Oral cryotherapy can significantly reduce oral mucositis but not acute GVHD incidence in Flu/Mel conditioning allo-SCT

Vokurka, Samuel; Svoboda, Tomáš; Jungová, Alexandra; Karas, Michal; Koza, Vladimír

doi:10.1038/bmt.2011.156

Cited by 8 publications

(9 citation statements)

References 10 publications

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“…However, Vokurka et al, [68] found no evidence for this notion in a study in which OM was prevented by oral cryotherapy in allogeneic HSCT recipients treated with high-dose melphalan conditioning regimens [68]. …”

Section: Oral Mucositismentioning

confidence: 99%

Oral Complications in Hematopoietic Stem Cell Recipients: The Role of Inflammation

Haverman

Raber-Durlacher

Rademacher

et al. 2014

Mediators of Inflammation

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Hematopoietic stem cell transplantation (HSCT) is widely used as a potentially curative treatment for patients with various hematological malignancies, bone marrow failure syndromes, and congenital immune deficiencies. The prevalence of oral complications in both autologous and allogeneic HSCT recipients remains high, despite advances in transplant medicine and in supportive care. Frequently encountered oral complications include mucositis, infections, oral dryness, taste changes, and graft versus host disease in allogeneic HSCT. Oral complications are associated with substantial morbidity and in some cases with increased mortality and may significantly affect quality of life, even many years after HSCT. Inflammatory processes are key in the pathobiology of most oral complications in HSCT recipients. This review article will discuss frequently encountered oral complications associated with HSCT focusing on the inflammatory pathways and inflammatory mediators involved in their pathogenesis.

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Section: Oral Mucositismentioning

confidence: 99%

Oral Complications in Hematopoietic Stem Cell Recipients: The Role of Inflammation

Haverman

Raber-Durlacher

Rademacher

et al. 2014

Mediators of Inflammation

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“…There have been no more than 150 patients reported in the literature who underwent cryotherapy during melphalan infusion. In general, the prospective studies demonstrated a good response to minimizing OM severity during HSCT .…”

Section: Discussionmentioning

confidence: 85%

“…The principle of cryotherapy has not been fully elucidated. It has been postulated that reduction in the local temperature leads to vasoconstriction in the oral mucosa and decreases the exposure to melphalan . This temperature‐dependent reduction in the cytotoxicity of melphalan also induces impairment in the production of chemical mediators that are related to the pathogenesis of OM.…”

Section: Discussionmentioning

confidence: 99%

“…Non‐drug protocols for OM have been proposed, such as monitored oral hygiene, the use of ice chips, and laser therapy. The application of ice chips in the oral mucosa before and throughout the melphalan infusion significantly decreases the incidence and severity of OM . Laser therapy also decreases the duration and severity of OM and promotes accelerated mucosa repair in children and adults .…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of cryotherapy associated with laser therapy for decreasing severity of melphalan‐induced oral mucositis during hematological stem‐cell transplantation: a prospective clinical study

Eduardo

Bezinelli

Lopes

et al. 2014

Hematological Oncology

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Melphalan followed by hematopoietic stem-cell transplantation (HSCT) is the standard treatment for multiple myeloma and other hematopoietic neoplasms. However, high doses of melphalan cause severe oral mucositis (OM). The objective was to verify the efficacy of cryotherapy plus laser therapy on reduction of OM severity. HSCT patients undergoing melphalan chemotherapy (n = 71) were randomly divided into two groups according to OM treatment: oral cryotherapy performed with ice chips for 1 h 35 min followed by low-level laser therapy (InGaAIP, 660 nm, 40 mW, 6 J/cm(2) ) (n = 54) and laser therapy alone with the same protocol (n = 17). A control group (n = 33) was composed of HSCT patients treated with melphalan who received no specific treatment for OM. OM scores and clinical information were collected from D0 to D + 11. The cryotherapy/laser therapy group showed the lowest OM scores (maximum Grade I) and the lowest mean number of days (8 days) with OM in comparison with the other groups (p < 0.001). OM Grades III and IV were present with high frequency only in the control group. The association of cryotherapy with laser therapy was effective in reducing OM severity in HSCT patients who underwent melphalan conditioning.

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“…In standard radiotherapy protocols, however, this intervention is ineffective (19)(20)(21). Oral cryotherapy can significantly reduce oral mucositis in Fluorouracil/Melphalan conditioning allogenic Stem Cell Transplantation (22,23).…”

Section: Cryotherapy (Ice Chips)mentioning

confidence: 98%

Management of oral mucositis

Mota¹,

Brasil²,

Ribeiro³

et al. 2012

Arch Oncol

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Oral mucositis is one of the most common oral complications of cancer treatment. Studies have shown some interventions that reduce the severity of this condition, but there is not a specific treatment proved that really prevents or treats mucositis efficiently. The aim of this paper was to provide a literature review for better understanding of the management of oral mucositis. Pubmed and Scopus were used in order to identify research articles published between 2005 and 2012 in English language. A search term combination that included stomatitis, mucositis, lasers, complimentary therapies, amino acids, antioxidants, vitamins, minerals, plant extracts, and cryotherapy was conducted. A large number of therapeutic strategies to prevent and treat oral mucositis have been shown in studies and growth factors, including palifermin, appear as one of the most innovative drugs used in the management of oral mucositis. Understanding the physiopathological basis of mucositis can lead to the development of target drugs’ therapies. In addition, clinical trials should be conducted in order to determine an efficient protocol of treatment

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Oral cryotherapy can significantly reduce oral mucositis but not acute GVHD incidence in Flu/Mel conditioning allo-SCT

Cited by 8 publications

References 10 publications

Oral Complications in Hematopoietic Stem Cell Recipients: The Role of Inflammation

Oral Complications in Hematopoietic Stem Cell Recipients: The Role of Inflammation

Efficacy of cryotherapy associated with laser therapy for decreasing severity of melphalan‐induced oral mucositis during hematological stem‐cell transplantation: a prospective clinical study

Management of oral mucositis

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