Optimization of the stability constants of the ternary system of diclofenac/famotidine/β-cyclodextrin by nonlinear least-squares method using theoretical equations

Comparative study on the effects of the inclusion complexes of non-steroidal anti-inflammatory drugs with 2-hydroxypropyl-β-cyclodextrins on dissociation rates and supersaturation

“…To prepare the API/HP-β-CD mixture, 54,55 a solution with a mass corresponding to the final 2-3 mmol kg −1 API was dissolved in 80 mL ethanol (Milli-Q water for LXP-Na). This was then mixed with aqueous solutions in the relative triple, double, equivalent, a half, and one-third molality of HP-β-CD, preparing the APIs/HP-β-CD mixtures with molar ratios of 1 : 3 1 : 2, 1 : 1, 2 : 1, and 3 : 1, respectively.…”

How Does the Powder Mixture of Ibuprofen and Caffeine Attenuate the Solubility of Ibuprofen? Comparative Study for the Xanthine Derivatives to Recognize Their Intermolecular Interactions Using Fourier-Transform Infrared (FTIR) Spectra, Differential Scanning Calorimetry (DSC), and X-ray Powder Diffractometry (XRPD)

“…Given that spectrometric data often exhibit co-occurrence (dependence) in individual signals due to intertwined absorptions (or emissions) from structural components, the SVD method efficiently accounts for this co-occurrence between similarity patterns. 59 SVD has been successfully applied to derivative spectra of various spectroscopic techniques, such as FTIR derivative spectra, 58 UV−visible spectra, 59,60 far-UV circular dichroism (CD) spectra, 61 powder X-ray diffractograms, [54][55][56]62 electron spin resonance (ESR), 63 fluorescence spectra, 64,65 and curves, 56 to quantify specific contributions of experimental conditions.…”

Using singular value decomposition to analyze drug/β-cyclodextrin mixtures: insights from X-ray powder diffraction patterns

“…24 Tsunoda et al have discussed the individual intermolecular interactions of these basic drugs with acidic drugs. 25 Therefore, indomethacin and diclofenac were selected as low-solubility acidic drugs with the aim of clarifying the difference in the effects of FAM and CIM.…”