenging assays and an iron reducing antioxidant power assay showed that KCFP has strong antioxidant capacity, while the bile acid binding assay showed that KCFP has hypolipidaemic potential in vitro. The antioxidant and hypolipidaemic activities of KCFP were further evaluated in high-fat diet-induced hyperlipidaemic mice. KCFP significantly increased the activities of superoxide dismutase, glutathione peroxidase and catalase, decreased the malondialdehyde content, significantly reduced the total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) levels, and increased the amount of high-density lipoprotein cholesterol (HDL-C). These findings suggest that KCFP could be used as a functional food to remedy oxidative damage and hyperlipidaemia.

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Section: Resultsmentioning

confidence: 99%

Physicochemical Characterization and Antioxidant and Hypolipidaemic Activities of a Polysaccharide From the Fruit of Kadsura coccinea (Lem.) A. C. Smith

et al. 2022

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“…The FT-IR spectra of DLP-3 are shown in Figure 3 C. The characteristic absorption peaks of DLP-3 can be observed at 3408.75 cm −1 and 2928.27 cm −1 , which are attributed to O-H and C-H groups [ 27 ]. The absorption bands of DLP-3 at 1623.49 cm −1 and 1410.85 cm −1 indicate that there may be -COO- stretching vibration [ 28 ].…”

Section: Resultsmentioning

confidence: 99%

Isolation of a New Polysaccharide from Dandelion Leaves and Evaluation of Its Antioxidant, Antibacterial, and Anticancer Activities

Zhang

et al. 2022

Molecules

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Dandelion, in China, has a long history as a medicinal and edible plant, and possesses high nutritional and medical value. The present study aimed to isolate a new polysaccharide (DLP-3) from dandelion leaves and to evaluate its antioxidant, antibacterial, and anticancer activities. The structure of DLP-3 was analyzed using HPLC, FT-IR, SEM, GC-MS, and NMR spectroscopy. DLP-3 mainly consisted of Man, Rha, GlcA, Glc, Gal, and Ara with molar ratios of 2.32, 0.87, 1.21, 3.84, 1.00, and 1.05, respectively, with a molecular weight of 43.2 kDa. The main linkages of DLP-3 contained (1→4)-α-d-Glc, (1→4,6)-α-d-Glc, (1→6)-α-d-Gal, (1→2)-α-d-Man, (1→4)-α-d-Man, β-l-Ara-(1→, and α-l-Rha-(1→. DLP-3 exhibited a smooth surface, purely flake-like structure, and a triple helix conformation. Moreover, DLP-3 presented obvious antioxidant and antibacterial activities in a concentration-dependent manner. DLP-3 showed significant anticancer activities by inhibiting tumor cell proliferation. These findings provide a theoretical basis for the application of DLP-3 as a natural functional active substance in functional foods.

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“…de Wit (Leguminosae), and Peltophorum pterocarpum (DC.) K. Heyne (Leguminosae) could be explored as an effective alternative to commercial galactomannans for industrial purposes [20][21][22][23][24]. Galactomannans from Prosopis affinis Spreng (Leguminosae), seeds has shown molecular weight distribution and intrinsic viscosity similar to those of commercial gums [25].…”

Section: Galactomannansmentioning

confidence: 99%

Diosgenin and galactomannans, natural products in the pharmaceutical sciences

et al. 2021

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Background Diosgenin is an isospirostane derivative, which is a steroidal sapogenin and the product of acids or enzymes hydrolysis process of dioscin and protodioscin. Galactomannans are heteropolysaccharides composed of D-mannose and D-galactose, which are major sources of locust bean, guar, tara and fenugreek. Methods Literature survey was accomplished using multiple databases including PubMed, Science Direct, ISI web of knowledge and Google Scholar. Results Four major sources of seed galactomannans are locust bean (Ceratonia siliqua), guar (Cyamopsis tetragonoloba), tara (Caesalpinia spinosa Kuntze), and fenugreek (T.foenum-graecum). Diosgenin has effect on immune system, lipid system, inflammatory and reproductive systems, caner, metabolic process, blood system, blood glucose and calcium regulation. The most important pharmacological benefits of galactomannan are antidiabetic, antioxidant, anticancer, anticholinesterase, antiviral activities, and appropriate for dengue virus and gastric diseases. Conclusions Considering the importance of diosgenin and galactomannans, the obtained findings suggest potential of diosgenin and galactomannans as natural products in pharmaceutical industries.

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Optimization of extraction process and characterization of water-soluble polysaccharide (Galactomannan) from Algerian biomass; Citrullus colocynthis seeds

Cited by 19 publications

References 72 publications

Physicochemical Characterization and Antioxidant and Hypolipidaemic Activities of a Polysaccharide From the Fruit of Kadsura coccinea (Lem.) A. C. Smith

Physicochemical Characterization and Antioxidant and Hypolipidaemic Activities of a Polysaccharide From the Fruit of Kadsura coccinea (Lem.) A. C. Smith

Isolation of a New Polysaccharide from Dandelion Leaves and Evaluation of Its Antioxidant, Antibacterial, and Anticancer Activities

Diosgenin and galactomannans, natural products in the pharmaceutical sciences

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