Optimizing the extraction of phenolic antioxidants from date palm fruit by simplex-centroid solvent mixture design

Jdaini, Kawtar; Alla, Fouzia; Mansouri, Farid; Parmar, Aditya; Elhoumaizi, Mohammed Aziz

doi:10.1016/j.heliyon.2022.e12738

Cited by 10 publications

(9 citation statements)

References 42 publications

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“…Interestingly, the extracts using ternary blends with a high proportion of water and ethanol (E10 and E9) showed antioxidant capacity values similar to those of the aqueous organic binary mixtures ( Figure 2 A–C). These results showed that extracts obtained using a mixture with a higher proportion of polar solvents have a better antioxidant capacity; this behavior was also observed by Jdaini et al (2023) and Ameer et al (2017) [ 31 , 35 ]. In general, the antioxidant capacity ( Figure 2 ) and the phenolic and flavonoid contents ( Figure 1 ) results presented similar behaviors, suggesting that polyphenol content and the antioxidant capacity are directly proportional, which was confirmed through the Pearson correlation coefficient analysis ( r 2 ).…”

Section: Resultssupporting

confidence: 78%

“…Recent studies have shown that organic polar solvents (e.g., methanol, ethanol, acetone) mixed with water can substantially enhance the extraction of polyphenolic compounds owing to the greater polarity of polar organic solvents in aqueous mixtures [ 27 , 28 ]. One possible way to obtain a desirable solvent mixture that allows for high recovery of polyphenolic compounds is to use a simplex–centroid mixture design [ 29 , 30 , 31 ]. Therefore, the first aim of this study was to systematically optimize the proportions of the polar mixture components (acetone, ethanol, and water) using a mixture design.…”

Section: Introductionmentioning

confidence: 99%

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Agave angustifolia Haw. Leaves as a Potential Source of Bioactive Compounds: Extraction Optimization and Extract Characterization

Bermúdez-Bazán,

Estarrón-Espinosa,

Castillo-Herrera

et al. 2024

Molecules

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The leaves of Agave angustifolia Haw. are the main agro-waste generated by the mezcal industry and are becoming an important source of bioactive compounds, such as phenolic compounds, that could be used in the food and pharmaceutical industries. Therefore, the extraction and identification of these phytochemicals would revalorize these leaf by-products. Herein, maceration and supercritical carbon dioxide (scCO2) extractions were optimized to maximize the phenolic and flavonoid contents and the antioxidant capacity of vegetal extracts of A. angustifolia Haw. In the maceration process, the optimal extraction condition was a water–ethanol mixture (63:37% v/v), which yielded a total phenolic and flavonoid content of 27.92 ± 0.90 mg EAG/g DL and 12.85 ± 0.53 µg QE/g DL, respectively, and an antioxidant capacity of 32.67 ± 0.91 (ABTS assay), 17.30 ± 0.36 (DPPH assay), and 13.92 ± 0.78 (FRAP assay) µM TE/g DL. Using supercritical extraction, the optimal conditions for polyphenol recovery were 60 °C, 320 bar, and 10% v/v. It was also observed that lower proportions of cosolvent decreased the polyphenol extraction more than pressure and temperature. In both optimized extracts, a total of 29 glycosylated flavonoid derivatives were identified using LC-ESI-QTof/MS. In addition, another eight novel compounds were identified in the supercritical extracts, showing the efficiency of the cosolvent for recovering new flavonoid derivatives.

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Section: Resultssupporting

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Agave angustifolia Haw. Leaves as a Potential Source of Bioactive Compounds: Extraction Optimization and Extract Characterization

Bermúdez-Bazán,

Estarrón-Espinosa,

Castillo-Herrera

et al. 2024

Molecules

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“…Several types of orchids have great potential to be utilized in the pharmaceutical industry, such as the genus Dendrobium, Ceologyne, Vanda, Anoectochilus , and Bletilla . [ 17 ] Limited research regarding the Phalaenopsis genus’s potential exploration has been reported. Generally, the Phalaenopsis genus is used in plant breeding to improve floricultural properties.…”

Section: R Esults and Discussionmentioning

confidence: 99%

D-optimal Design Optimization of Solvent Mixture for Flavonoid Extraction from Phalaenopsis Leaves with Antioxidant Activity

