Oral Contrast Agents for Pediatric CT and MR Enterography:                     It’s a Matter of Good Taste

Frush, Donald P.

doi:10.1148/radiol.2018180718

Cited by 3 publications

(1 citation statement)

References 7 publications

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“…The results of this study, if externally validated, would improve this technique, especially in the era of patient-centered medicine. Furthermore, the issue of patient acceptance of PEG as a contrast agent is extremely relevant, in particular, in the pediatric population that often needs to undergo invasive procedures, such as nasogastric tube positioning, to administer an adequate amount of contrast agent, as reported in the literature [17,18]. The authors believe that their idea could be the starting point for future studies regarding this vulnerable population.…”

Section: Discussionmentioning

confidence: 97%

Magnetic Resonance Enterography Reinvented: Exploring the Potential of a New Natural Beverage as an Alternative to Polyethylene Glycol Solution

Renzulli

Cocozza

Biselli

et al. 2023

Gastroenterology Insights

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The aim of the present study was to test a new oral contrast medium composed of natural components for the magnetic resonance (MR) imaging of small bowel diseases. Between January 2018 and June 2019, 35 patients affected by ileocolic Crohn’s disease (CD) were enrolled in the present study. Each patient underwent two sequential MR enterographies, first with the standard polyethylene glycol (PEG) water solution and, after 3 weeks, with the new natural beverage designed by our team. At the end of the administration of each oral contrast, a satisfaction survey was given to the patients to assess the palatability of both beverages. The intestinal distention and the quality of images were evaluated by two expert radiologists for both studies and the interreader agreement was calculated. According to the satisfaction questionnaire, 97.1% of patients expressed positive judgments regarding the natural beverage (71.4% very good and 25.7% good) whereas only 8.6% of them appreciated the PEG water solution (8.6% good) (p = 0.0001). The degree of intestinal distention was excellent and good in 97.1% of patients after the administration of PEG and in 94.3% of the patients after the administration of the natural beverage, without significant differences between the two products and with almost perfect (k = 0.821) and substantial (k = 0.754) inter-observer variability, respectively. No statistical differences were observed between the two expert radiologists regarding the evaluation of the imaging quality; in particular, they were considered good and excellent in 100% of patients after the administration of PEG water solution and in 97.2% of those who took the natural beverage, with substantial (k = 0.618) and almost perfect (k = 0.858) inter-observer variability, respectively. The new natural beverage demonstrated the same intestinal distension and excellent image quality compared to the synthetic standard oral contrast administered during MRE for small bowel diseases, proving to be a valid alternative with better palatability.

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Section: Discussionmentioning

confidence: 97%

Magnetic Resonance Enterography Reinvented: Exploring the Potential of a New Natural Beverage as an Alternative to Polyethylene Glycol Solution

Renzulli

Cocozza

Biselli

et al. 2023

Gastroenterology Insights

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Pearls and Pitfalls in MR Enterography Interpretation for Pediatric Patients

Harrington

Johnson

Greer

et al. 2020

Seminars in Ultrasound, CT and MRI

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Development of Resorbable Phosphate-Based Glass Microspheres as MRI Contrast Media Agents

Molinar-Díaz,

Arjuna,

Abrehart

et al. 2024

Molecules

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In this research, resorbable phosphate-based glass (PBG) compositions were developed using varying modifier oxides including iron (Fe2O3), copper (CuO), and manganese (MnO2), and then processed via a rapid single-stage flame spheroidisation process to manufacture dense (i.e., solid) and highly porous microspheres. Solid (63–200 µm) and porous (100–200 µm) microspheres were produced and characterised via SEM, XRD, and EDX to investigate their surface topography, structural properties, and elemental distribution. Complementary NMR investigations revealed the formation of Q2, Q1, and Q0 phosphate species within the porous and solid microspheres, and degradation studies performed to evaluate mass loss, particle size, and pH changes over 28 days showed no significant differences among the microspheres (63–71 µm) investigated. The microspheres produced were then investigated using clinical (1.5 T) and preclinical (7 T) MRI systems to determine the R1 and R2 relaxation rates. Among the compositions investigated, manganese-based porous and solid microspheres revealed enhanced levels of R2 (9.7–10.5 s−1 for 1.5 T; 17.1–18.9 s−1 for 7 T) and R1 (3.4–3.9 s−1 for 1.5 T; 2.2–2.3 s−1 for 7 T) when compared to the copper and iron-based microsphere samples. This was suggested to be due to paramagnetic ions present in the Mn-based microspheres. It is also suggested that the porosity in the resorbable PBG porous microspheres could be further explored for loading with drugs or other biologics. This would further advance these materials as MRI theranostic agents and generate new opportunities for MRI contrast-enhancement oral-delivery applications.

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Oral Contrast Agents for Pediatric CT and MR Enterography: It’s a Matter of Good Taste

Cited by 3 publications

References 7 publications

Magnetic Resonance Enterography Reinvented: Exploring the Potential of a New Natural Beverage as an Alternative to Polyethylene Glycol Solution

Magnetic Resonance Enterography Reinvented: Exploring the Potential of a New Natural Beverage as an Alternative to Polyethylene Glycol Solution

Pearls and Pitfalls in MR Enterography Interpretation for Pediatric Patients

Development of Resorbable Phosphate-Based Glass Microspheres as MRI Contrast Media Agents

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