Oral Application of Colostrum and Mother’s Own Milk in Preterm Infants—A Randomized, Controlled Trial

Sudeep, K; Kumar, Jogender; Ray, Santanu; Dutta, Sourabh; Aggarwal, Ritu; Prabhash, Kumar

doi:10.1007/s12098-021-03982-4

Cited by 19 publications

(31 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We performed a sensitivity analysis after excluding studies at a high risk of bias (see Supporting Information S9: Digital Content Table 9, which shows the sensitivity analysis). Meta‐analysis of remaining studies showed a benefit of OPCA on culture‐proven sepsis (14 studies, 1638 neonates, RR 0.78, 95% CI: 0.64, 0.96), mortality (13 studies, 1616 neonates, RR 0.78, 95% CI: 0.61, 0.99), and time to full enteral feeds (13 studies, 1336 neonates, MD: −2.17 days, 95% CI: −3.83 days, −0.52 days) 7,11,14–16,21,22,24,27,29,30,32,33 …”

Section: Resultsmentioning

confidence: 99%

“…Meta-analysis of remaining studies showed a benefit of OPCA on culture-proven sepsis (14 studies, 1638 neonates, RR 0.78, 95% CI: 0.64, 0.96), mortality (13 studies, 1616 neonates, RR 0.78, 95% CI: 0.61, 0.99), and time to full enteral feeds (13 studies, 1336 neonates, MD: −2.17 days, 95% CI: −3.83 days, −0.52 days). 7,11,[14][15][16]21,22,24,27,29,30,32,33…”

Section: Sensitivity Analysismentioning

confidence: 99%

See 1 more Smart Citation

Effect of oropharyngeal colostrum therapy on neonatal sepsis in preterm neonates: A systematic review and meta‐analysis

Anne,

Kumar,

Kumar

et al. 2023

J. pediatr. gastroenterol. nutr.

Self Cite

View full text Add to dashboard Cite

Various studies have shown that oropharyngeal colostrum application (OPCA) is beneficial to preterm neonates. We performed a systematic review and meta‐analysis to assess whether OPCA reduces the incidence of culture‐proven neonatal sepsis in preterm neonates. Randomized controlled trials comparing OPCA with placebo or standard care in preterm neonates were included. Medline, Embase, Web of Science, Cumulated Index to Nursing and Allied Health Literature, Scopus, and CENTRAL were searched for studies published up to June 15, 2023. We used the Cochrane Risk of Bias tool, version 2, for risk of bias assessment, the random‐effects model (RevMan 5.4) for meta‐analysis, and Gradepro software for assessing the certainty of evidence. Twenty‐one studies involving 2393 participants were included in this meta‐analysis. Four studies had a low risk of bias, whereas seven had a high risk. Oropharyngeal colostrum significantly reduced the incidence of culture‐proven sepsis (18 studies, 1990 neonates, risk ratio [RR]: 0.78, 95% confidence interval [95% CI]: 0.65, 0.94), mortality (18 studies, 2117 neonates, RR: 0.73, 95% CI: 0.59, 0.90), necrotizing enterocolitis (NEC) (17 studies, 1692 neonates, RR: 0.59, 95% CI: 0.43, 0.82), feeding intolerance episodes (four studies, 445 neonates, RR: 0.59, 95% CI: 0.38, 0.92), and the time to full enteral feeding (19 studies, 2142 neonates, mean difference: −2 to 21 days, 95% CI: −3.44, −0.99 days). There was no reduction in intraventricular hemorrhage, retinopathy of prematurity, bronchopulmonary dysplasia, ventilator‐associated pneumonia, neurodevelopmental abnormalities, hospital stay duration, time to full oral feeding, weight at discharge, pneumonia, and duration of antibiotic therapy. The certainty of the evidence was high for the outcomes of culture‐positive sepsis and mortality, moderate for NEC, low for time to full enteral feeding, and very low for feeding intolerance. OPCA reduces culture‐positive sepsis and mortality (high certainty), NEC (moderate certainty), and time to full enteral feeding (low certainty) in preterm neonates. However, scarcity of data from extremely premature infants limits the generalizability of these results to this population.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Sensitivity Analysismentioning

confidence: 99%

Effect of oropharyngeal colostrum therapy on neonatal sepsis in preterm neonates: A systematic review and meta‐analysis

Anne,

Kumar,

Kumar

et al. 2023

J. pediatr. gastroenterol. nutr.

Self Cite

View full text Add to dashboard Cite

show abstract

“…From the 42 studies left, after reviewing full-text articles, 29 were excluded (9 meta-analyses, 2 for outcomes, and 18 for the intervention). Terefore, a total of 13 RCTs [18,20,21,[28][29][30][31][32][33][34][35][36][37] were included in the fnal analysis (Table 1). At the end of our research, a total of 1330 infants were included in our analyses, with approximately 660 infants in each group.…”

