Optimization of FDM 3D printing process parameters to produce haemodialysis curcumin-loaded vascular grafts

Basile, Sara; Mathew, Essyrose; Conti, Bice; Dorati, Rossella; Lamprou, Dimitrios A.

doi:10.1007/s13346-021-01078-2

Cited by 4 publications

(3 citation statements)

References 34 publications

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“…Basile et al was manufacture TPU based vascular grafts with grade 80A with 0.25% curcumin to give antimicrobial properties. With the use of the 3D printing approach, it may be feasible to quickly produce a customized transplant straight from the patient's veins and arteries while preventing infection and maturation problems 113 . The primary cause of death in the elderly is cardiovascular disease (CVDs) 114 .…”

Section: Applicationsmentioning

confidence: 99%

“…With the use of the 3D printing approach, it may be feasible to quickly produce a customized transplant straight from the patient's veins and arteries while preventing infection and maturation problems. 113 The primary cause of death in the elderly is cardiovascular disease (CVDs). 114 The replacement of the blocked or constricted arteries, which is now the ideal vascular transplant combined with autograft transplantation, is a frequent medical surgery for the treatment of CVDs.…”

Section: Medical Sectormentioning

confidence: 99%

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Thermoplastic polyurethane for three‐dimensional printing applications: A review

Desai

Sonawane

2023

Polymers for Advanced Techs

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Additive manufacturing is an emerging technology with the advantage of less wastage, fast prototyping with customized designing suitable for a wide range of applications. Three‐dimensional (3D) printing is one of the types of additive manufacturing and various polymers are explored for 3D printing applications. Thermoplastic polyurethane (TPU) is a versatile material that has gained increasing attention in 3D printing applications due to its unique combination of mechanical, thermal, and chemical properties. This review paper provides an overview of the current state‐of‐the‐art in TPU‐based 3D printing, including its characteristics, processing techniques, and mainly its applications. Extensive studies are done in TPU with fused deposition modeling (FDM), multi‐jet fusion (MJF), and selective laser sintering (SLS). The elasticity and flexibility, layer adhesion, tensile strength, and support structure are the parameters that decide the suitability of FDM, SLS, and MJF for TPU 3D printing. The infill density, modification of processing parameters, use of sacrificial materials, addition of perforations or channels, varying the particle size, using a mixture of powders, and so forth. leads to develop the porous structure in the final product. In addition, we have studied blends of TPU with other polymers like acrylonitrile butadiene styrene (ABS) and polylactic acid (PLA), as well as fiber‐reinforced TPU composites for 3D printing applications.

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Section: Applicationsmentioning

confidence: 99%

Section: Medical Sectormentioning

confidence: 99%

Thermoplastic polyurethane for three‐dimensional printing applications: A review

Desai

Sonawane

2023

Polymers for Advanced Techs

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“…Generally, the isocyanates form the hard polyurethane segments, and diols or polyols groups form the soft polyurethane segments, providing tunable physical and mechanical properties depending upon the chain length. Several studies have demonstrated the application of TPU as vascular grafts [12], bone fixation screws [13], and drug delivery vehicles [14]. However, TPU has not yet been thoroughly explored as a biomaterial candidate for peripheral nerve tissue engineering applications.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of 3D printed anatomically equivalent thermoplastic polyurethane guide conduits in promoting the regeneration of critical-sized peripheral nerve defects

Zennifer,

Chellappan,

Chinnaswamy

et al. 2024

Biofabrication

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Three-dimensional (3D) printing is an emerging tool for creating patient-specific tissue constructs analogous to the native tissue microarchitecture. In this study, anatomically equivalent 3D nerve conduits were developed using thermoplastic polyurethane (TPU) by combining reverse engineering and material extrusion (i.e., fused deposition modeling) technique. Printing parameters were optimized to fabricate nerve-equivalent TPU constructs. The TPU constructs printed with different infill densities supported the adhesion, proliferation, and gene expression of neuronal cells. Subcutaneous implantation of the TPU constructs for three months in rats showed neovascularization with negligible local tissue inflammatory reactions and was classified as a non-irritant biomaterial as per ISO 10993-6. To perform in vivo efficacy studies, nerve conduits equivalent to rat’s sciatic nerve were fabricated and bridged in a 10 mm sciatic nerve transection model. After four months of implantation, the sensorimotor function and histological assessments revealed that the 3D printed TPU conduits promoted the regeneration in critical-sized peripheral nerve defects equivalent to autografts. This study proved that TPU-based 3D printed nerve guidance conduits can be created to replicate the complicated features of natural nerves that can promote the regeneration of peripheral nerve defects and also show the potential to be extended to several other tissues for regenerative medicine applications.

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Clinical situations for which 3D Printing is considered an appropriate representation or extension of data contained in a medical imaging examination: vascular conditions

Lee,

Chadalavada,

Ghodadra

et al. 2023

3D Print Med

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Background Medical three-dimensional (3D) printing has demonstrated utility and value in anatomic models for vascular conditions. A writing group composed of the Radiological Society of North America (RSNA) Special Interest Group on 3D Printing (3DPSIG) provides appropriateness recommendations for vascular 3D printing indications. Methods A structured literature search was conducted to identify all relevant articles using 3D printing technology associated with vascular indications. Each study was vetted by the authors and strength of evidence was assessed according to published appropriateness ratings. Results Evidence-based recommendations for when 3D printing is appropriate are provided for the following areas: aneurysm, dissection, extremity vascular disease, other arterial diseases, acute venous thromboembolic disease, venous disorders, lymphedema, congenital vascular malformations, vascular trauma, vascular tumors, visceral vasculature for surgical planning, dialysis access, vascular research/development and modeling, and other vasculopathy. Recommendations are provided in accordance with strength of evidence of publications corresponding to each vascular condition combined with expert opinion from members of the 3DPSIG. Conclusion This consensus appropriateness ratings document, created by the members of the 3DPSIG, provides an updated reference for clinical standards of 3D printing for the care of patients with vascular conditions.

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Optimization of FDM 3D printing process parameters to produce haemodialysis curcumin-loaded vascular grafts

Cited by 4 publications

References 34 publications

Thermoplastic polyurethane for three‐dimensional printing applications: A review

Thermoplastic polyurethane for three‐dimensional printing applications: A review

Efficacy of 3D printed anatomically equivalent thermoplastic polyurethane guide conduits in promoting the regeneration of critical-sized peripheral nerve defects

Clinical situations for which 3D Printing is considered an appropriate representation or extension of data contained in a medical imaging examination: vascular conditions

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