Oral Acetate Reduces a High Sugar Diet Induced Increased Susceptibility to Colitis

Fedorak, R; Gill, A. Wilson; Park, HeeKuk; Keshteli, Ammar Hassanzadeh; Ginter, Ruth; Hotte, Naomi; Madsen, Karen

doi:10.1016/s0016-5085(17)33378-4

Cited by 1 publication

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“…The protective role of SCFA against colonic inflammation has been greatly appreciated by many researchers 33 . SCFAs enhances the gut barrier function and decrease tumor formation in the colon and hence promote colonic health 34 . In the present study, DSS reduced the levels of lactate, acetate, propionate and butyrate while the three Bifidobacterial strains are able to prevent the drop in their levels in the caecum content relative to DSS fed mice.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory Bifidobacterium strains prevent dextran sodium sulfate induced colitis and associated gut microbial dysbiosis in mice

Singh

Bhatia

Khare

et al. 2020

Sci Rep

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Crohn’s and ulcerative colitis are common inflammatory conditions associated with Inflammatory bowel disease. Owing to the importance of diet based approaches for the prevention of inflammatory gut conditions, the present study was aimed to screen the human isolates of Bifidobacterium strains based on their ability to reduce LPS-induced inflammation in murine macrophage (RAW 264.7) cells and to evaluate prioritized strains for their preventive efficacy against ulcerative colitis in mice. Twelve out of 25 isolated strains reduced the production of LPS-induced nitric oxide and inflammatory cytokines. Furthermore, three strains, B. longum Bif10, B. breve Bif11, and B. longum Bif16 conferred protection against dextran sodium sulfate induced colitis in mice. The three strains prevented shortening of colon, spleen weight, percentage body weight change and disease activity index relative to colitis mice. Lower levels of Lipocalin-2, TNF-α, IL-1β and IL-6 and improved SCFA levels were observed in Bifidobacterium supplemented mice relative to DSS counterparts. Bacterial composition of B. longum Bif10 and B. breve Bif11 fed mice was partly similar to the normal mice, while DSS and B. longum Bif16 supplemented mice showed deleterious alterations. At the genus level, Bifidobacterium supplementation inhibited the abundances of pathobionts such as Haemophilus, Klebsiella and Lachnospira there by conferring protection.

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Section: Discussionmentioning

confidence: 99%