Sanjaya,

Sudarsono,

Chan

et al. 2024

Journal of Pharmacy and Bioallied Sciences

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Aims: This study aimed to optimize the extraction of flavonoids and antioxidants from Phalaenopsis leaves by using solvent mixtures. Method: The total flavonoid content (TFC) and antioxidant activity were evaluated using the colorimetric method and ferric-reducing antioxidant power (FRAP), respectively. Maceration extracts from fresh leaves were used for the analysis. The study used the Design Expert 13.0 program to optimize the solvents (water, acetone, and methanol) and their combined ratio. Result: The results showed that 100% acetone was the best solvent for both responses, with a desirability value of 0.884, TFC of 0.434 mg QE/g fresh weight (FW) and FRAP of 713.53 μmol TE/g FW. Screening of the most potent Phalaenopsis genotypes for obtaining the most active leaf extract showed that P. amboinensis and P. pantherina were the best genotypes for TFC (0.786–0.797 mg QE/g FW) and FRAP activity (862.25–891.48 μmol TE/g FW). Conclusion: This study demonstrates an easy and useful way to obtain flavonoids and antioxidants from Phalaenopsis materials that can be used in the flower-based industry to make new functional ingredients.

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“…It is therefore critical to optimize these process variables to achieve maximum yields of bioactive compounds from raw materials. In recent years, response surface methodology (RSM) has been recognized as an effective tool for optimizing the extraction process [ 9 , 16 , 17 ]. It reduces the number of experimental trials and recognizes the influence of process parameters on the efficiency of extraction [ 9 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, response surface methodology (RSM) has been recognized as an effective tool for optimizing the extraction process [ 9 , 16 , 17 ]. It reduces the number of experimental trials and recognizes the influence of process parameters on the efficiency of extraction [ 9 , 16 ]. The response surface methodology also serves as a visual aid to indicate the optimization region [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Optimization Conditions of Ultrasound-Assisted Extraction for Phenolic Compounds and Antioxidant Activity from Rubus alceifolius Poir Leaves

Tran,

Nghiem,

Dinh

et al. 2023

International Journal of Food Science

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Rubus alceifolius Poir (R.A. Poir) leaves are rich in phenolic compounds, offering many health benefits due to their incredible antioxidant potential. In this study, conditions for the ultrasound-assisted extraction (UAE) of phenolic compounds and antioxidant activity from R.A. Poir leaves were optimized using response surface methodology (RSM). This methodology assessed the effects of ultrasound power ( X 1 : 100-500 W), extraction temperature ( X 2 : 30-60°C), and extraction time ( X 3 : 5-55 min). The optimized UAE conditions were then compared with conventional extraction methods (Soxhlet extraction: SE and maceration extraction: ME) for extracting total phenolics. A phenolic profile using GC-MS and antioxidant activity (ABTS) was also compared. According to the RSM, the best conditions for UAE to extract the highest total polyphenol content and ABTS radical scavenging activity were 320 W ultrasound power, 40°C extraction temperature, and 35.5 min sonication duration. Under these optimal conditions, the TPC and antioxidant activity reached 16.68 mg GAE/g dm and 21.9 mg TE/g, respectively, closely aligning with the predicted values. The UAE extraction technique proved to be more efficient in extracting phenolics and antioxidant capacity (ABTS (2,2 ′ -azino-bis(3-ethylbenzthiazoline-6-sulphonic acid)) radical scavenging activity, and enzyme inhibition) compared to the conventional extraction methods (SE and ME). A GC-MS analysis identified 12 components, including 5 phenolics and 3 flavonoids, which likely contribute to the antioxidant activity. Consequently, the UAE method improved extraction efficiency within a shorter time frame, suggesting that UAE is a promising, efficient, and ecofriendly technology for extracting bioactive compounds from R.A. Poir leaves.

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Optimizing the extraction of phenolic antioxidants from date palm fruit by simplex-centroid solvent mixture design

Cited by 10 publications

References 42 publications

Agave angustifolia Haw. Leaves as a Potential Source of Bioactive Compounds: Extraction Optimization and Extract Characterization

Agave angustifolia Haw. Leaves as a Potential Source of Bioactive Compounds: Extraction Optimization and Extract Characterization

D-optimal Design Optimization of Solvent Mixture for Flavonoid Extraction from Phalaenopsis Leaves with Antioxidant Activity

Optimization Conditions of Ultrasound-Assisted Extraction for Phenolic Compounds and Antioxidant Activity from Rubus alceifolius Poir Leaves

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