Oral bicarbonate supplementation improves amino acid-induced gluconeogenesis and ureagenesis in hepatocytes isolated from uremic rats

Cano, Noël; Catelloni, F.; Novaretti, R.; Costanzo-Dufetel, J. Di; Reynier, J; Leverve, Xavier

doi:10.1016/0261-5614(94)90137-6

Cited by 5 publications

(1 citation statement)

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“…However, many experimental and clinical studies have reported the beneficial effects of correction of acidosis, particularly on protein metabolism (27). In rats with experimental chronic renal failure, correction of acidosis has been shown to improve muscle protein (6) and hepatocyte amino acid utilization (28). In a group of HD patients whose protein intake was maintained constant, Papadoyannakis et al (29) showed that supplementation with calcium carbonate increased the plasma bicarbonate concentration and reduced the protein catabolic rate from 1.2 g/kg/day to 1 g/kg/day.…”

Section: Discussionmentioning

confidence: 99%

ACID‐BASE IN RENAL FAILURE: Acidosis and Nutritional Status in Hemodialyzed Patients

Chauveau

Fouque

Combe³

et al. 2000

Seminars in Dialysis

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In a cross-sectional study of more than 30% of French dialysis patients (N = 7,123), we evaluated the relationships between predialysis plasma bicarbonate concentration and nutritional markers. Data including age, gender, cause of end-stage renal disease (ESRD), time on dialysis, body mass index (BMI), blood levels of midweek predialysis albumin, prealbumin, and bicarbonate were collected. Normalized protein catabolic rate (nPCR), dialysis adequacy parameters, and estimation of lean body mass (LBM) were computed from pre- and postbicarbonate-dialysis urea and creatinine levels according to the classical formulas of Garred. Average values (+/- 1 SD) were age 61 +/- 16 years, BMI 23.3 +/- 4.6 kg/m2, dialysis time 12.4 +/- 2.7 h/week, HCO3 22.8 +/- 3.5 mmol/L, albumin 38.7 +/- 5.3 g/L, prealbumin 340 +/- 90 mg/L, Kt/V 1.36 +/- 0.36, nPCR 1.13 +/- 0.32 g/kg BW/day, and LBM 0.86 +/- 0.21% of ideal LBM. A highly significant negative correlation was observed between predialysis bicarbonate levels (within a range of 16-30 mmol/L, 95% of this population) and nPCR confirmed by analysis of variance using bicarbonate classes (p < 0.0001). Bicarbonate was also negatively correlated with albumin, prealbumin, BMI, and LBM. No relationship was noted between bicarbonate and Kt/V despite a positive correlation between Kt/V and nPCR. It is likely that a persistent acidosis observed despite standard bicarbonate dialysis was caused by a high dietary protein intake which results in an increased acid load, but also overcomes the usual catabolic effects of acidosis.

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Section: Discussionmentioning

confidence: 99%