Optimization of Ketoprofen-loaded Chitosan Nanoparticle Ultrasonication Process

Sugita, Purwantiningsih; Ambarsari, Laksmi; Lidiniyah,

doi:10.1016/j.proche.2015.12.007

Cited by 10 publications

(8 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[3][4][5] Penelitian sebelumnya telah menunjukkan bahwa teknik ultrasonikasi mampu digunakan untuk menyintesis ikatan silang kitosan-tripolifosfat sebagai pembawa DNF dengan homogenisasi menggunakan ultrasonikator. 6 Penelitian lain membuktikan bahwa teknik stirring menggunakan magnetic stirrer dapat menyintesis ikatan silang kalsium alginat dengan berbagai variasi konsentrasi alginat. 7 [6][7][8][9][10] Efek mekanik dapat dihasilkan melalui perputaran, getaran magnetic stirrer, dan pergerakan gelembung udara aerasi (teknik low energy), maupun dari getaran gelombang ultrasonik (utrasonikator/ teknik high energy).…”

Section: Pendahuluanunclassified

Perbandingan Teknik Aerasi dan Ultrasonikasi Gelasi Ionik Nanopartikel Deksametason Natrium Fosfat

Nugroho

Wardhani

Suparmi

2020

jki

View full text Add to dashboard Cite

Alginate, a biocompatible and biodegradable natural polymer, has been widely used as a drug molecular carrier using ionic gelation methods (crosslinking). One of the factors that must be taken into account in its preparation is the mechanical effect. The purpose of this study was to explain the preparation process and the characteristics of the calcium alginate crosslinkers as dexamethasone sodium phosphate carriers with low energy and high energy techniques. Nanosuspension is made in six formulas using 3 techniques: low energy (aeration), high energy (ultrasonication), low and high energy (aeration and ultrasonication) with a fixed concentration of dexamethasone sodium phosphate and sodium alginate, that is 0,2% and 0,1%, with 0,02% and 0,2% of calcium chloride. Determination of particle size, zeta potential, and morphology of nanoparticles using Particle Size Analyzer (PSA) and Scanning Electron Microscope (SEM), Transmission Electron Microscope (TEM). Determination of encapsulation efficiency using UV/Vis spectrophotometer and statistical analysis using MANOVA test. Synthesis of nanosuspension using a combination of low and high energy (aeration and ultrasonication) results in the most optimal characteristics with particle size value of 352.90 ± 6.10 nm, homogenized polydispersity index (0,52 ± 0,04), optimal potential zeta -44,40 ± 0,4 mV, the encapsulation efficiency of 49,5 - 74,8% and spherical particle shape. It can be concluded that the preparation using a combination of low and high energy is the most optimal preparation result.

show abstract

Section: Pendahuluanunclassified

Perbandingan Teknik Aerasi dan Ultrasonikasi Gelasi Ionik Nanopartikel Deksametason Natrium Fosfat

Nugroho

Wardhani

Suparmi

2020

jki

View full text Add to dashboard Cite

show abstract

“…Ketoprofen-loaded CS was made by modifying cytoprotective nonionic block copolymer poloxamer 188 (a non-ionic linear copolymer composed of two hydrophilic side chains and a hydrophobic center core) and also varying the time and amplitude of ultrasonication [50].…”

Section: Biopolymers and Biopolymer Nanocompositesmentioning

confidence: 99%

“…The functional amino groups on CS macromolecules helped the polymer to participate in chemical reactions, which led to derivatives with improved characteristics such as mucoadhesion, high drug loading, and the ability to transfer genes. Some other chemical modifications have gained interest for the preparation of a photopolymerizable CS derivative or improvements to CS solubility in water [50].…”

