Optimizing the use of ultrasound to deliver chemotherapeutic agents to cancer cells from polymeric micelles

Polymeric micelles: authoritative aspects for drug delivery

“…At both frequencies, the degradation appeared to be at a statistically significantly higher rate compared to samples that were not exposed to ultrasound. Lately, the group presented an artificial neural network model that attempted to predict the dynamic release of doxorubicin from P105 micelles under different ultrasonic power densities at 20 kHz [356]. The developed model could be used in optimizing the ultrasound application for targeted drug release at the tumor site by controlling power density and ultrasound duration via model predictive control.…”

Investigating the acoustic release of doxorubicin from targeted micelles

“…W1-38 fibroblasts) take up a lesser amount of the drug since they do not express the folate receptor when compared to Hela and MCF 7 cells (folate-positive cell lines). Studies have also shown that the number of folic acid targeting ligands needs to be optimized in order to optimize Dox uptake [7]. Furthermore, the folic acid/polymer ratio has been found to influence selective cytotoxicity, cellular uptake and intracellular localization of the drug delivery vehicle [8,9].…”

Ultrasonically triggered drug delivery: Breaking the barrier

“…Subsequently, another ANN model was built to predict the dynamic release of Dox from Pluronic ® P105 micelles using 20kHz US at different power densities, with the aim to design model predictive controllers [169,170].…”