Optimization of Solvent Gradients for Chromatographic Separations

Abstract

Due to increasing purity requirements, temperature sensitivity and complexity of feed mixtures, chromatographic separations are more and more applied to purify value added products. Frequently, gradient chromatography is used to reduce the duration of batch separations of mixtures with very different retention times of the components. In this case the retention times of the slowly migrating components are reduced by increasing the elution strength of the eluant.