Oral and intravenous glucose-induced insulin secretion in hyperthyroid patients

Ikeda, Tadasu; Fujiyama, K.; Hoshino, Tazue; Takeuchi, Tatsuo; Mashiba, Hiroto; Tominaga, Masato

doi:10.1016/0026-0495(90)90031-7

Cited by 13 publications

(11 citation statements)

References 22 publications

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“…The association between TH and insulin secretion has been investigated mainly in individuals with hyperthyroidism (10,(12)(13)(14)(15)(16)(17)(18)(19). A serendipitous, positive association between serum-FT 3 and an estimate of insulin production (calculated from the insulin clearance during the clamp and fasting insulin concentrations) was found in euthyroid, lean, healthy individuals (22).…”

Section: Discussionmentioning

confidence: 99%

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Free triiodothyronine plasma concentrations are positively associated with insulin secretion in euthyroid individuals

Ortega

Koška²,

Pannacciulli³

et al. 2008

European Journal of Endocrinology

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Background: Thyroid hormones (TH) may influence glucose metabolism. Hyperthyroid subjects have higher insulin secretion rates when compared with euthyroid individuals. Objective: To evaluate the association between TH concentrations and insulin secretion in euthyroid, healthy Pima Indian adults (nZ55, 29G7 years, females/males 36/19) with normal glucose tolerance (NGT) admitted to a Clinical Research Unit. Methods: TSH, free thyroxine (FT 4 ), 3,5,30 -L-tri-iodothyronine (FT 3 ), and fasting plasma insulin (FPI) concentrations were measured in fasting plasma samples, percentage of body fat (%BF) by dual energy x-ray absorptiometry (DXA), acute insulin response (AIR), and incremental area under the curve (AUC) of insulin in response to a 25 g intravenous glucose tolerance test (IVGTT) and 75 g oral glucose tolerance test (OGTT) respectively and insulin action (M) during an euglycemic clamp. Results: FT 3 concentrations were associated with FPI, AIR, and insulin AUC both before (rZ0.33, PZ0.01; rZ0.29, PZ0.03; and rZ0.35, PZ0.008 respectively) and after adjustment for age, sex, %BF, glucose (fasting concentrations or glucose AUC), and M (bZ0.09, PZ0.01; bZ0.16, PZ0.03; and bZ0.24, PZ0.0007 respectively). No associations were found for TSH or FT 4 . Conclusion: FT 3 was associated with several measurements of insulin secretion in euthyroid individuals with NGT. T 3 concentrations may play a role in the regulation of insulin secretion.

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Section: Discussionmentioning

confidence: 99%

“…Insulin secretion rates have been reported to be enhanced in thyrotoxic individuals when they are compared with the euthyroid situation or with control subjects (10,(12)(13)(14)(15)(16). However, other studies have also reported no differences (17,18) or even decreased (19,20) secretion rates.…”

Section: Introductionmentioning

confidence: 99%

Free triiodothyronine plasma concentrations are positively associated with insulin secretion in euthyroid individuals

Ortega

Koška²,

Pannacciulli³

et al. 2008

European Journal of Endocrinology

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“…Glucose intolerance has long been recognized to accompany hyperthyroidism but the mechanisms involved are complex. Glucose concentrations are raised during oral glucose tolerance testing in hyperthyroid patients (Cavagnini et al ., 1974; Shen & Davidson, 1985; Taylor et al ., 1985; Ikeda et al ., 1990) and largely return to normal with the restoration of euthyroidism (Shen & Davidson, 1985). The occurrence of both raised IGFBP‐1 concentrations and impaired glucose tolerance in hyperthyroidism suggests that the association may be causal.…”

mentioning

confidence: 99%

Association of elevated insulin‐like growth factor binding protein‐1 with insulin resistance in hyperthyroidism

Jenkins

Valcavi²,

Zini³

et al. 2000

Clinical Endocrinology

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“…Ikeda et al [24] demonstrated that insulin secretion in proportion to a blood sugar stimulus was significantly reduced in hyperthyroid patients, and that this abnormality normalized with the achievement of a euthyroid state. However, insulin secretion during intravenous glucose tolerance testing was not impaired, suggesting a possible role of incretins in the impaired insulin secretion during the OGTT.…”

Section: Discussionmentioning

confidence: 99%

Insulin Sensitivity and Beta-Cell Function in Graves’ Disease and Their Changes with the Carbimazole-Induced Euthyroid State

et al. 2019

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Background and Objective: Thyroid hormones play an important role in intermediate metabolism, and abnormal glucose tolerance is often observed in patients with hyperthyroidism. Several pathogenic mechanisms have been proposed as contributors. However, there is no conclusive evidence in the existing literature regarding the predominant underlying pathophysiology. Our objective was to determine the changes in insulin resistance parameters and beta-cell function in patients with Graves’ disease following restoration of a euthyroid state. Methodology: This was an observational study with a before-after study design. Forty-five treatment-naïve adults with Graves’ diseases were included and 36 completed the study. An oral glucose tolerance test was performed at baseline and after 3 months of achieving a stable euthyroid state to assess glucose tolerance, insulin sensitivity, and beta-cell function. All patients were treated with antithyroid medication. The outcome measures studied were the Homeostasis Model Assessment-2 Insulin Resistance (HOMA2-IR), Matsuda index, and Insulin Secretion-Sensitivity Index (ISSI)-2. Results: Two-thirds of the patients had abnormal glucose tolerance at baseline. Among those with abnormal glucose tolerance at baseline, 34.7% had persistent abnormality during follow-up. During follow-up, no significant change was noted in the indices of insulin resistance. Patients with abnormal glucose tolerance had a significantly lower ISSI-2 index at baseline and it improved after achieving a euthyroid state. Conclusions: Abnormal glucose tolerance is a significant metabolic consequence in patients with Graves’ disease. Decreased beta-cell function was observed among those with abnormal glucose tolerance and it improved during follow-up. In a proportion of patients, abnormal glucose tolerance persisted after 3 months, emphasizing the need for continued follow-up.

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Oral and intravenous glucose-induced insulin secretion in hyperthyroid patients

Cited by 13 publications

References 22 publications

Free triiodothyronine plasma concentrations are positively associated with insulin secretion in euthyroid individuals

Free triiodothyronine plasma concentrations are positively associated with insulin secretion in euthyroid individuals

Association of elevated insulin‐like growth factor binding protein‐1 with insulin resistance in hyperthyroidism

Insulin Sensitivity and Beta-Cell Function in Graves’ Disease and Their Changes with the Carbimazole-Induced Euthyroid State

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