Oral changes in individuals undergoing hematopoietic stem cell transplantation

Barrach, Regina Haddad; Souza, Mair Pedro de; Silva, Daniela Polo Camargo da; Lopez, Priscila Suman; Montovani, Jair Cortez

doi:10.1016/j.bjorl.2014.04.004

Cited by 27 publications

(45 citation statements)

References 26 publications

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“…Our study cannot thoroughly confirm this previous finding. Likewise, a couple of studies with a 100‐day follow‐up did not notice any changes in DMFT index or an increase in new dental caries lesions in this short follow‐up period . However, in this study, hyposalivation was observed to be associated with progression towards a higher DMFT index score.…”

Section: Discussioncontrasting

confidence: 54%

“…Likewise, a couple of studies with a 100-day follow-up did not notice any changes in DMFT index or an increase in new dental caries lesions in this short follow-up period. 15,36 However, in this study, hyposalivation was observed to be associated with progression to- hypotheses and many previous studies where hyposalivation has been observed as a risk factor for oral diseases that may eventually lead to tooth loss and expensive oral rehabilitation. Additionally, caries prevalence was observed to be consistently higher in HSCT recipients with hyposalivation at all study time points, but the results were not statistically significant, except for HSCT recipients with hyposalivation pre-HSCT.…”

Section: Stimulated Saliva Flow Rates and Associations Of Hyposalivcontrasting

confidence: 56%

“…These studies suggest hyposalivation to be common and oral health to deteriorate after the HSCT. 8,12,15,27,35,36 Additionally, there are no studies on the effects of hyposalivation or the most common oral infections caries and periodontitis on survival post-HSCT. Thus, in this study, the prevalence, consequences and progression of caries and periodontitis, as well as hyposalivation were examined in a considerably large number of allogeneic HSCT recipients pre-and up to 24 months post-HSCT.…”

mentioning

confidence: 99%

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Common oral diseases, hyposalivation and survival post‐HSCT, a longitudinal study

Uutela

Passweg

Gerull

et al. 2019

European J of Haematology

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Objectives Haematopoietic stem cell transplantation (HSCT) recipients are at risk of side effects within the oral cavity. The purpose of this study was to examine progression of common oral diseases and hyposalivation and their associations with survival in allogeneic HSCT recipients. Methods Two hundred and sixty nine adult HSCT recipients treated with HSCT between 2008 and 2016 were included in this study. The associations of caries, decayed, missing, filled teeth (DMFT) index, radiological attachment loss and stimulated salivary flow rate with 6‐month survival and the progression of the oral disorders within 2 years were examined. Results Forty HSCT recipients (14.8%) deceased within 6 months post‐HSCT. Among the deceased recipients, hyposalivation and caries were more common pre‐HSCT than in recipients who survived over 6 months (P < 0.05). HSCT recipients with hyposalivation pre‐HSCT had higher risk of death (HR: 1.90, 95% CI:1.00‐3.60; P = 0.044) within 6 months post‐HSCT compared with recipients without hyposalivation. Hyposalivation pre‐HSCT was associated with a higher DMFT index score (P < 0.05) and a smaller number of teeth (P < 0.005) 24 months post‐HSCT in comparison with those without hyposalivation. Conclusions Hyposalivation and caries were associated with a lower rate of survival in HSCT recipients. Additionally, hyposalivation predisposed to deterioration of oral health post‐HSCT.

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Section: Discussioncontrasting

confidence: 54%

Section: Stimulated Saliva Flow Rates and Associations Of Hyposalivcontrasting

confidence: 56%

mentioning

confidence: 99%

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Common oral diseases, hyposalivation and survival post‐HSCT, a longitudinal study

Uutela

Passweg

Gerull

et al. 2019

European J of Haematology

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“…Hastalarda 2. ve 3. değerlendirmede immun supresyonda alınan ilaç toksisitesiyle ilişkili olarak oral mukozit yaygın görülmüştür. (10) Allojenik kök hücre transplantasyonu yapılan myeloid lösemi tanılı 48 hasta ile yapılan yarı deneysel çalışmada, Busulfan (3 gün busulfan, FB3) tedavisi alan hastalarda (n=27) Mephalan (FM140) tedavisi alan hastalara (n=21) göre istatistiksel olarak anlamlı bir şekilde (p=0.013) daha şiddetli stomatit görülmüştür. (11) Otolog kök hücre transplantasyonu öncesi yüksek doz kemoterapi alan multiple myelom (MM) ve non hodking lenfoma (NHL) tanılı hastalarda oral mukozit insidansı, süresi, mukozit şiddetini etkileyen etkenler transplantasyondan 30 gün sonrasına kadar değerlendirilmiştir.…”

Section: öZunclassified

Review of Oral Mucositis Studies in Post Stem Cell Transplant Patients

Yildirim¹,

Baykal²,

Can³

2018

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ÖZKök hücre transplantasyonu yapılan hastaların büyük kısmında oral mukozit, hastaların yaşam kalitesini olumsuz yönde etkileyen önemli sorunlardan biridir. Hastanın beslenmesini olumsuz etkileyerek, parenteral beslenmenin ve ağrıya neden olarak opioid tedavilerin baş-lanmasına neden olur. Hastanın hastanede kalış süresinin uzamasına neden olarak, hastane maliyetlerinin artmasına yol açmaktadır. Bazı hastalarda uzun süreli tedavi sonuçlarını da olumsuz etkileyebilmektedir. Yönetiminde, nakil öncesi hastanın diş hekimliğine yönlendirilerek diş bakımının yapılması, düşük doz lazer tedavi (DDLT) uygulanması, nakil sırasında temel ağız bakımının sürdürülmesi ve kriyoterapinin uygulanması etkinliği gösterilmiş non-farmakolojik yaklaşımlardır.Farklı çalışmalarda, kapsamlı ağız bakımının düzenli yapılması, var olan oral mukozitlerin şiddetini ve süresini azalttığı, DDLT şiddetli oral mukozitin gelişimini engellediği ve oluşan mukozitin iyileşme sürecini hızlandırdığı, tek başına DDLT uygulanması ile kıyaslandığında DDLT ile birlikte kriyoterapinin uygulanmasının oral mukozitlerin iyileştiril-mesinde daha yararlı olduğu saptanmıştır.Bu derleme kök hücre transplantasyonu tedavisi uygulanan hastalarda oral mukozite yönelik çalışmaların gözden geçirilmesi amacıyla yazıl-mıştır. ABSTRACTOral mucositis is one of the most important issues affecting the quality of life in the majority of patients undergoing stem cell transplantation. It negatively affects the nutrition of the patient and leads to the administration of parenteral nutrition as well as opioid therapies due to the onset of pain, a prolonged hospital stay, and an increase in hospital costs. It may also adversely affect long-term treatment results in some patients.Non-pharmacological approaches such as administering low-dose laser treatment (LDLT), maintaining basic oral care during transfer, and administering cryotherapy have been shown to be effective in oral care management.In different studies, it was found that regular oral care decreases the severity and duration of existing oral mucositis, LDLT prevents the development of severe oral mucositis and accelerates the mucositis recovery process, and cryotherapy with LDLT is more effective in the treatment of oral mucositis compared to LDLT alone. This review has been written to overview oral mucositis studies in post stem cell transplant patients.

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“…If it remains there, it can irritate the gum and lead to pericorinitis 8 . If the pericorinitis is severe overlooked, the swelling & infection may extend beyond the jaw to the check and neck 9,10 .…”

Section: Introductionmentioning

confidence: 99%