Oral dispersible system: A new approach in drug delivery system

Hannan, PA; Ja, Khan; Khan, Aisha; S, Safiullah

doi:10.4103/0250-474x.180244

Cited by 75 publications

(62 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…48 and 0.55 g/cm 3 ), DT (between 0.55 and 0.65 g/cm 3 ), and Carr's compressibility index (between 12 and 26) given in (Table 2). The results of angle of repose and compressibility indicated that the flowability of powder blend is significantly good.…”

Section: Resultsmentioning

confidence: 99%

“…Oral route is undoubtedly the most important drug delivery route which offers various advantages like convenience of self-administration and easy manufacturing along with saving costs. [1][2][3] However many patients, especially geriatrics have dysphagia or difficulty in swallowing tablets and hard gelatin capsules and skip their prescribed medication, thus resulting in improper treatment. In these cases, orally disintegrating tablets (ODTs) have been found to be greatly useful.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Untitled

Wajid

2017

AJP

View full text Add to dashboard Cite

Objective: The objective of the study was to formulate and evaluate orally disintegrating tablet of orlistat. Materials and Methods: Direct compression method was used to formulate orally disintegrating tablet of orlistat by employing different superdisintegrants, entragit, and magnesium stearate (lubricant), Talc. These prepared formulations were then evaluated using pharmacopeia and non-pharmacopeia methods. Dissolution and assay tests were performed using USP apparatus II and ultraviolet spectrophotometry, respectively. Results: All formulations showed compliance with pharmacopeial standards. The effect of superdisintegrants concentration and direct compression method on drug release profile was studied. Release profile of F12 which contains 2% of Ac-di-sol in combination with entragit, were found to be satisfactory comparing to other formulations. Conclusion: Formulation prepared with Ac-di-sol in combination with entragit (F12), as processed excipient was found to be the best superdisintegrants for the preparation of orlistat orally disintegrating tablets formulations. Due to it has exhibited faster disintegration time and best dissolution profile when compared to other formulations.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Untitled

Wajid

2017

AJP

View full text Add to dashboard Cite

show abstract

“…SD refers to the group of solid products consisting of at least two different components, generally a hydrophilic matrix and a hydrophobic drug; the matrix can be either crystalline or amorphous [1]. The solid dispersion was introduced to overcome the low bioavailability of lipophilic drugs by forming a eutectic mixture of drugs with water soluble carriers.…”

Section: Solid Dispersionsmentioning

confidence: 99%

“…Fast dissolving tablets are also applicable when local action in the mouth is desirable such as local anesthetic for toothaches, oral ulcers, cold sores, or teething, and to those who cannot swallow intact sustained action tablets/capsules. The rate of absorption and the extent of bioavailability for such insoluble hydrophobic drug are controlled by the rate of dissolution [1]. Hence, an attempt has been made to increase the dissolution of such poorly water soluble drugs.…”

