Oral administration of a hydrophilic extract of Polypodium leucotomos for the prevention of polymorphic light eruption

Tanew, Adrian; Radaković, Sonja; González, Salvador; Venturini, Marina; Calzavara‐Pinton, Piergiacomo

doi:10.1016/j.jaad.2010.09.773

Cited by 63 publications

(39 citation statements)

References 18 publications

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“…The patient consistently exercised sun avoidance, his liver function remained P. leucotomos has reported benefit in the prevention of idiopathic photodermatoses such as polymorphous light eruption (PLE) and has even been reported to induce remission in a patient with subacute cutaneous lupus erythematosus [4] [5]. The protective effects of P. leucotomos in these conditions are thought to occur via blocked production of UV-induced reactive oxygen species as well as the prevention of other UV-induced cellular damage [4].…”

Section: Discussionmentioning

confidence: 99%

“…The protective effects of P. leucotomos in these conditions are thought to occur via blocked production of UV-induced reactive oxygen species as well as the prevention of other UV-induced cellular damage [4]. Similarly, antioxidants such as ascorbic acid increase sun tolerability in erythropoietic protoporphyria and decrease porphyrin-induced cellular phototoxicity [6] [7].…”

Section: Discussionmentioning

confidence: 99%

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The Role of Polypodium leucotomos Extract in the Treatment of Porphyria Cutanea Tarda

Hatch¹,

Mask-Bull²,

Tarbox³

2017

OALib

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The dermatologic manifestations of porphyrias result from localized cutaneous formation of reactive oxygen species. The significance of these inflammatory mediators may extend beyond the skin, as increased oxidative stress may play a role in the systemic manifestations of porphyrias. Polypodium leucotomos is a tropical fern that has demonstrated antioxidant, anti-inflammatory and photoprotective properties. Although it has proven effective in the treatment of various photoaggravated dermatoses, we are unaware of any prior reports citing Polypodium leucotomos as a beneficial treatment option in the setting of porphyria cutanea tarda. We describe a patient with refractory porphyria cutanea tarda, who demonstrated dramatic improvement in cutaneous lesions following the initiation of Polypodium leucotomos extract. Due to its low toxicity and demonstrated direct interference in the production of inflammatory mediators are central to cutaneous manifestations of porphyrias, we propose consideration of Polypodium leucotomos as a potential therapeutic option for patients with porphyria cutanea tarda.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Role of Polypodium leucotomos Extract in the Treatment of Porphyria Cutanea Tarda

Hatch¹,

Mask-Bull²,

Tarbox³

2017

OALib

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“…Pode ser utilizada radiação UVA ou UVB isoladas. 14,83,84 Vários protocolos podem ser realizados, seguindo os princípios gerais dos fototestes: utilização de duas áreas simétricas preferencialmente envolvidas previamente pela dermatose, que são irradiadas ao longo de quatro a cinco dias com radiação UVA ou UVB. O local de realização dos testes é de extrema importância, uma vez que a sua realização em áreas de pele que não foram previamente envolvidas pela dermatose pode ocasionar falsos negativos.…”

