Optimizing cystoscopy and TURBT: enhanced imaging and artificial intelligence

Shkolyar, Eugene; Zhou, Steve R.; Carlson, Camella J.; Chang, Shuang; Laurie, Mark A.; Xing, Lei; Bowden, Audrey K.; Liao, Joseph C.

doi:10.1038/s41585-024-00904-9

Nat Rev Urol

2024

DOI: 10.1038/s41585-024-00904-9

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Optimizing cystoscopy and TURBT: enhanced imaging and artificial intelligence

Eugene Shkolyar,

Steve R. Zhou,

Camella J. Carlson

et al.

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2024

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Cited by 2 publications

References 90 publications

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Low-cost and label-free blue light cystoscopy through digital staining of white light cystoscopy videos

Chang,

Wintergerst,

Carlson

et al. 2024

Commun Med

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Background Bladder cancer is the 10 th most common malignancy and carries the highest treatment cost among all cancers. The elevated cost stems from its high recurrence rate, which necessitates frequent surveillance. White light cystoscopy (WLC), the standard of care surveillance tool to examine the bladder for lesions, has limited sensitivity for early-stage bladder cancer. Blue light cystoscopy (BLC) utilizes a fluorescent dye to induce contrast in cancerous regions, improving the sensitivity of detection by 43%. Nevertheless, the added equipment cost and lengthy dwell time of the dye limits the availability of BLC. Methods Here, we report the first demonstration of digital staining as a promising strategy to convert WLC images collected with standard-of-care clinical equipment into accurate BLC-like images, providing enhanced sensitivity for WLC without the associated labor or equipment cost. Results By introducing key pre-processing steps to circumvent color and brightness variations in clinical datasets needed for successful model performance, the results achieve a staining accuracy of 80.58% and show excellent qualitative and quantitative agreement of the digitally stained WLC (dsWLC) images with ground truth BLC images, including color consistency. Conclusions In short, dsWLC can affordably provide the fluorescent contrast needed to improve the detection sensitivity of bladder cancer, thereby increasing the accessibility of BLC contrast for bladder cancer surveillance. The broader implications of this work suggest digital staining is a cost-effective alternative to contrast-based endoscopy for other clinical scenarios outside of urology that can democratize access to better healthcare.

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Low-cost and label-free blue light cystoscopy through digital staining of white light cystoscopy videos

Chang,

Wintergerst,

Carlson

et al. 2024

Commun Med

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Programmed death receptor (PD-)1/PD-ligand (L)1 in urological cancers : the “all-around warrior” in immunotherapy

Liu,

Guan,

2024

Mol Cancer

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Optimizing cystoscopy and TURBT: enhanced imaging and artificial intelligence

Cited by 2 publications

References 90 publications

Low-cost and label-free blue light cystoscopy through digital staining of white light cystoscopy videos

Low-cost and label-free blue light cystoscopy through digital staining of white light cystoscopy videos

Programmed death receptor (PD-)1/PD-ligand (L)1 in urological cancers : the “all-around warrior” in immunotherapy

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