Oral anticoagulation and hip fracture risk: a common misconception?

Abstract

http://onlinelibrary.wiley.com/doi/10.1111/joim.12774/full.

Poor Vitamin K Status in Chronic Kidney Disease: An Indirect Indicator of Hip Fragility

“…I agree with the authors that the mechanisms involved are unclear, whereas accumulating evidence would not support the direct causality link between vitamin K status and aBMD in the femoral neck. As I have recently pointed out, (2) the latest meta-analysis reconfirmed that use of vitamin K antagonists did not cause an increased risk of fractures at least undoubtedly in the hip (OR 0.91, 95% CI, 0.69 to 1.20). (3) Here I would like to address the present timely and important issues from a different point of view.…”

Reply: Oral anticoagulation and hip fracture risk: a common misconception?

“…Sugiyama addresses whether oral anticoagulation (OAC) therapy and especially vitamin K antagonists (VKAs) increase the risk of hip fractures . In a study by Sugiyama and colleagues from 2007, they showed that VKAs lowered the level of osteocalcin in bones in rats .…”