Optimizing Diagnostic Accuracy and Treatment Decisions in Men With Testosterone Deficiency

Bhasin, Shalender; Ozimek, Noelle

doi:10.1016/j.eprac.2021.08.002

Cited by 8 publications

(3 citation statements)

References 76 publications

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“…The main citing articles in this cluster were written by Burté [ 107 ] and Bhasin and Ozimek [ 108 ]. They had a GCS of 4 and 3, and a coverage of 5 and 3, respectively.…”

Section: Discussionmentioning

confidence: 99%

Understanding Sleep Disturbances in Prostate Cancer—A Scientometric Analysis of Sleep Assessment, Aetiology, and Its Impact on Quality of Life

Mangar

Abbadasari²,

Carollo

et al. 2023

Cancers

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Prostate cancer is the most commonly diagnosed cancer in the United Kingdom. While androgen-deprivation therapy is the most common treatment for prostate cancer, patients undergoing this treatment typically experience side effects in terms of sleep disturbances. However, the relation between prostate cancer and sleep and the way in which sleep interventions may benefit oncological patients is underinvestigated in the literature. The current study aims to review in a data-driven approach the existing literature on the field of prostate cancer and sleep to identify impactful documents and major thematic domains. To do so, a sample of 1547 documents was downloaded from Scopus, and a document co-citation analysis was conducted on CiteSpace software. In the literature, 12 main research domains were identified as well as 26 impactful documents. Research domains were examined regarding the link between prostate cancer and sleep, by taking into account variations in hormonal levels. A major gap in the literature was identified in the lack of use of objective assessment of sleep quality in patients with prostate cancer.

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“…The main citing articles in this cluster were written by Burté [ 107 ] and Bhasin and Ozimek [ 108 ]. They had a GCS of 4 and 3, and a coverage of 5 and 3, respectively.…”

Section: Discussionmentioning

confidence: 99%

Understanding Sleep Disturbances in Prostate Cancer—A Scientometric Analysis of Sleep Assessment, Aetiology, and Its Impact on Quality of Life

Mangar

Abbadasari²,

Carollo

et al. 2023

Cancers

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“…When SHBG is above the reference range, calculated free testosterone may help diagnose hypogonadism despite normal total testosterone levels. 23 When SHBG is below the reference range, calculated free testosterone may help exclude hypogonadism despite low total testosterone levels. Therefore, it is recommended to check SHBG in men with conditions likely to cause abnormal SHBG and men with borderline total testosterone.…”

Section: Recommendationsmentioning

confidence: 99%

Standardising the biochemical confirmation of adult male hypogonadism; a joint position statement by the Society for Endocrinology and Association of Clinical Biochemistry and Laboratory Medicine*

Jayasena,

de Silva,

O’Reilly

et al. 2023

Ann Clin Biochem

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Background: Inter-assay variation between different immunoassays and different mass spectrometry methods hampers the biochemical confirmation of male hypogonadism. Furthermore, some laboratories utilis eassay manufacturer reference ranges that do not necessarily mirror assay performance characteristics, with the lower limit of normality ranging from 4.9 nmol/L to 11 nmol/L. The quality of the normative data underlying commercial immunoassay reference ranges is uncertain. Design: A working group reviewed published evidence and agreed upon standardised reporting guidance to augment total testosterone reports. Results: Evidence-based guidance on appropriate blood sampling, clinical action limits, and other major factors likely to affect the interpretation of results are provided. Conclusions: This article aims to improve the quality of the interpretation of testosterone results by non-specialist clinicians. It also discusses approaches for assay harmonisation which have been successful in some but not all healthcare systems.

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“…It has recently been proposed that the use of AAS (more specifically TRT) should be based on a patient-centered perspective, taking into account the balance between benefit and risk of AAS prescription ( Bhasin, 2021 ; Bhasin and Ozimek, 2021 ). Thus, the use of AAS can be favored when it is also indicated for other clinical conditions that coexist with sarcopenia.…”

Section: Anabolic-androgenic Steroids When Exercise Seems Ineffective...mentioning

confidence: 99%

Anabolic-Androgenic Steroids and Exercise Training: Breaking the Myths and Dealing With Better Outcome in Sarcopenia

2022

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Sarcopenia is an emerging clinical condition determined by the reduction in physical function and muscle mass, being a health concern since it impairs quality of life and survival. Exercise training is a well-known approach to improve physical capacities and body composition, hence managing sarcopenia progression and worsening. However, it may be an ineffective treatment for many elderly with exercise-intolerant conditions. Thus, the use of anabolic-androgenic steroids (AAS) may be a plausible strategy, since these drugs can increase physical function and muscle mass. The decision to initiate AAS treatment should be guided by an evidence-based patient-centric perspective, once the balance between risks and benefits may change depending on the clinical condition coexisting with sarcopenia. This mini-review points out a critical appraisal of evidence and limitation of exercise training and AAS to treat sarcopenia.

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Optimizing Diagnostic Accuracy and Treatment Decisions in Men With Testosterone Deficiency

Cited by 8 publications

References 76 publications

Understanding Sleep Disturbances in Prostate Cancer—A Scientometric Analysis of Sleep Assessment, Aetiology, and Its Impact on Quality of Life

Understanding Sleep Disturbances in Prostate Cancer—A Scientometric Analysis of Sleep Assessment, Aetiology, and Its Impact on Quality of Life

Standardising the biochemical confirmation of adult male hypogonadism; a joint position statement by the Society for Endocrinology and Association of Clinical Biochemistry and Laboratory Medicine*

Anabolic-Androgenic Steroids and Exercise Training: Breaking the Myths and Dealing With Better Outcome in Sarcopenia

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