Optimized preparation process for naringenin and evaluation of its antioxidant and α‐glucosidase inhibitory activities

Abstract

Diabetes mellitus (DM) is a common and frequently occurring disease that seriously endangers human health. As lifestyles have changed, DM has gradually developed into one of the most significant chronic diseases for mankind (Zhou, Lu, Liu, Pan, & Zhou, 2014). It is currently estimated that the number of diabetic patients in the world will increase from 240 to 642 million by 2040 (Reusch & Manson, 2017). In China, more than 100 million people will be suffering from tape 2 DM by the 2040s (Carracher, Marathe, & Close, 2018). Therefore, DM remains a hot topic for studies. The pathogenesis of DM is complex and has not yet been elucidated. Oxidative stress is closely related to the occurrence and development of diabetes and its complications: β-cells in the pancreas are oxidized by free radicals and lose the ability to secrete insulin, which increases the risk of DM (Zeng et al., 2019). α-Glucosidase is an important metabolic enzyme in the body that can hydrolyze carbohydrates into glucose. α-Glucosidase inhibitors can reduce and delay the production of

Phytochemical Profile, α-Glucosidase, and α-Amylase Inhibition Potential and Toxicity Evaluation of Extracts from Citrus aurantium (L) Peel, a Valuable By-Product from Northeastern Morocco

“…Here, we confirmed that naringenin has a higher affinity (ΔG = −7.2 kcal/mol) for interacting with α-glucosidase in its active site ( Figure S3 ). This result is consistent with prior research that suggested naringenin may have antidiabetic properties [ 45 , 46 , 47 ]. Naringenin, alongside naringin, both of which are abundant in the peel of Citrus species, shows high antidiabetic activity in type 2 diabetic rats induced by NA/STZ [ 17 ].…”

“…Here, we confirmed that naringenin has a higher affinity (ΔG = −7.2 kcal/mol) for interacting with α-glucosidase in its active site (Figure S3). This result is consistent with prior research that suggested naringenin may have antidiabetic properties [45][46][47]. Naringenin, alongside naringin, both of which are abundant in the peel of The potential antidiabetic efficacy of different extracts from the peel of C. aurantium was revealed in this study by examining their inhibitory effects on α-amylase and αglucosidase in vitro.…”

Seasonal Effects on Phenolic Contents and In Vitro Health-Promoting Bioactivities of Sacred Lotus (Nelumbo nucifera)

“…These results indicated that naringenin possessed neuroprotective and hypertensive inhibitory effects even though the in vitro enzyme inhibitory investigation suggested that naringenin was not a good inhibitor. Naringenin was also an effective inhibitor against α-glucosidase (IC 50 of 0.79 mM) comparing to acarbose, an anti-diabetic drug (IC 50 of 2.03 mM) [ 20 ]. Naringenin (25 mg/kg) could lower postprandial serum glucose levels in streptozotocin (STZ)-induced diabetic rats [ 21 ].…”

Flavonoids as dual-target inhibitors against α-glucosidase and α-amylase: a systematic review of in vitro studies

“…Overall, naringin (18) was recorded to exhibit strong inhibition against both enzymes in the majority of studies involved. 61,86,[94][95][96][97] However, in two studies reported by Kong et al 95 and Zhang et al, 86 this compound was reported to inhibit α-glucosidase not as well as acarbose in the same condition, as the IC50 values stood at 27.2 mM and 22.1 mM, respectively. Therefore, further evidence is needed to confirm the potency of this compound.…”

“…Naringenin (9) is the most well-studied flavanone with 16 studies employing this compound in their inhibition assay. 39,46,61,69,[77][78][79][80][81][82][83][84][85][86][87] Concerning the α-glucosidase inhibition, naringenin was recorded to exhibit stronger inhibitory activity than acarbose in the same condition in the majority of the reported results.…”