Optimization of the calculation time in simulation using the GATE/GEANT4 Monte Carlo of radiotherapy treatment plans for small fields

Abstract

Radiation therapy is one of the most widely used methods of treating cancer. One of the therapeutic gains of this method is to save in terms of calculation time during treatment planning, the variance reduction method is one of the most used to reduce the calculation time except that there are other alternatives to be able to optimize as much as possible, hence the interest of this study. In this work, we compared by Monte-Carlo simulation the flattened and unflattened 6 MV photon beams of the VARIAN Clinac 2100 linear accelerator. All the elements of the accelerator were simulated and allowed us to reproduce very close to reality. The doses obtained by simulation were taken in a tank of water under reference conditions, source to surface distance (SSD) of 100 cm, the arm at 0 ° and for a field variation of 2 x 2 cm2, 3 x 3 cm2, 4 x 4 cm2, 5 x 5 cm2, 10 x 10 cm2, 20 x 20 cm2, 30 x 30 cm2, 40 x 40 cm2. For each field, we calculated using a beam with a flattening filter (FF) and another beam with flattening filter-free (FFF). The calculation time of all these simulations was recorded. The results showed that the shape of the dose profiles changes according to the FF and FFF mode with a very interesting change for fields greater than 5 x 5 cm2 and almost similar profiles for the fields 2 x 2 cm2, 3 x 3 cm2, 4 x 4 cm2, 5 x 5cm2. The region between 80% and 100% of doses for beams with FF contributes to dose uniformity while for FFF fields gives the appearance of symmetry of dose distribution for all fields combined. On the depth dose curves (PDD) the dose at the entry into FFF mode was greater than that of FF mode leading to an increase in the influence of photons, the latter thus important on the increase in dose rate. The computation time in FF mode is higher by a proportion factor of 0.85 to 7.36 compared to the FFF mode respectively by going from the field 2 x 2 cm2 to 40 x 40 cm2. This comparison leads to being able to neglect the flattening filter for fields smaller than 5 x 5 cm2 since it has no impact on the processing field but has a great impact on the calculation time and to have a mode without this filter for fields smaller than 5 x 5 cm2 leads to an optimization of the computation time of 1.35 times compared to the FF mode.