Section: Selection and Characteristics Of The Studiesmentioning

confidence: 99%

“…Te assessment for the risk of bias for the included studies is presented in Table 2. Among the 13 randomized controlled trials [18,20,21,[28][29][30][31][32][33][34][35][36][37], the overall risk of bias was low in 8 studies [20,21,[28][29][30][31][33][34][35][36]. Two studies that did not describe the process of randomization and blinding were degraded according to the ROB-2 criteria [16,32].…”

Section: Quality Of the Included Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Oral Application of Mother’s Own Milk for Reducing Necrotizing Enterocolitis in Preterm Infants: An Updated Meta‐Analysis of RCTs

Peng

Qian

et al. 2023

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Background. Necrotizing enterocolitis (NEC) and late-onset sepsis (LOS) are the major contributors to mortality and morbidity in preterm infants. This updated meta-analysis was aimed to assess the effects of mother’s milk on the incidence of NEC, LOS, and other clinical outcomes in preterm infants. Methods. PubMed, Embase, and the Cochrane library were searched for papers published up to October 2022. Results. A total of 13 RCTs with 1330 infants were included in the final analysis. Significant difference in NEC (stage 2 or 3) was found between the intervention group and the control group (RR = 0.508, 95% CI: 0.314–0.822, and P = 0.008 ). The incidence of proven LOS (RR = 0.809, 95% CI: 0.610–1.071, and P = 0.139 ) and death (RR = 0.800, 95% CI: 0.571–1.122, and P = 0.196 ) was comparable between the two groups. Statistical differences in the incidence of proven or probable LOS (RR = 0.705, 95% CI: 0.577–0.862, and P = 0.001 ) and length of hospitalization (WMD = −4.868, 95% CI: −6.608 to −3.128, and P < 0.001 ) between the intervention group and the control group were observed. Conclusions. The results of this updated meta-analysis showed that compared to the placebo, mother’s milk provides better effects in reducing the incidences of NEC, proven or probable LOS, and the length of stay, whereas no significant benefit of mother’s milk was observed in reducing the incidence of proven LOS and death.

show abstract

Effects of oropharyngeal administration of own mother's milk on oral microbial colonization in very low birth weight infants fed by gastric tube: A randomized controlled trial

Liu,

Zhang,

Zhao

et al. 2024

Immunity Inflam & Disease

View full text Add to dashboard Cite

AimsThe aim of the present study was to explore the effect of oropharyngeal mother's milk administration on oral microbial colonization in infants fed by gastric tube at different time points.MethodsInfants (n = 116) with birth weight <1500 g were randomly allocated into two groups which both received breast milk for enteral nutrition. The control group (n = 51) accepted oropharyngeal normal saline administration. The experimental group (n = 53) accepted oropharyngeal mother's milk administration before fed by gastric tube once every 3 h over 21 days after birth. We analyzed the oral microbiota at initiation and 7 and 14 and 21 days later using 16S DNA amplicon sequencing.ResultsThere were no difference in oral microbial diversity between the two groups at any time point, but diversity decreased significantly over time in both groups. On the first day of life, the oral microbiota of the infant in the experimental and control groups consisted mainly of Firmicutes (7.75%, 6.18%) and Proteobacteria (68.65%, 68.69%), respectively. As time increases to 21 days after birth, Firmicutes (77.67%, 77.66%) had replaced Proteobacteria (68.65%, 68.69%) as the predominant phylum.DiscussionFrom birth to 21 days after birth, oropharyngeal mother's milk administration did not change the diversity and structural composition of the oral microbiota. The oral microbial diversity of infants declined significantly over time. Firmicutes had replaced Proteobacteria as the predominant phylum.

show abstract

Oral Application of Colostrum and Mother’s Own Milk in Preterm Infants—A Randomized, Controlled Trial

Cited by 19 publications

References 30 publications

Effect of oropharyngeal colostrum therapy on neonatal sepsis in preterm neonates: A systematic review and meta‐analysis

Effect of oropharyngeal colostrum therapy on neonatal sepsis in preterm neonates: A systematic review and meta‐analysis

Oral Application of Mother’s Own Milk for Reducing Necrotizing Enterocolitis in Preterm Infants: An Updated Meta‐Analysis of RCTs

Effects of oropharyngeal administration of own mother's milk on oral microbial colonization in very low birth weight infants fed by gastric tube: A randomized controlled trial

Contact Info

Product

Resources

About