Section: Polymer Hydrogels and Nanogelsmentioning

confidence: 99%

Polymers and Polymer Nanocomposites for Cancer Therapy

Feldman

2019

Applied Sciences

View full text Add to dashboard Cite

Synthetic polymers, biopolymers, and their nanocomposites are being studied, and some of them are already used in different medical areas. Among the synthetic ones that can be mentioned are polyolefins, fluorinated polymers, polyesters, silicones, and others. Biopolymers such as polysaccharides (chitosan, hyaluronic acid, starch, cellulose, alginates) and proteins (silk, fibroin) have also become widely used and investigated for applications in medicine. Besides synthetic polymers and biopolymers, their nanocomposites, which are hybrids formed by a macromolecular matrix and a nanofiller (mineral or organic), have attracted great attention in the last decades in medicine and in other fields due to their outstanding properties. This review covers studies done recently using the polymers, biopolymers, nanocomposites, polymer micelles, nanomicelles, polymer hydrogels, nanogels, polymersomes, and liposomes used in medicine as drugs or drug carriers for cancer therapy and underlines their responses to internal and external stimuli able to make them more active and efficient. They are able to replace conventional cancer drug carriers, with better results. Appl. Sci. 2019, 9, 3899 2 of 24 nanocomposites offer numerous opportunities in diverse applications, including nanocarriers, tissue engineering, antimicrobials, sensors, etc. These new groups of materials have gained significant research interest due to their novel properties, which are gained through the addition of nanofillers. Polymer nanocomposites have significant potential in disease theranostics, and nanotechnology brings great promise in cancer drug carriers [4].Chemotherapy implies the use of drugs and, besides the drugs, carriers. Common products used as carriers include synthetic polymers, biopolymers, and polymer nanocomposites.Some of the most useful drugs for chemotherapy are toxic chemicals able to inhibit the proliferation of cancer cells. The use of chemotherapeutic drugs has been in part hindered by their poor solubility in water, their short biological half-life, their lack of targeting ability, and the development of multidrug resistance [5]. In the last decades, nanoparticles have shown significant promise as an oncology treatment modality. Responsive polymers represent a promising class of nanoparticles that can trigger delivery through the exploitation of a specific stimuli. Response to a stimulus is one of the most basic processes found in living systems. A tutorial review highlighted the recent developments in polymer-based approaches to internally responsive nanoparticles for oncology [6].One important goal of medicine is to develop carriers that can selectively deliver anticancer drugs to tumor cells with no or minimal side effects in healthy cells [7,8].Polymers and their nanocomposites in different forms, such as micelles, hydrogels, polymersomes, and liposomes, have important potential in cancer diagnosis and treatment.Nanocomposites are popular in many areas due to properties such as their unique design capacity, eco-friendly nature, ...

show abstract

“…CSNPs were synthesized by the enhanced method of ionic gelation, which was developed by Calvo [5] and then advanced using the ultrasonicator [8,13,32] . The AMD-β-CD solution was added to the CS solution at a concentration of 4 mg/ml (w/v) and filtered through a 0.45 μm syringe filter.…”

Section: Preparation Of the Amd-loaded Csnpsmentioning

confidence: 99%

“…Tang et al [8] , Saha et al [9] , Rafeeq et al [10] and Azelea et al [11] synthesized CSNPs by ionic gelation and then the samples were treated by sonication. After 2014; Gouda et al [12] , Sugita et al [13] , Xu et al [14] and Chouljenko et al [15] used only a sonicator device to produce CSNPs. These results showed that sonication is helpful in many ways for production of CSNPs.…”

mentioning

confidence: 99%

Synthesis of Chitosan Nanoparticles for Controlled Release of Amiodarone

Büyük¹,

Arayıcı²,

Derman³

et al. 2020

ijps

View full text Add to dashboard Cite

Buyuk et al.: Amiodarone-loaded Chitosan NanoparticlesThis work is based on a natural polymer chitosan used in a nanoparticulate drug delivery system for the controlled release of amiodarone along with β-cyclodextrin. Amiodarone-loaded chitosan nanoparticles were prepared using the ionic gelation method aided by sonication. Amiodarone loading on chitosan nanoparticles was done under optimum conditions. For particle characterization; zeta-sizer, UV/Vis, Fourier-transform infrared spectroscopy, X-ray powder diffraction, differential scanning calorimeter and scanning electron microscope techniques were used. In vitro drug release studies of amiodaroneloaded chitosan nanoparticles were performed using the dialysis diffusion technique. Drug loading and release values were determined using UV/Vis spectroscopy. Amiodarone encapsulated in nanoparticles was completely released at the end of 14 days. About 38 % was released at the end of day 1, 44% released at the end of day 3, 50 % released at the end of day 5 followed slow release. Amiodarone-loaded chitosan nanoparticles could serve as a model for controlled delivery of many antiarrhythmic drugs.

show abstract

Optimization of Ketoprofen-loaded Chitosan Nanoparticle Ultrasonication Process

Cited by 10 publications

References 16 publications

Perbandingan Teknik Aerasi dan Ultrasonikasi Gelasi Ionik Nanopartikel Deksametason Natrium Fosfat

Perbandingan Teknik Aerasi dan Ultrasonikasi Gelasi Ionik Nanopartikel Deksametason Natrium Fosfat

Polymers and Polymer Nanocomposites for Cancer Therapy

Synthesis of Chitosan Nanoparticles for Controlled Release of Amiodarone

Contact Info

Product

Resources

About