Oral antioxidant supplementation does not prevent acute mountain sickness: double blind, randomized placebo-controlled trial

Baillie, J Kenneth; Thompson, A. A. Roger; Irving, John B.; Bates, Matthew; Sutherland, Andrew; MacNee, William; Maxwell, Simon; Webb, David J.

doi:10.1093/qjmed/hcp026

Cited by 91 publications

(60 citation statements)

References 33 publications

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“…By combining antioxidants with foods which have high unsaturated fat, the tests were able to prevent the onset of rancidity -a nasty process by which the unsaturated fats break down and produce a rancid-like smell and taste. 3 As this process continued; new information was brought to light, it was quickly discovered that a few of the key and vital vitamins -essential in the human diet -were actually able to be classified as antioxidants too. This meant that over the past 1000 years, people had been consuming antioxidants on a daily basis.…”

Section: Introductionmentioning

confidence: 99%

Antioxidants: An Overview on the Natural and Synthetic Types

Atta¹,

Mohamed²,

Abdelgawad³

2017

ECB

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Section: Introductionmentioning

confidence: 99%

Antioxidants: An Overview on the Natural and Synthetic Types

Atta¹,

Mohamed²,

Abdelgawad³

2017

ECB

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“…Antioxidants are widely used in dietary supplements and have been investigated for the prevention of diseases such as cancer, coronary heart disease, and even altitude sickness (Baillie et al, 2009;Prabhat et al, 1995). They are also used as preservatives in food and cosmetics and to prevent the degradation of rubber and gasoline (Dabelstein et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Chemical composition and bioactivity of the volatile oil from leaves and stems ofEucalyptus cinerea

Soliman

Fathy

Salama

et al. 2014

Pharmaceutical Biology

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Context: Eucalyptus cinerea F. Muell. ex Benth. (Myrtaceae) is a medium-sized tree cultivated in Egypt. Objective: First, to determine the chemical composition of the volatile oil of the juvenile leaves and stems of E. cinerea to identify its chemotype. Second, to study the in vivo antioxidant activity and in vitro antimicrobial activity of the studied volatile oils against selected Grampositive, Gram-negative bacteria, yeast, and mycelia fungi. Materials and methods: The volatile oil was prepared by hydrodistillation and then identified by GC/MS analysis. Broth microdilution and agar dilution methods were applied for determining the MIC. The antioxidant activity was studied by determination of glutathione level in blood of alloxan-induced diabetic rats. Results: The yield of the volatile oil hydrodistilled from the juvenile leaves and stems of E. cinerea was 4.5 and 0.5%, respectively. 1,8-Cineole was the major identified oxygenated monoterpenoid (84.55% and 60.15% in the juvenile leaves and stems, respectively). The antibacterial activity of the oil of the juvenile leaves was more potent against all the tested organisms than that of the stems. The (MIC) of volatile oil of the juvenile leaves against Escherichia coli, Pseudomonas aeruginosa, Streptococcus faecalis, Candida albicans, and Aspergillus flavus were 5.2, 5.6, 4, 4.8, and 12.8 mg/ml, respectively. Also, the juvenile leaves' oil was more active as an antioxidant than that of the stems. They restored glutathione level by 33.7 ± 1.1 and 29.6 ± 0.7 mg/dl, respectively, compared with vitamin E (35.9 ± 1.2 mg/dl) which was used as a reference. Discussion and conclusion: Results suggest that the volatile oil is 1,8-cineole chemotype. Moreover, the oil of the juvenile leaves of E. cinerea might find usefulness as a therapeutic agent following further development.

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“…The action of one antioxidant may therefore depend on the proper function of other members of the antioxidant system ] The amount of protection provided by any one antioxidant will also depend on its concentration, its reactivity towards the particular reactive oxygen species being considered, and the status of the antioxidants with which it interacts Some compounds contribute to antioxidant defense by chelating transition 9 metals and preventing them from catalyzing the production of free radicals in the cell. Ascorbicacid or"vitaminC"isa monosaccharide oxidationreduction 1 Glutathione is a cysteine-containing peptide found in most forms of aerobic acid. It is not required in the diet and is instead synthesized in cells from its constituent amino acids.…”

Section: Discussionmentioning

confidence: 99%

Anti oxidants

Islam

Pervin

2012

J. Dhaka Natl. Med. Coll. Hosp.

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Most of the human diseases are due to anti -oxidant deficiency or imbalance in the body. In the twenty-first century, knowledge about anti -oxidant is very essential and it is almost impossible to ignore. Anti -oxidant. Modern medical science development without the knowledge or some ideas about free radical cannot beaccepted. So it is impossible to improve the medical science without the sufficient knowledge of antioxidants. Oxidative stress appears to be an important part of many human diseases, the use of antioxidants in pharmacology is ntensively studied, particularly as treatments for stroke and neurodegenerative diseases and age related macular degeneration. Antioxidants are frequently added to industrial products. A common use is as stabilizers in fuels and lubricants to prevent oxidation, and in gasolines to prevent the polymerization that leads to the formation of engine-fouling residues.They are widely used to prevent the oxidative degradation of polymers such as rubbers, plastics and adhesives that causes a loss of strength and flexibility in these materials.

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Oral antioxidant supplementation does not prevent acute mountain sickness: double blind, randomized placebo-controlled trial

Abstract: NCT00664001.

Cited by 91 publications

References 33 publications

Antioxidants: An Overview on the Natural and Synthetic Types

Antioxidants: An Overview on the Natural and Synthetic Types

Chemical composition and bioactivity of the volatile oil from leaves and stems ofEucalyptus cinerea

Anti oxidants

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