Optimized flurbiprofen cationic liposomes <i>in situ</i> gelling system of thermosensitive polymers for ocular delivery

He, Ling; Xu, Hao; Nie, Song; Yang, Xinggang; Yin, Jian; Pan, Wei-San

doi:10.1002/app.33883

Cited by 8 publications

(2 citation statements)

References 63 publications

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“…Unfortunately, the preparation of liposomes is associated with disadvantages because of the instability, degradability and aggregation of the liposomes and with limitations in drug loading, particularly for hydrophilic drugs . One approach to overcome these disadvantages in enabling administration to the eye is dispersing the liposomes in polymeric formulations . One of the more recent investigations that used this strategy stabilised flurbiprofen‐containing cationic liposomes within a thermosensitive gel that formed in situ .…”

Section: Delivery Systemsmentioning

confidence: 99%

“…[48,[149][150][151] One approach to overcome these disadvantages in enabling administration to the eye is dispersing the liposomes in polymeric formulations. [49,50,77,127,152,153] One of the more recent investigations that used this strategy stabilised flurbiprofen-containing cationic liposomes within a thermosensitive gel that formed in situ. [132] This formulation enhanced the transcorneal penetration of the drug relative to cationic liposomes alone or eye drops.…”

Section: Liposomesmentioning

confidence: 99%

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Topical delivery of ocular therapeutics: carrier systems and physical methods

Souza

Dias

Pereira

et al. 2014

Journal of Pharmacy and Pharmacology

117

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Objective The basic concepts, major mechanisms, technological developments and advantages of the topical application of lipid-based systems (microemulsions, nanoemulsions, liposomes and solid lipid nanoparticles), polymeric systems (hydrogels, contact lenses, polymeric nanoparticles and dendrimers) and physical methods (iontophoresis and sonophoresis) will be reviewed. Key findings Although very convenient for patients, topical administration of conventional drug formulations for the treatment of eye diseases requires high drug doses, frequent administration and rarely provides high drug bioavailability. Thus, strategies to improve the efficacy of topical treatments have been extensively investigated. In general, the majority of the successful delivery systems are present on the ocular surface over an extended period of time, and these systems typically improve drug bioavailability in the anterior chamber whereas the physical methods facilitate drug penetration over a very short period of time through ocular barriers, such as the cornea and sclera. Summary Although in the early stages, the combination of these delivery systems with physical methods would appear to be a promising tool to decrease the dose and frequency of administration; thereby, patient compliance and treatment efficacy will be improved.

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Section: Delivery Systemsmentioning

confidence: 99%