Optimization of Inversion Time for Postmortem Fluid-attenuated Inversion Recovery (FLAIR) MR Imaging at 1.5T: Temperature-based Suppression of Cerebrospinal Fluid

Abe, Kazuyuki; Kobayashi, Tomoya; Shiotani, Seiji; Saito, Hajime; Kaga, Kazunori; Tashiro, Kazuya; Someya, Satoka; Hayakawa, Hideyuki; Homma, Kazuhiro

doi:10.2463/mrms.2014-0086

Cited by 10 publications

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References 30 publications

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“…Within a small temperature range, the T 1 value depends linearly on the temperature in fat and water. 14 , 15 , 37 – 41 The T 2 value decreases with a declining temperature in fat tissue and aqueous solutions; 37 , 40 , 41 however, the temperature dependence of the T 2 value can be masked by other factors in tissue. 37 …”

Section: Discussionmentioning

confidence: 99%

Hepatic Relaxation Times from Postmortem MR Imaging of Adult Humans

et al. 2016

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Purpose:To measure T1 and T2 values of hepatic postmortem magnetic resonance (PMMR) imaging.Materials and Methods:We performed hepatic PMMR imaging of 22 deceased adults (16 men, 6 women; mean age, 56.3 years) whose deaths were for reasons other than liver injury or disease at a mean of 27.7 hours after death. Before imaging, the bodies were kept in cold storage at 4°C (mean rectal temperature, 17.6°C). We measured T1 and T2 values in the liver at two sites (the anterior segment of the right lobe and the lateral segment of the left lobe). We also investigated the influence of the body temperature and postmortem interval on T1 and T2 values.Results:In the anterior segment of the right lobe and the lateral segment of the left lobe, T1 values of PMMR imaging were 524 ± 112 ms and 472 ± 104 ms (mean ± standard deviation), respectively; while T2 values were 42 ± 6 ms and 43 ± 8 ms, respectively. T1 and T2 values did not differ significantly between the two sites (P ≧ 0.05). Regarding temperature, the T2 values of hepatic PMMR imaging were linearly correlated with the body temperature, but the T1 values were not. The T1 and T2 values of the two sites in the liver did not correlate with the postmortem interval.Conclusion:Reduction in body temperature after death is considered to induce T1 and T2 value changes in the liver on PMMR imaging.

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Section: Discussionmentioning

confidence: 99%

Hepatic Relaxation Times from Postmortem MR Imaging of Adult Humans

et al. 2016

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“…PW is treated water with a reverse osmosis membrane to remove most of the organic matter and ion components. Moreover, it is known that suppression of CSF is insufficient in the FLAIR image in postmortem MRI examinations . This is probably because the T1 value changes due to the fact that the postmortem temperature is lower than the biological temperature.…”

Section: Introductionmentioning

confidence: 99%

Cerebrospinal fluid T1 value phantom reproduction at scan room temperature

Yamashiro

Kobayashi

Saito

2019

J Applied Clin Med Phys

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The T1 value of pure water, which is often used as a phantom to simulate cerebrospinal fluid, is significantly different from that of in‐vivo cerebrospinal fluid. The purpose of this study was to develop a phantom with a T1 value equivalent to that of in‐vivo cerebrospinal fluid under examination room temperature (23°C–25°C). In this study, 1.5 and 3.0 T magnetic resonance imaging scanners were used. We examined the signal intensity change in relation to pure water temperature, the T1 values of acetone‐diluted solutions (0–100 v/v%, in 10 steps), and the correlation coefficients obtained from volunteers and the prepared phantoms. The T1 value was close to the value reported in the literature for cerebrospinal fluid when the acetone‐diluted solution was 70 v/v% or higher at scan room temperature. The value at that time was 3532.81–4704.57 ms at 1.5 T and it ranged from 4052.41 to 5701.61 ms at 3.0 T. The highest correlation with the values obtained from the volunteers was r = 0.993 with pure acetone at 1.5 T and r = 0.991 with acetone 90 v/v% at 3.0 T. The relative error of the best phantom‐volunteer match was 32.61 (%) ± 6.71 at 1.5 T and 46.67 (%) ± 4.31 at 3.0 T. The T1 value measured by the null point method did not detect a significant difference between in vivo CSF and acetone 100 v/v% at 1.5 T and acetone 90 v/v% at 3.0 T. The T1 value of cerebrospinal fluid in the living body at scan room temperature was reproduced with acetone. The optimum concentration of acetone for cerebrospinal‐fluid reproduction was pure acetone at 1.5 T and 90 v/v% at 3.0 T.

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