Section: Introductionmentioning

confidence: 99%

Fast Dissolving Tablet Using Solid Dispersion Technique: A Review

Das

Verma

Saha

2017

Int J Curr Pharm Sci

View full text Add to dashboard Cite

Fast dissolving tablets are also called as mouth-dissolving tablets, melt-in mouth tablets, orodispersible tablets, quick dissolving etc. Fast dissolving tablets are those when put on tongue disintegrate instantaneously releasing the drug, which dissolve or disperses in the saliva. The faster the drug dissolved into solution, quicker the absorption and onset of clinical effect. Oral routes of drug administration have wide acceptance up to 50-60% of total dosage forms. Fast dissolving tablet containing solid dispersion was developed to improve the dissolution of drug and stability of solid dispersion. They are disintegrating and/or dissolve rapidly in the saliva without the need for water. Thus it is regarded as the safest, most convenient and most economical method of drug delivery having the highest patient compliance. The later part of the article focus on the progress in methods of manufacturing, evaluation and various latest technologies involved in the development of Fast dissolving tablets. Solid dispersion is basically a drug-polymer two-component system; the drug-polymer interaction is the determining factor in its design and performance. It also discusses about modern characterization technique to characterize solid dispersion. In this review, it is intended to discuss the recent advances related on the area of solid dispersion technology. Different methods are also been used for preparation of solid dispersions such as Melting method, Solvent method, Melting solvent method, Melt extrusion method, lyophilisation Technique, Melt Agglomeration Process, The Use Of Surfactant, Electro spinning and Super Critical Fluid Technology. The introduction of fast dissolving dosage forms has solved some of the problems encountered in administration of drugs to the pediatric and elderly patient, which constitutes a large proportion of the world's population. Solid dispersions have attracted considerable interest as an efficient means of improving the dissolution rate and hence the bio availability of a range of poorly watersoluble drugs. The focus of one part of the review article is based on solid dispersion mainly advantages, disadvantages, types, the method of preparation, and characterization of the solid dispersion at laboratory and industrial level.

show abstract

“…The fast-dissolving tablets (FDTs) disintegrate and dissolve within seconds and are meant for administration to the patients who cannot swallow, such as elderly patients, stroke victims, bedridden patients, patients affected by renal failure, and patients who refuse to swallow, such as pediatric, geriatric, and psychiatric patients [3]. Hence, the present study was aimed at preparation of fast dissolving tablets of Pitavastatin using super disintegrant (Indion414) [4] and sublimating agent (camphor) [5] by direct compression method following 3 2 factorial design for the best-optimized formulation to increase dissolution of the drug, further to enhance absorption and bioavailability of drug for treating emergency clinical conditions of cardiovascular diseases.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Evaluation of Fast Dissolving Tablets of Pitavastatin by 32 Full Factorial Design

Nirmala¹,

Maruvajala²

2019

Int J App Pharm

View full text Add to dashboard Cite

Objective:The objective of the present work was to prepare an optimized, fast dissolving tablet (FDT) of Pitavastatin to increase its dissolution by applying 3 2 full factorial design.Methods: Nine formulations (PF1 to PF9) with all possible combinations according to 3 2 full factorial design by selecting two factors i.e. concentration of super disintegrant, Indion414 (5-15%) (A) and sublimating agent, camphor (40-60%) (B) as independent variables at three levels of-1, 0 and 1. The effect of these two variables on three dependent parameters, water absorption ratio (Y1), disintegration time (Y2) and in vitro drug release (Y3) was studied. All the powder blends were evaluated for precompression parameters, and the tablets were prepared by direct compression method which were further evaluated for post-compression parameters. The effect of change in concentration of two selected factors on dependent parameters was studied through 3D surface response plots and polynomial equations using Design expert software version11. Optimized formula was obtained by desirability and overlay plots for which compatibility stability was assessed.Results: Precompression and post-compression parameters were satisfactorily within acceptable limits. Optimized formulation was prepared to prove the validity of the evolved mathematical model, which contained 6.75 mg of indion414(0.9) and 54 mg of camphor(0.9) with a disintegration time of 21 sec., water absorption ratio of 113 and 93% of drug release within 12 min. The compatibility between drugs and excipients was proved. The dissolution profiles of optimized formulation and commercially available conventional film-coated tablets of Pitavastatin were compared. Conclusion:The optimized formulation showed significantly (P>0.05) increased drug release compared to commercially available film-coated tablets. No changes in disintegration time, drug content and in in vitro drug release from optimized formulation on storage for 3months at 40 °C±2 °C/75% RH±5% RH were observed during stability studies which confirmed the stability of the optimized formulation.

show abstract

Oral dispersible system: A new approach in drug delivery system

Cited by 75 publications

References 16 publications

Untitled

Untitled

Fast Dissolving Tablet Using Solid Dispersion Technique: A Review

Preparation and Evaluation of Fast Dissolving Tablets of Pitavastatin by 32 Full Factorial Design

Contact Info

Product

Resources

About