2023
DOI: 10.21203/rs.3.rs-2266128/v1
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Optimized screening of DNA methylation sites combined with gene expression analysis to identify diagnostic markers of colorectal cancer

Abstract: Background The prognosis of patients with colorectal cancer is related to early detection. However, commonly used screening markers lack sensitivity and specificity. In this study, we identified diagnostic methylation sites for colorectal cancer. Methods After screening the colorectal cancer methylation dataset, diagnostic sites were identified via survival analysis, difference analysis, and ridge regression dimensionality reduction. The correlation between the selected methylation sites and the estimation of … Show more

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