Optimization of Iontophoretic Parameters for the Transdermal Delivery of Methotrexate

Vemulapalli,; Ak, Banga; Pm, Friden

doi:10.1080/10717540802035145

Cited by 22 publications

(8 citation statements)

References 16 publications

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“…Thus, faint electric stimulus (ES) is driving force for transdermal migration of ionic substances by IP. IP was generally considered to be effective only for charged amphiphilic small molecules such as methotrexate, dexamethasone, buspirone, and diclofenac (2)(3)(4)(5). However, in vivo iontophoretic transdermal delivery of hydrophilic macromolecules including cationic liposomes, siRNA, and oligonucleotides, was recently successfully achieved (6 -10).…”

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confidence: 99%

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Electric Stimulus Opens Intercellular Spaces in Skin

Hama

Kimura

Mikami

et al. 2014

Journal of Biological Chemistry

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Background: Although skin is a tight barrier, transdermal liposome delivery is achievable by faint electric stimulus (ES). Results: ES caused rigid nanoparticle penetration into the epidermis, and induced connexin 43 phosphorylation, actin fiber depolymerization and Ca 2ϩ -influx. Conclusion: Our data indicate that ES opens epidermis intercellular spaces via intracellular signaling activation. Significance: Skin barrier permeability could be controlled by ES via changes in cutaneous physiological properties.

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confidence: 99%

“…Iontophoresis (IP) 3 is a noninvasive technology that physically enhances transdermal penetration of ionic medicines using faint electricity (1). Thus, faint electric stimulus (ES) is driving force for transdermal migration of ionic substances by IP.…”

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confidence: 99%

Electric Stimulus Opens Intercellular Spaces in Skin

Hama

Kimura

Mikami

et al. 2014

Journal of Biological Chemistry

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“…Several researchers have reported in the literature that, for small molecules, as the concentration of the drug goes up, amount of drug delivered also increases. While peptides and proteins might be more complex compared with small molecules, they have also been shown to typically follow a similar trend (21). For example, Langkjaer et al (22) have indicated that the amount of insulin delivered at concentrations of 1-3 mM were 30-fold higher than the amount delivered at 0.1 mM.…”

Section: Formulation Considerations-donor Concentration and Formulatimentioning

confidence: 97%

Transdermal Delivery of Proteins

2011

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Abstract. Transdermal delivery of peptides and proteins avoids the disadvantages associated with the invasive parenteral route of administration and other alternative routes such as the pulmonary and nasal routes. Since proteins have a large size and are hydrophilic in nature, they cannot permeate passively across the skin due to the stratum corneum which allows the transport of only small lipophilic drug molecules. Enhancement techniques such as chemical enhancers, iontophoresis, microneedles, electroporation, sonophoresis, thermal ablation, laser ablation, radiofrequency ablation and noninvasive jet injectors aid in the delivery of proteins by overcoming the skin barrier in different ways. In this review, these enhancement techniques that can enable the transdermal delivery of proteins are discussed, including a discussion of mechanisms, sterility requirements, and commercial development of products. Combination of enhancement techniques may result in a synergistic effect allowing increased protein delivery and these are also discussed.

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“…Methotrexate being hydrosoluble carries a negative charge at physiological pH and is suitable for iontophoretic drug delivery . This study was undertaken to evaluate and compare the efficacy of topical methotrexate by iontophoresis technique with clobetasol propionate 0.05% ointment in the treatment of palmar psoriasis.…”

Section: Introductionmentioning

confidence: 99%

Iontophoretic delivery of methotrexate in the treatment of palmar psoriasis: A randomised controlled study

2020

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Background/Objectives: Palmoplantar psoriasis is a localised variant of psoriasis. Topical therapy is the preferred treatment modality, but in severe and recalcitrant cases, systemic drugs like methotrexate are prescribed, with potential for significant adverse effects. Iontophoresis is gaining popularity in enhancing the transdermal delivery of drugs in ionic state. This study was undertaken to evaluate and compare the efficacy of topical methotrexate by iontophoresis technique with clobetasol propionate 0.05% ointment in the treatment of palmar psoriasis.Methods: This was a prospective randomised controlled study conducted on patients with palmar psoriasis. Group 1 patients (n = 31) were treated with once weekly iontophoretic delivery of methotrexate over 6 sittings, and group 2 patients (n = 31) were treated with clobetasol propionate 0.05% ointment, twice daily for 6 weeks. Severity of palmar psoriasis was assessed by modified Palmoplantar Pustular Psoriasis Area and Severity Index (m-PPPASI), and treatment was considered as satisfactory when there was >50% improvement.Results: Sixty two patients were recruited, of which 50 completed the study. Eight out of 25 (32%) patients in group 1 and 12 out of 25 (48%) patients in group 2 showed satisfactory improvement at the end of 6 weeks. However, this difference was statistically not significant (P = 0.25). Burn injury was noted in 12 (48%) group 1 patients with no adverse effects in group 2.Conclusion: Iontophoretic delivery of methotrexate is a promising therapeutic modality, the efficacy of which is comparable to that of clobetasol propionate ointment in the treatment of palmar psoriasis.

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Optimization of Iontophoretic Parameters for the Transdermal Delivery of Methotrexate

Cited by 22 publications

References 16 publications

Electric Stimulus Opens Intercellular Spaces in Skin

Electric Stimulus Opens Intercellular Spaces in Skin

Transdermal Delivery of Proteins

Iontophoretic delivery of methotrexate in the treatment of palmar psoriasis: A randomised controlled study

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