Optimization of spray drying process for formulation of solid dispersion containing polypeptide-k powder through quality by design approach

Kaur, Puneet; Singh, Sachin Kumar; Garg, Varun; Gulati, Monica; Vaidya, Yogyata

doi:10.1016/j.powtec.2015.06.034

Cited by 59 publications

(14 citation statements)

References 34 publications

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“…A funnel was clamped with its tip 7 cm above the surface. The tangent of the angle of repose was the ratio of the height of the heap of powder to the semi-diameter of the base of the heap of powder (Kaur et al, 2015).…”

Section: Angle Of Reposeimentioning

confidence: 99%

Microencapsulation of plum (Prunus salicina Lindl.) phenolics by spray drying technology and storage stability

Tang

Chen

et al. 2017

Food Sci. Technol

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Section: Angle Of Reposeimentioning

confidence: 99%

Microencapsulation of plum (Prunus salicina Lindl.) phenolics by spray drying technology and storage stability

Tang

Chen

et al. 2017

Food Sci. Technol

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“…These droplets are going for evaporation process and produce SDs commercially available spray dryer such as incivek and intelence which is utilized for production of SDs. Kaur et al [41] had presented the formulation of SD containing polypeptide-k to enhance its aqueous solubility using trehalose and Tween-80 they had concluded that the optimized batch of formulation had exhibited higher solubility in water as well as various aqueous buffers as compared to pure polypeptide-k. Ramesh et al [42] had enhanced the dissolution rate of Etravirine by converting it from crystalline to amorphous form by spray drying method. They had used various polymers such as Solupus and Povidone which covert it into highly soluble amorphous form.…”

Section: Spray Dryingmentioning

confidence: 99%

Recent Approaches of Solid Dispersion: A New Concept Toward Oral Bioavailability Sabitri Bindhani* , Snehamayee Mohapatra

Bindhani

Mohapatra

2018

Asian J Pharm Clin Res

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Solid dispersion (SD) has been a major advanced technology in overcoming dissolution and bioavailability problem of poorly soluble compounds. Formulation of SD in water-soluble carrier has becoming more researched over the past four decades for solubility and relative bioavailability enhancement. By reduction of the size of the drug particle to the minimum level which will enhance drug wettability and ultimately bioavailability will be definitely improved. This review article elaborates recent advanced technology and characterization of SDs and also discusses the problems and their solution for the development of better formulations.

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“…The solutions were then filtered (cut-off 0.2 µm, Ministart SRP 25, Sartorius) and analyzed. The studies were performed in triplicate and mean data were recorded [30]. "…”

Section: Micromeritic Characterization Of Powdersmentioning

confidence: 99%

“…Powder X-ray diffraction (PXRD) analysis "PXRD patterns were recorded as per Kaur et al [30]. In brief, CRM-R, CRM-NS (SD), and CRM-NS (SD) were recorded using an X-ray diffractometer (Bruker Axs, D8 Advance) with Cu line as the source of radiation.…”

Section: Micromeritic Characterization Of Powdersmentioning

confidence: 99%

Formulation of Curcumin Nanosuspension Using Box-Behnken Design and Study of Impact of Drying Techniques on Its Powder Characteristics

Kaur

Bawa

Rajesh

et al. 2017

Asian J Pharm Clin Res

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Objective: The objective of this study was to formulate curcumin nanosuspension (NS) using Box-Behnken design (BBD) and solvent-antisolvent technique to overcome the challenges related to its poor dissolution rate.Methods: Sodium lauryl sulfate (SLS) and poly vinyl pyrrolidone K-60 (PVPK-60) have been used as a surfactant and polymer, respectively, to stabilize the NS. Ethanol was used as solvent to dissolve curcumin and water was used as antisolvent. The study revealed that SLS to curcumin ratio, PVPK-60 to curcumin ratio, solvent to antisolvent ratio and speed of mixing were the critical parameters that affected particle size and zeta potential of the formulation. Hence, based on Box-BBD, 25 formulations were prepared by varying these critical parameters. The optimized batch of CRM NS was further solidified using spray drying as well as rotary evaporation techniques to have a better insight for selection of solidification process in terms of retention of particle size, charge, flow, dissolution, and stability.Results: About 39.47 folds decrease in particle size of raw CRM was observed after conversion into NS. Further, about 53.57 and 45.45 folds decrease in particle size was observed after spray drying and rotary evaporation. Both the dried nanoparticles have shown comparatively higher solubility, powder flow, and dissolution rate as that of raw CRM. Powder X-ray diffraction study revealed the formation of amorphous nanoparticles. Accelerated stability study revealed that nanoparticles dried by spray drying were able to retain the properties such as particle size, flow, and dissolution rate as compared to rotary evaporated powders. Conclusion:It can be concluded that spray drying technique could offer many advantages while loading CRM nanoparticles into tablets for their oral administration.

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Optimization of spray drying process for formulation of solid dispersion containing polypeptide-k powder through quality by design approach

Cited by 59 publications

References 34 publications

Microencapsulation of plum (Prunus salicina Lindl.) phenolics by spray drying technology and storage stability

Microencapsulation of plum (Prunus salicina Lindl.) phenolics by spray drying technology and storage stability

Recent Approaches of Solid Dispersion: A New Concept Toward Oral Bioavailability Sabitri Bindhani* , Snehamayee Mohapatra

Formulation of Curcumin Nanosuspension Using Box-Behnken Design and Study of Impact of Drying Techniques on Its Powder Characteristics

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