Anais Do I Simpósio Internacional De Imunobiológicos: Os Atuais Desafios Para a Construção De Embiente Favorável À Inovação E A 2013
DOI: 10.35259/isi.sact.2013_27331
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Optimization of high performance liquid chromatography by size exclusion and reversed phase for homogeneity analysis of recombinant human erythropoietin

Abstract: ObjectivesAmong the chromatographic methods advocated by the European Pharmacopoeia (E.P.)for the analysis of homogeneity of Recombinant Human Erythropoietin (rhEPO) stands the High Performance Liquid Chromatography by Size Exclusion (SEC-HPLC) and High Performance Liquid Chromatography by Reversed Phase (RP-HPLC). The aim of this study was to standardize and optimize the chromatographic methods in order to determine the purity, the presence of aggregates and the degradation products of rhEPO. MethodsIn accord… Show more

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