Optimized-dose lidocaine-loaded sulfobutyl ether β-cyclodextrin/hyaluronic acid hydrogels to improve physical, chemical, and pharmacological evaluation for local anesthetics and drug delivery systems

Zhou, Liyuan; Wang, Yanhong; Pan, Rongrong; Wan, Zhan-Hai; Zhang, Mengjie; Liu, Yatao

doi:10.1007/s10853-022-07072-4

Cited by 6 publications

(1 citation statement)

References 64 publications

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“…Lidocaine (LDC)-loaded sulfobutyl ether β-cyclodextrin (SCD)/hyaluronic acid (HA) hydrogels were prepared by Zhou et al. compared to free lidocaine, SCD/HA-LDC showed significantly prolonged analgesic effects and lower cytotoxicity (Zhou et al., 2022 ).…”

Section: Polymer-based Local Anesthetic Drug Delivery Systemmentioning

confidence: 99%

Advances in the use of local anesthetic extended-release systems in pain management

Chen,

Xu,

et al. 2023

Drug Delivery

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Pain management remains among the most common and largely unmet clinical problems today. Local anesthetics play an indispensable role in pain management. The main limitation of traditional local anesthetics is the limited duration of a single injection. To address this problem, catheters are often placed or combined with other drugs in clinical practice to increase the time that local anesthetics act. However, this method does not meet the needs of clinical analgesics. Therefore, many researchers have worked to develop local anesthetic extended-release types that can be administered in a single dose. In recent years, drug extended-release systems have emerged dramatically due to their long duration and efficacy, providing more possibilities for the application of local anesthetics. This paper summarizes the types of local anesthetic drug delivery systems and their clinical applications, discusses them in the context of relevant studies on local anesthetics, and provides a summary and outlook on the development of local anesthetic extended-release agents.

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Section: Polymer-based Local Anesthetic Drug Delivery Systemmentioning

confidence: 99%