Optoacoustic diagnostic modality: from idea to clinical studies with highly compact laser diode-based systems

Esenaliev, Rinat O.

doi:10.1117/1.jbo.22.9.091512

Cited by 20 publications

(14 citation statements)

References 49 publications

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“…One of the most important optoacoustic applications is oxygenation imaging, monitoring, and sensing (Esenaliev et al, 2002a , b ). They can be used for diagnostics and management of large populations of patients including those with traumatic brain injury (TBI), circulatory shock, stroke, patients undergoing surgery, anemic patients, neonatal patients, and fetuses during late-stage labor (Petrova et al, 2005 , 2009 ; Petrov et al, 2005 , 2006 , 2012a , b , 2014 , 2016 , 2017a , b ; Brecht et al, 2007 ; Esenaliev et al, 2016b ; Esenaliev, 2017 ; Herrmann et al, 2017 ).…”

Section: Origin Of High Contrast and Resolution In Optoacoustic Measumentioning

confidence: 99%

Optoacoustic Monitoring of Physiologic Variables

Esenaliev

2017

Front. Physiol.

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Optoacoustic (photoacoustic) technique is a novel diagnostic platform that can be used for noninvasive measurements of physiologic variables, functional imaging, and hemodynamic monitoring. This technique is based on generation and time-resolved detection of optoacoustic (thermoelastic) waves generated in tissue by short optical pulses. This provides probing of tissues and individual blood vessels with high optical contrast and ultrasound spatial resolution. Because the optoacoustic waves carry information on tissue optical and thermophysical properties, detection, and analysis of the optoacoustic waves allow for measurements of physiologic variables with high accuracy and specificity. We proposed to use the optoacoustic technique for monitoring of a number of important physiologic variables including temperature, thermal coagulation, freezing, concentration of molecular dyes, nanoparticles, oxygenation, and hemoglobin concentration. In this review we present origin of contrast and high spatial resolution in these measurements performed with optoacoustic systems developed and built by our group. We summarize data obtained in vitro, in experimental animals, and in humans on monitoring of these physiologic variables. Our data indicate that the optoacoustic technology may be used for monitoring of cerebral blood oxygenation in patients with traumatic brain injury and in neonatal patients, central venous oxygenation monitoring, total hemoglobin concentration monitoring, hematoma detection and characterization, monitoring of temperature, and coagulation and freezing boundaries during thermotherapy.

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Section: Origin Of High Contrast and Resolution In Optoacoustic Measumentioning

confidence: 99%

Optoacoustic Monitoring of Physiologic Variables

Esenaliev

2017

Front. Physiol.

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“…The three most decisive parameters of the pulsed laser source for this application are the peak power that determines the measurement distance, the pulse width that limits the spatial resolution and the repetition rate that defines the image acquisition time. Optoacoustic imaging techniques, which are also known as photoacoustic, such as Optoacoustic Tomography (OAT) [6], [7] and Optoacoustic Microscopy (OAM) [8], [9], are innovative biomedical imaging that combines the contrast and specificity of the optical imaging with the resolution of the ultrasound images. They are based on the optoacoustic effect, that describes the conversion of pulses of light absorbed by an objective into pressure waves.…”

Section: Introductionmentioning

confidence: 99%

Overdrive Short Pulse High Peak Power Diode Lasers Without Catastrophic Optical Damage

2021

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Light Imaging Detection and Ranging (LIDAR) and Optoacoustic biomedical imaging techniques are applications that have a specific laser source requirements: short pulses, high peak power per pulse and high repetition rates. A custom current driver has been designed to fulfill these requirements and characterized in order to generate high current short pulses to drive High Power Diode Lasers (HPDL) beyond their maximum rating value, with a maximum current capacity of 120 A in a range of less than 10 nanoseconds pulse width, rise times up to 2 ns and a repetition rate of 1 kHz. Four commercial HPDLs have been driven generating optical pulses of less than 10 ns and more than four times the maximum rated optical peak power. A single laser device reached a maximum peak power of 880.6 W at 6 ns pulse width, demonstrating stable operation without catastrophic optical damage and improving the typical operation characteristics of the HPDLs for high speed short pulse applications.

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“…Our long-term goal is to transform our transcranial PA imaging system into a safe, compact, and cost-effective form factor to facilitate its clinical translation. The investigation should be based on promising progress in compact light source (pulse laser diode [40], light-emitting diode [25], etc.) and ultra-portable ultrasound imaging systems [41][42][43].…”

Section: Discussionmentioning

confidence: 99%

Transcranial photoacoustic characterization of neurovascular physiology during early-stage photothrombotic stroke in neonatal piglets in vivo

Kang

Liu

Cao

et al. 2021

Preprint

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Perinatal ischemic stroke is estimated to occur in 1/2300–1/5000 live births, but early differential diagnosis from global hypoxia-ischemia is often difficult. In this study, we tested the ability of a hand-held transcranial photoacoustic (PA) imaging to non-invasively detect a focal photothrombotic stroke (PTS) within 2 hours of stroke onset in a gyrencephalic piglet brain. 17 stroke lesions of approximately 1-cm2 area were introduced randomly in anterior or posterior cortex via the light/dye PTS technique in anesthetized neonatal piglets (n = 11). The contralateral non-ischemic region served as control tissue for discrimination contrast for the PA hemoglobin metrics: HbO2 saturation, total hemoglobin (tHb), and individual quantities of oxygenated and deoxygenated hemoglobin (HbO2 and HbR). The PA-derived tissue HbO2 saturation at 2 hours yielded a significant separation between control and affected regions-of-interest (p < 0.0001), which were well matched with 24-hr post-stroke cerebral infarction confirmed in the triphenyltetrazolium chloride (TTC)-stained image. The quantity of HbO2 also displayed a significant contrast (p = 0.021), whereas tHb and HbR did not. The analysis on receiver operating characteristic curves and multivariate data analysis also agreed with the results above. This study shows that a hand-held transcranial PA neuroimaging can detect a regional thrombotic stroke in cerebral cortex of a neonatal piglet. In particular, we conclude that the HbO2 saturation metric can be used alone to identify regional stroke lesions. The lack of change in tHb may be related to arbitrary hand-held imaging configuration and/or entrapment of red blood cells within the thrombotic stroke.

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Optoacoustic diagnostic modality: from idea to clinical studies with highly compact laser diode-based systems

Cited by 20 publications

References 49 publications

Optoacoustic Monitoring of Physiologic Variables

Optoacoustic Monitoring of Physiologic Variables

Overdrive Short Pulse High Peak Power Diode Lasers Without Catastrophic Optical Damage

Transcranial photoacoustic characterization of neurovascular physiology during early-stage photothrombotic stroke in neonatal piglets in vivo

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