Section: Histopatologiaunclassified

Fotodermatoses Autoimunes Parte I - Fisiopatologia e Diagnóstico

Sousa

Pinheiro

Páris

et al. 2018

SPDV

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RESUMO -As fotodermatoses autoimunes constituem um grupo heterogéneo de dermatoses idiopáticas que têm na sua génese alterações imunológicas atualmente não completamente esclarecidas. Este grupo inclui cinco entidades clinicamente distintaserupção polimorfa à luz, prurigo actínico, hydroa vacciniforme, dermite actínica crónica, urticária solar -, algumas potencialmente graves e com grande impacto na qualidade de vida dos doentes. A fisiopatologia das fotodermatoses autoimunes parece estar relacionada com a formação de fotoalergénios em respota à exposição solar. O mecanismo de reação de hipersensibilidade é variável entre as diferentes patologias. O diagnóstico das fotodermatoses autoimunes depende do reconhecimento das caraterísticas clínicas. A realização de fototestes permite a confirmação do diagnóstico e a determinação da radiação e dose limiar indutora. Numa altura em que a área da fotodermatologia tem vindo a perder gradualmente o seu impacto, propomos rever a fisiopatologia e abordagem diagnóstica atual das fotodermatoses autoimunes. Revista SPDV 75(4) 2017; Fotodermatoses auto-imunes: fisiopatologia e diagnóstico;Vírgínia C Sousa, Rita R Pinheiro, Filipa R Páris, Margarida Apetato, Gabriela M Pinto. PALAVRAS-CHAVE - INTRODUÇÃOAs fotodermatoses autoimunes são dermatoses fisiopatologicamente relacionadas entre si, mas com características clínicas distintas. Incluem-se neste grupo cinco patologias: erupção polimorfa à luz, prurigo actínico, hydroa vacciniforme, dermite actínica crónica e urticária solar.No presente artigo pretendemos rever a fisiopatologia das diferentes entidades clínicas, bem como o seu diagnóstico por fototestes.

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“…These parameters would also need to be compared with antihistamines or anticholinergic blockade, but may have shortcomings given the lack of demonstrated therapeutic or immunological effect of oral PLE extract on mast cells [3,[12][13][14]. Another study, published by Tanew et al [15], examined how oral PLE affected 35 patients with long-standing polymorphous light eruption, with 18 of the patients receiving mixed UVB while the remainder were exposed to UVA alone. The patients were given variable weight-based doses (B55 kg = 720 mg/day; 56-70 kg = 960 mg/day; [70 kg = 1,200 mg/day) after photoprovocation, which was on dosage day 7, with a second photoprovocation after 2 weeks.…”

Section: P Leucotomos Use In Idiopathic Dermatosesmentioning

confidence: 99%

Polypodium leucotomos: A Potential New Photoprotective Agent

Bhatia

2015

Am J Clin Dermatol

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As the understanding of the immune system pathways, cytokine balances, and cellular interactions continues to expand, so must the potential applications of therapies that can impact the process of diseases instead of just controlling their symptoms. In the case of Polypodium leucotomos extract, which is derived from a tropical fern of the Polypodiaceae family, the future potential of applications in dermatology and beyond will be better understood as its incorporation into daily routines gives rise to the development of new regimens. Clinicians may position this agent as an option for daily maintenance, accept its use in combinations, or use it as a template for further development of oral supplementation that may evolve into a true immunomodulator. The antioxidant activity of P. leucotomos extract is primarily driven by caffeic acid and ferulic acid, resulting in the control of cutaneous responses to ultraviolet-induced erythema, in the interception of inflammatory mechanisms, and the promotion of other cytotoxic responses. Histologically, the impact of P. leucotomos extract induces an effect on the overall reduction of angiogenesis, photocarcinogenesis, and solar elastosis, while on the cellular level there are improvements in cell membrane integrity and elastin expression. Future applications for P. leucotomos extract could include the potential for photoprotective effects, and subsequent research efforts should focus on determining the optimal dosage regimen, duration of action, and utility of combinations with sunscreens, among other outcomes. Recently published data have also demonstrated how the antioxidant effects of oral P. leucotomos extract can delay tumor development in mice models, suggesting there might be a protective role that could be described with further clinical research. In addition, it is important to recognize the distinction between photoprotection and chemoprevention, in that there has yet to be any in vivo or controlled clinical trial data in human subjects that show a role for P. leucotomos extract in the prevention of carcinogenesis.

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Oral administration of a hydrophilic extract of Polypodium leucotomos for the prevention of polymorphic light eruption

Cited by 63 publications

References 18 publications

The Role of Polypodium leucotomos Extract in the Treatment of Porphyria Cutanea Tarda

The Role of Polypodium leucotomos Extract in the Treatment of Porphyria Cutanea Tarda

Fotodermatoses Autoimunes Parte I - Fisiopatologia e Diagnóstico

Polypodium leucotomos: A Potential New Photoprotective Agent

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