Optimizing test approaches for the detection of exposed metal surfaces within a chromatographic flow path

Simeone, Jennifer; Patel, Amit; DeLano, Mathew; Shiner, Stephen; Hoyes, Emmy; Tracey, Francis; Lauber, Matthew

doi:10.1016/j.chroma.2022.462855

Journal of Chromatography A

2022

DOI: 10.1016/j.chroma.2022.462855

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Optimizing test approaches for the detection of exposed metal surfaces within a chromatographic flow path

Jennifer Simeone

Amit Patel

Mathew DeLano

et al.

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Cited by 3 publications

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Oligonucleotide therapeutics in sports? An antidoping perspective

Parr,

Keiler

2024

Archiv der Pharmazie

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Within the last two decades, the European Medicines Agency and the US Food and Drug Administration have approved several gene therapies. One category is oligonucleotide therapeutics, which allow for the regulation of the expression of target genes. Besides already approved therapeutics, there are several preclinical and clinical trials ongoing. The World Anti‐Doping Agency prohibits the use of “nucleic acids or nucleic acid analogs that may alter genome sequences and/or alter gene expression by any mechanism” as a nonspecified method at all times. Hence, the administration of nucleic acids or analogs by athletes would cause an Anti‐Doping Rule Violation. Herein, we discuss types of oligonucleotide therapeutics, their potential to be misused in sports, and considerations to sample preparation and mass spectrometric approaches with regard to antidoping analysis.

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Oligonucleotide therapeutics in sports? An antidoping perspective

Parr,

Keiler

2024

Archiv der Pharmazie

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Managing nonspecific adsorption to liquid chromatography hardware: A review

Guimaraes

Bartlett

2023

Analytica Chimica Acta

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Investigation of several chromatographic approaches for untargeted profiling of central carbon metabolism

Girel

Guillarme

Fekete³

et al. 2023

Journal of Chromatography A

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Optimizing test approaches for the detection of exposed metal surfaces within a chromatographic flow path

Cited by 3 publications

References 16 publications

Oligonucleotide therapeutics in sports? An antidoping perspective

Oligonucleotide therapeutics in sports? An antidoping perspective

Managing nonspecific adsorption to liquid chromatography hardware: A review

Investigation of several chromatographic approaches for untargeted profiling of central carbon metabolism

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