Optimization of Extraction Process and Anti-Hemorrhoidal Activity of <i>Blumea lacera</i> (Burm.f.) DC. Leaves in Croton Oil-induced Hemorrhoid Model

Dubey, Tarkeshwar; Bhanukiran, Kancharla; Prasad, Shilpa; Hemalatha, S

doi:10.1177/09731296231170936

Cited by 3 publications

(1 citation statement)

References 30 publications

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“…Enhance Superoxide Dismutase (SOD) Activity and show antioxidant effect Reduce plasma exudation in anal tissue Tarkeshwar Dubey et al . [97]…”

Section: Leavesmentioning

confidence: 99%

Comprehensive Review on Hemorrhoids: From Epidemiology to Preclinical Assessment of Anti-Hemorrhoidal Agents

Bairagi,

Kulkarni,

Gunjal

et al. 2024

Int. J. Pharm. Sci. Drug Res.

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The review discusses the etiology, epidemiology, classification, risk factors, assessment, the role of biomarkers in the development of hemorrhoids, Operative, and Non-operative treatment options, postoperative complications of hemorrhoids, preclinical evaluation methods of anti-hemorrhoidal drugs, and different medicinal plants that show anti-hemorrhoidal activity. Hemorrhoids are characterized by the expansion and dislocation of typical anal cushions. One of the most significant discoveries regarding hemorrhoids is the atypical vascular channel dilatation and distortion, along with damage and modifications to the anal cavity's supporting connective tissue. Based on different factors, hemorrhoids are categorized in different classifications out of which Golingher’s classification is commonly used which divides the hemorrhoidal condition into 4 grades according to prolapse and development of hemorrhoids. Hemorrhoids are recognized as one of the main causes of morbidity which affects millions of people worldwide and also increases the economic overload on the health care system. Using current treatment options hemorrhoids are often treated conservatively using a variety of techniques, including fiber supplements, anti-inflammatory medications, lifestyle changes, and venotonic medicines. As well as using operative treatments like rubber band ligation, hemorrhoidectomy, and Injection sclerotherapy also various biomarkers play an important role in the progression of hemorrhoids like Matrix Metalloproteinase (MMP), inducible nitric oxide synthase (iNOS), and C-reactive protein (CRP), and Vascular endothelial growth factor (VEGF). These biomarkers can be a potential target for the development of new anti-hemorrhoidal agents.

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“…Enhance Superoxide Dismutase (SOD) Activity and show antioxidant effect Reduce plasma exudation in anal tissue Tarkeshwar Dubey et al . [97]…”

Section: Leavesmentioning

confidence: 99%

Comprehensive Review on Hemorrhoids: From Epidemiology to Preclinical Assessment of Anti-Hemorrhoidal Agents

Bairagi,

Kulkarni,

Gunjal

et al. 2024

Int. J. Pharm. Sci. Drug Res.

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Medicinal herbs from Western Himalayas for hemorrhoids treatment: A review correlating traditional knowledge with modern therapeutics

Dhiman,

Nadda,

Bhardwaj

2023

Pharmacological Research - Modern Chinese Medicine

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Synergistic therapeutic approach for hemorrhoids: integrating mesenchymal stem cells with diosmin-hesperidin to target tissue edema and inflammation

Kusumo,

Prayitno,

et al. 2024

Arch Med Sci

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IntroductionMesenchymal stem cells (MSCs) have promising regenerative properties in tissue repair and anti-inflammatory responses. This study aimed to investigate the effects of MSCs and their combination with micronized purified flavonoid fraction (MPFF) in a croton oil-induced hemorrhoids model on tissue edema, inflammation, and underlying molecular mechanisms.Material and methodsMSCs were isolated and characterized for their adherence, differentiation capacity, and immunophenotyping. Croton oil-induced hemorrhoid mouse models were established to assess tissue edema, inflammation, tumor necrosis factor (TNF-α) expression, transforming growth factor-β (TGF-β) expression, collagen ratio, and MMP-9 activity. The effects of MSCs and their combination with MPFF (diosmin-hesperidin) were evaluated through histological examinations, western blot analysis, and gelatin zymography.ResultsCharacterization confirmed the MSCs’ plastic adherence, osteogenic differentiation potential, and immunophenotype (positive for CD90 and CD29, negative for CD45 and CD31). Treatment with MSCs alone or in combination with MPFF significantly reduced tissue edema, inflammation, TNF-α expression, and MMP-9 activity. Additionally, MSCs increased TGF-β expression, and collagen type I/III ratio, and accelerated wound healing by resolving inflammation.ConclusionsThese findings suggest that MSCs play a crucial role in modulating TNF-α, TGF-β, collagen remodeling, and MMP-9 activity, highlighting their promising role in hemorrhoid treatment and wound healing processes. Further research is warranted to fully elucidate the intricate mechanisms and optimize MSC-based therapies for clinical applications in hemorrhoidal disease management.

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Optimization of Extraction Process and Anti-Hemorrhoidal Activity of Blumea lacera (Burm.f.) DC. Leaves in Croton Oil-induced Hemorrhoid Model

Cited by 3 publications

References 30 publications

Comprehensive Review on Hemorrhoids: From Epidemiology to Preclinical Assessment of Anti-Hemorrhoidal Agents

Comprehensive Review on Hemorrhoids: From Epidemiology to Preclinical Assessment of Anti-Hemorrhoidal Agents

Medicinal herbs from Western Himalayas for hemorrhoids treatment: A review correlating traditional knowledge with modern therapeutics

Synergistic therapeutic approach for hemorrhoids: integrating mesenchymal stem cells with diosmin-hesperidin to target tissue edema and inflammation

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