With the increase of low-altitude flight tasks, the importance of research on low-altitude flight safety and efficient operation has gradually become prominent. Therefore, it is necessary to try to establish a low-altitude airspace flight path pre-planning method based on 4D trajectory prediction, which can effectively support the above research. In order to improve the integrity, accuracy and reliability of the long-range trajectory prediction results of large fixed wing UAV (LFW UAV), based on the standard neural network as the basic concept to form a fusion model of improved convolutional neural network and bidirectional gated recurrent neural network. At the same time, the flight trajectory fitting preprocessing is added to build the completed multilayer cyclic convolutional improvement model (MCCI). The experimental results show that the MCCI model has obvious advantages in terms of prediction accuracy, deviation range and predictable duration when dealing with the LFW UAV 4D trajectory prediction problem, and better reflects the characteristics of 3D position and spatiotemporal elements. The comparative analysis shows that the error values of the MCCI model are smaller than those of the comparison prediction models in any dimension, and the prediction results have better fit and model performance.